SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zfc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		5 / 12 ASP A 281
ALA A 331
GLY A 303
LEU A 309
TYR A 289
 None
 0.88A 1kiaC-3zfcA:
undetectable		 1kiaC-3zfcA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		5 / 12 VAL A 201
LEU A 151
GLY A 100
ALA A 101
THR A 103
 None
 0.91A 1r9oA-3zfcA:
undetectable		 1r9oA-3zfcA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		6 / 12 LEU A 309
LEU A  72
ALA A  70
LEU A 121
LEU A 239
ILE A 311
 None
 1.30A 1s9pA-3zfcA:
undetectable		 1s9pA-3zfcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		4 / 7 TYR A 289
THR A  83
THR A 308
VAL A 274
 None
 1.15A 1tv8A-3zfcA:
undetectable		 1tv8A-3zfcA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		4 / 8 TYR A 289
THR A  83
THR A 308
VAL A 274
 None
 1.16A 2fb2A-3zfcA:
undetectable		 2fb2A-3zfcA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		4 / 7 TYR A 289
THR A  83
THR A 308
VAL A 274
 None
 1.17A 2fb2B-3zfcA:
undetectable		 2fb2B-3zfcA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		5 / 12 PHE A  65
VAL A 114
PHE A 134
ILE A 221
ILE A 219
 None
 1.10A 2ft9A-3zfcA:
undetectable		 2ft9A-3zfcA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		5 / 12 LEU A 309
ASP A 241
ILE A 115
GLY A 113
VAL A  84
 None
MG  A 500 ( 4.1A)
None
None
None
 0.83A 2nnkB-3zfcA:
undetectable		 2nnkB-3zfcA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		5 / 12 ALA A  68
ILE A 311
PHE A  65
LEU A 239
ILE A  73
 None
 1.13A 2w3vA-3zfcA:
undetectable		 2w3vA-3zfcA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		4 / 6 LYS A 252
GLN A 248
GLY A 261
ARG A 259
 None
 1.07A 3bjwE-3zfcA:
undetectable		 3bjwE-3zfcA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		5 / 12 ALA A 331
LEU A  14
GLU A 323
PRO A 316
LEU A 321
 None
 1.37A 3eigA-3zfcA:
undetectable		 3eigA-3zfcA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		5 / 7 GLU A  62
GLU A  63
ARG A  15
GLY A 113
ARG A 117
 None
None
ANP  A 501 ( 3.8A)
None
None
 1.38A 4fgzA-3zfcA:
undetectable		 4fgzA-3zfcA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		4 / 8 GLU A  62
GLU A  63
GLY A 113
ARG A 117
 None
 1.04A 4fgzA-3zfcA:
undetectable
4fgzB-3zfcA:
undetectable		 4fgzA-3zfcA:
20.63
4fgzB-3zfcA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		4 / 7 PRO A 316
LEU A  14
TYR A  51
LEU A 328
 None
 1.07A 4iomA-3zfcA:
undetectable		 4iomA-3zfcA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		5 / 12 CYH A 191
LEU A 192
LEU A 152
VAL A 182
ILE A 219
 None
 0.93A 4x1yD-3zfcA:
undetectable		 4x1yD-3zfcA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		5 / 12 ILE A 216
ALA A 215
ARG A 199
ALA A  86
LEU A 242
 None
 1.27A 4zo1X-3zfcA:
undetectable		 4zo1X-3zfcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		4 / 5 ILE A 112
ILE A 119
TYR A 102
GLU A 193
 None
 1.17A 4zzcE-3zfcA:
undetectable		 4zzcE-3zfcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		4 / 5 ILE A 262
ILE A 264
ARG A 212
GLU A 260
 None
 1.14A 4zzcE-3zfcA:
undetectable		 4zzcE-3zfcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		4 / 5 SER A  97
GLY A 244
THR A 251
GLU A 246
 None
ANP  A 501 (-3.5A)
None
None
 1.20A 5btiA-3zfcA:
undetectable
5btiB-3zfcA:
undetectable		 5btiA-3zfcA:
21.49
5btiB-3zfcA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		4 / 5 SER A  97
GLY A 244
THR A 251
GLU A 246
 None
ANP  A 501 (-3.5A)
None
None
 1.20A 5btiC-3zfcA:
undetectable
5btiD-3zfcA:
undetectable		 5btiC-3zfcA:
21.49
5btiD-3zfcA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		5 / 12 ILE A 275
VAL A  12
LEU A 271
LEU A  85
LEU A 242
 None
 1.31A 5tiwA-3zfcA:
undetectable		 5tiwA-3zfcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		3 / 3 GLU A 254
LEU A 258
ARG A 259
 None
 0.24A 6d8fA-3zfcA:
undetectable		 6d8fA-3zfcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4
(Mus
musculus) 		4 / 6 GLY A 261
ARG A 199
SER A 211
SER A 210
 None
None
MG  A 500 ( 2.1A)
ANP  A 501 (-2.6A)
 1.09A 6jogA-3zfcA:
undetectable		 6jogA-3zfcA:
20.90