SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zfv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		4 / 7 LEU A 258
ALA A 259
TYR A 262
GLU A 127
 None
 0.75A 1dmaA-3zfvA:
undetectable		 1dmaA-3zfvA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		5 / 9 ILE A 244
VAL A 177
GLY A 174
ALA A 253
LEU A 257
 None
 1.15A 1e7bA-3zfvA:
undetectable		 1e7bA-3zfvA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		3 / 3 LEU A  19
PRO A  20
ARG A  64
 None
 0.52A 2qd4B-3zfvA:
undetectable		 2qd4B-3zfvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		3 / 3 LEU A  19
PRO A  20
ARG A  64
 None
 0.51A 2qd5A-3zfvA:
undetectable		 2qd5A-3zfvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		5 / 12 VAL A 128
SER A 204
SER A 208
ALA A 253
ARG A 255
 None
 1.45A 2qm9B-3zfvA:
undetectable		 2qm9B-3zfvA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		5 / 11 LEU A 263
GLY A 264
ILE A 276
LYS A 277
THR A  84
 None
 1.15A 3bjwB-3zfvA:
undetectable		 3bjwB-3zfvA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		5 / 12 LEU A 263
GLY A 264
ILE A 276
LYS A 277
THR A  84
 None
 1.20A 3bjwF-3zfvA:
undetectable		 3bjwF-3zfvA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		5 / 11 LEU A 263
GLY A 264
ILE A 276
LYS A 277
THR A  84
 None
 1.14A 3bjwH-3zfvA:
undetectable		 3bjwH-3zfvA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		3 / 3 LYS A  73
ILE A 141
PHE A 140
 None
 0.86A 3j7zS-3zfvA:
undetectable
3j7za-3zfvA:
undetectable		 3j7zS-3zfvA:
15.92
3j7za-3zfvA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		4 / 5 PHE A 273
ILE A 222
GLY A 270
HIS A  57
 None
 1.17A 3r0lD-3zfvA:
undetectable		 3r0lD-3zfvA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		5 / 12 ARG A 255
ILE A 244
GLY A 174
ALA A 178
ALA A 253
 None
 0.98A 3sudC-3zfvA:
undetectable		 3sudC-3zfvA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		5 / 12 ILE A 244
VAL A 177
LEU A 146
SER A 168
LEU A 215
 None
 1.16A 3w67C-3zfvA:
undetectable		 3w67C-3zfvA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		4 / 6 GLU A 275
ILE A 276
GLU A 127
VAL A 119
 None
 0.95A 4ejwB-3zfvA:
undetectable		 4ejwB-3zfvA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		4 / 5 VAL A 121
LEU A 187
ILE A   4
LEU A   3
 None
 0.83A 4mghA-3zfvA:
undetectable		 4mghA-3zfvA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		4 / 8 SER A 115
THR A  84
SER A  82
TYR A 262
 None
 1.30A 4qb9D-3zfvA:
undetectable		 4qb9D-3zfvA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		4 / 5 ASP A 246
LYS A 248
ARG A 252
ILE A 244
 None
 1.42A 5a06B-3zfvA:
undetectable		 5a06B-3zfvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		4 / 5 ASP A 246
LYS A 248
ARG A 252
ILE A 244
 None
 1.43A 5a06D-3zfvA:
undetectable		 5a06D-3zfvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSH_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		4 / 5 ARG A 269
LEU A 263
ASN A 186
VAL A 183
 None
 1.49A 5cshB-3zfvA:
undetectable		 5cshB-3zfvA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		4 / 5 ARG A 269
LEU A 263
ASN A 186
VAL A 183
 None
 1.49A 5os7B-3zfvA:
undetectable		 5os7B-3zfvA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1
(Sulfolobus
solfataricus) 		4 / 5 ARG A 269
LEU A 263
ASN A 186
VAL A 183
 None
 1.49A 6gmdA-3zfvA:
undetectable		 6gmdA-3zfvA:
21.77