SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zei'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		3 / 3 MET A  98
ASN A  74
GLN A 144
 None
PLP  A1301 (-3.8A)
AWH  A1302 (-3.3A)
 0.90A 1xoqB-3zeiA:
undetectable		 1xoqB-3zeiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		5 / 11 GLU A 203
ALA A 201
PRO A 204
ALA A 273
ASP A 238
 None
 1.31A 2admA-3zeiA:
2.6		 2admA-3zeiA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		5 / 11 GLU A 203
ALA A 201
PRO A 204
ALA A 273
ASP A 238
 None
 1.32A 2admB-3zeiA:
2.6		 2admB-3zeiA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
None
PLP  A1301 (-3.8A)
None
None
 1.16A 2dcfA-3zeiA:
undetectable		 2dcfA-3zeiA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 270
VAL A 291
GLN A 144
THR A 179
ASP A 294
 None
None
AWH  A1302 (-3.3A)
PLP  A1301 (-2.8A)
PLP  A1301 (-3.3A)
 1.21A 2v95A-3zeiA:
undetectable		 2v95A-3zeiA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
None
PLP  A1301 (-3.8A)
None
None
 1.13A 2zmaA-3zeiA:
undetectable		 2zmaA-3zeiA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
None
PLP  A1301 (-3.8A)
None
None
 1.18A 3a65A-3zeiA:
undetectable		 3a65A-3zeiA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A66_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
None
PLP  A1301 (-3.8A)
None
None
 1.16A 3a66A-3zeiA:
0.0		 3a66A-3zeiA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
None
PLP  A1301 (-3.8A)
None
None
 1.15A 3vwpA-3zeiA:
0.0		 3vwpA-3zeiA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
None
PLP  A1301 (-3.8A)
None
None
 1.16A 3vwqA-3zeiA:
undetectable		 3vwqA-3zeiA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
None
PLP  A1301 (-3.8A)
None
None
 1.15A 3vwrA-3zeiA:
undetectable		 3vwrA-3zeiA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 153
ASN A 147
LEU A  52
ILE A  67
 None
 0.65A 4r38A-3zeiA:
undetectable		 4r38A-3zeiA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 180
GLY A 226
GLY A 224
GLY A 178
GLU A 203
 PLP  A1301 (-3.3A)
None
None
PLP  A1301 (-3.6A)
None
 0.96A 5njvC-3zeiA:
undetectable		 5njvC-3zeiA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A  14
GLU A 161
HIS A 154
 None
 0.89A 5xioA-3zeiA:
undetectable		 5xioA-3zeiA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A  14
GLU A 161
HIS A 154
 None
 0.90A 5xiqB-3zeiA:
undetectable		 5xiqB-3zeiA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A  14
GLU A 161
HIS A 154
 None
 0.90A 5xiqD-3zeiA:
undetectable		 5xiqD-3zeiA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3zei O-ACETYLSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		6 / 12 PRO A 204
GLY A 178
GLY A 222
ILE A 240
VAL A 243
GLY A 176
 None
PLP  A1301 (-3.6A)
PLP  A1301 ( 3.5A)
None
None
None
 1.47A 5zhmB-3zeiA:
undetectable		 5zhmB-3zeiA:
23.40