SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zfx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.84A 1iepB-3zfxA:
31.6		 1iepB-3zfxA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 ALA A 649
LYS A 651
GLU A 668
THR A 697
MET A 700
GLY A 703
LEU A 751
ASP A 762
 None
 0.72A 1m17A-3zfxA:
34.5		 1m17A-3zfxA:
36.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.75A 1opjA-3zfxA:
31.5		 1opjA-3zfxA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.81A 1opjB-3zfxA:
31.7		 1opjB-3zfxA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 649
LYS A 651
GLU A 668
THR A 697
LEU A 735
HIS A 742
 None
 0.81A 1uwhB-3zfxA:
28.9		 1uwhB-3zfxA:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
GLU A 668
THR A 697
LEU A 735
HIS A 742
 None
 0.75A 1uwjA-3zfxA:
7.6		 1uwjA-3zfxA:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ILE A 625
VAL A 633
ALA A 649
GLU A 668
THR A 697
LEU A 735
HIS A 742
 None
 0.96A 1uwjB-3zfxA:
7.6		 1uwjB-3zfxA:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 649
THR A 697
GLY A 703
LEU A 751
ASP A 762
PHE A 763
 None
 0.91A 1xkkA-3zfxA:
31.6		 1xkkA-3zfxA:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 ALA A 649
GLU A 668
MET A 672
ILE A 695
THR A 697
PHE A 699
GLY A 703
LEU A 751
 None
 0.61A 2gqgA-3zfxA:
34.7		 2gqgA-3zfxA:
41.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 649
LYS A 651
GLU A 668
MET A 672
ILE A 695
PHE A 699
GLY A 703
 None
 0.78A 2gqgA-3zfxA:
34.7		 2gqgA-3zfxA:
41.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
ILE A 695
THR A 697
GLY A 703
LEU A 751
 None
 0.74A 2gqgB-3zfxA:
34.5		 2gqgB-3zfxA:
41.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.79A 2hyyA-3zfxA:
32.2		 2hyyA-3zfxA:
41.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.80A 2hyyB-3zfxA:
32.1		 2hyyB-3zfxA:
41.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
THR A 697
PHE A 699
GLY A 703
LEU A 751
 None
 0.76A 2hyyB-3zfxA:
32.1		 2hyyB-3zfxA:
41.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
ILE A 695
THR A 697
PHE A 699
 None
 0.77A 2hyyD-3zfxA:
31.9		 2hyyD-3zfxA:
41.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 633
ALA A 649
MET A 672
ILE A 695
THR A 697
PHE A 699
LEU A 751
 None
 1.00A 2hyyD-3zfxA:
31.9		 2hyyD-3zfxA:
41.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 649
LYS A 651
GLU A 668
MET A 672
THR A 697
GLY A 703
LEU A 751
 None
 0.80A 2itoA-3zfxA:
34.7		 2itoA-3zfxA:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		9 / 12 GLY A 626
VAL A 633
ALA A 649
LYS A 651
GLU A 668
MET A 672
GLY A 703
LEU A 751
ASP A 762
 None
 0.74A 2ityA-3zfxA:
34.5		 2ityA-3zfxA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 GLY A 626
VAL A 633
ALA A 649
MET A 672
THR A 697
GLY A 703
LEU A 751
ASP A 762
 None
 0.58A 2ityA-3zfxA:
34.5		 2ityA-3zfxA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
THR A 697
GLY A 703
LEU A 751
ASP A 762
 None
 0.75A 2itzA-3zfxA:
34.3		 2itzA-3zfxA:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
LYS A 651
GLU A 668
MET A 672
GLY A 703
LEU A 751
ASP A 762
 None
 0.69A 2itzA-3zfxA:
34.3		 2itzA-3zfxA:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 GLY A 626
VAL A 633
ALA A 649
MET A 700
GLY A 703
ASP A 762
 None
 0.76A 2wgjA-3zfxA:
31.6		 2wgjA-3zfxA:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 9 VAL A 633
ALA A 649
MET A 700
GLY A 703
LEU A 751
ASP A 762
 None
 0.39A 2xp2A-3zfxA:
34.8		 2xp2A-3zfxA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		9 / 12 ILE A 625
ALA A 649
GLU A 668
MET A 672
ILE A 695
THR A 697
GLY A 703
LEU A 751
SER A 761
 None
 0.77A 2y6oA-3zfxA:
38.6		 2y6oA-3zfxA:
80.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		9 / 12 ILE A 625
ALA A 649
LYS A 651
GLU A 668
MET A 672
ILE A 695
THR A 697
GLY A 703
LEU A 751
 None
 0.79A 2y6oA-3zfxA:
38.6		 2y6oA-3zfxA:
80.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 ILE A 625
VAL A 633
ALA A 649
ILE A 681
MET A 700
GLY A 703
LEU A 751
ASP A 762
 None
 0.70A 2y7jA-3zfxA:
