SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zf8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 134
LEU A 137
THR A 242
PHE A 126
ILE A 240
 None
 1.10A 1i18A-3zf8A:
undetectable
1i18B-3zf8A:
undetectable		 1i18A-3zf8A:
16.06
1i18B-3zf8A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 126
ILE A 240
LEU A 134
LEU A 137
THR A 242
 None
 1.12A 1i18A-3zf8A:
undetectable
1i18B-3zf8A:
undetectable		 1i18A-3zf8A:
16.06
1i18B-3zf8A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 256
PHE A 380
GLU A 330
LEU A 382
ALA A 259
 None
 1.31A 1mjlA-3zf8A:
undetectable
1mjlB-3zf8A:
undetectable		 1mjlA-3zf8A:
15.59
1mjlB-3zf8A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		4 / 7 THR A 121
PHE A 148
PHE A 126
LEU A 137
 None
 1.11A 1qcaA-3zf8A:
undetectable		 1qcaA-3zf8A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 339
GLY A 337
LEU A 333
GLY A 335
LYS A 344
 None
 1.20A 1y4lA-3zf8A:
undetectable		 1y4lA-3zf8A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 157
LEU A 160
LYS A 161
ARG A 186
 None
 1.26A 2gj5A-3zf8A:
undetectable		 2gj5A-3zf8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 143
ALA A 110
SER A 230
THR A 107
 None
 1.06A 3cfqA-3zf8A:
undetectable		 3cfqA-3zf8A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 257
VAL A 343
ILE A 247
LEU A 382
VAL A 336
 None
 1.23A 3fpjB-3zf8A:
undetectable		 3fpjB-3zf8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 337
GLY A 338
ASN A 236
GLU A 366
 None
None
GDP  A1395 (-3.5A)
None
 1.23A 4fglC-3zf8A:
undetectable		 4fglC-3zf8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 380
LEU A 382
ASN A 384
PRO A 383
 None
 1.43A 4yv5B-3zf8A:
undetectable		 4yv5B-3zf8A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 380
LEU A 382
ASN A 384
PRO A 383
 None
 1.45A 4yv5A-3zf8A:
undetectable		 4yv5A-3zf8A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_B_FOLB201_0
(FOLATE ECF
TRANSPORTER)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 166
PHE A 148
THR A 150
ASN A 236
THR A 121
 None
None
None
GDP  A1395 (-3.5A)
None
 1.31A 4z7fB-3zf8A:
0.9		 4z7fB-3zf8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_E_FOLE201_0
(FOLATE ECF
TRANSPORTER)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 166
PHE A 148
THR A 150
ASN A 236
THR A 121
 None
None
None
GDP  A1395 (-3.5A)
None
 1.39A 4z7fE-3zf8A:
1.0		 4z7fE-3zf8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 364
VAL A 379
LEU A 333
GLY A 337
ARG A 209
 None
None
None
None
GDP  A1395 (-3.6A)
 1.20A 5vooE-3zf8A:
undetectable		 5vooE-3zf8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 364
VAL A 379
LEU A 333
GLY A 337
ARG A 209
 None
None
None
None
GDP  A1395 (-3.6A)
 1.18A 5vopB-3zf8A:
undetectable		 5vopB-3zf8A:
22.12