26.1		 2y7jA-3zfxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 10 ILE A 625
VAL A 633
ALA A 649
ILE A 681
MET A 700
GLY A 703
LEU A 751
ASP A 762
 None
 0.60A 2y7jB-3zfxA:
26.8		 2y7jB-3zfxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 10 ILE A 625
VAL A 633
ALA A 649
ILE A 681
MET A 700
GLY A 703
LEU A 751
 None
 0.48A 2y7jC-3zfxA:
26.2		 2y7jC-3zfxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 10 ILE A 625
VAL A 633
ALA A 649
ILE A 681
MET A 700
GLY A 703
LEU A 751
 None
 0.37A 2y7jD-3zfxA:
26.6		 2y7jD-3zfxA:
22.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		9 / 12 ALA A 649
LYS A 651
GLU A 668
MET A 672
ILE A 695
THR A 697
MET A 700
GLY A 703
LEU A 751
 None
 0.55A 2zvaA-3zfxA:
35.5		 2zvaA-3zfxA:
39.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
LEU A 683
THR A 697
GLY A 703
LEU A 751
 None
 0.65A 3bbtB-3zfxA:
31.1		 3bbtB-3zfxA:
35.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 649
THR A 697
GLY A 703
HIS A 742
LEU A 751
 None
 0.44A 3cs9A-3zfxA:
32.1		 3cs9A-3zfxA:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.71A 3cs9C-3zfxA:
31.7		 3cs9C-3zfxA:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.62A 3cs9D-3zfxA:
31.4		 3cs9D-3zfxA:
41.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 649
THR A 697
PHE A 699
GLY A 703
HIS A 742
 None
 0.53A 3cs9D-3zfxA:
31.4		 3cs9D-3zfxA:
41.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 11 ALA A 704
LEU A 751
ALA A 649
VAL A 633
LYS A 635
 None
 1.20A 3e22B-3zfxA:
undetectable		 3e22B-3zfxA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 11 ALA A 704
LEU A 751
ALA A 649
VAL A 633
LYS A 635
 None
 1.20A 3e22D-3zfxA:
undetectable		 3e22D-3zfxA:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
ILE A 695
THR A 697
GLY A 703
LEU A 751
 None
 0.72A 3g5dA-3zfxA:
34.8		 3g5dA-3zfxA:
42.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
LYS A 651
GLU A 668
MET A 672
THR A 697
GLY A 703
LEU A 751
 None
 0.76A 3g5dB-3zfxA:
34.7		 3g5dB-3zfxA:
42.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
LYS A 651
GLU A 668
ILE A 681
THR A 697
 None
 0.84A 3hegA-3zfxA:
21.0		 3hegA-3zfxA:
24.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 ALA A 649
LYS A 651
GLU A 668
MET A 672
ILE A 695
THR A 697
GLY A 703
LEU A 751
 None
 0.65A 3k54A-3zfxA:
32.4		 3k54A-3zfxA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 ALA A 649
LYS A 651
MET A 672
ILE A 695
THR A 697
GLY A 703
LEU A 751
SER A 761
 None
 0.77A 3k54A-3zfxA:
32.4		 3k54A-3zfxA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.76A 3k5vA-3zfxA:
31.7		 3k5vA-3zfxA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.79A 3k5vB-3zfxA:
31.6		 3k5vB-3zfxA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
THR A 697
PHE A 699
GLY A 703
LEU A 751
 None
 0.75A 3k5vB-3zfxA:
31.6		 3k5vB-3zfxA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		9 / 11 ILE A 625
ALA A 649
LYS A 651
PHE A 699
MET A 700
GLY A 703
LEU A 751
SER A 761
ASP A 762
 None
 0.59A 3miyA-3zfxA:
34.8		 3miyA-3zfxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 9 ILE A 625
ALA A 649
LYS A 651
PHE A 699
MET A 700
GLY A 703
LEU A 751
SER A 761
 None
 0.39A 3miyB-3zfxA:
34.6		 3miyB-3zfxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.80A 3ms9A-3zfxA:
31.3		 3ms9A-3zfxA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.78A 3mssA-3zfxA:
31.5		 3mssA-3zfxA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.80A 3mssC-3zfxA:
31.5		 3mssC-3zfxA:
40.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		3 / 3 ARG A 823
ILE A 812
TRP A 790
 None
 1.09A 3nw2A-3zfxA:
undetectable		 3nw2A-3zfxA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ILE A 625
VAL A 633
ALA A 649
LYS A 651
THR A 697
PHE A 763
 None
 0.97A 3og7A-3zfxA:
28.3		 3og7A-3zfxA:
32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 GLY A 626
VAL A 633
ALA A 649
LYS A 651
ILE A 681
THR A 697
LEU A 751
 None
 0.97A 3ohtA-3zfxA:
17.0		 3ohtA-3zfxA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 GLY A 626
VAL A 633
ALA A 649
ILE A 681
THR A 697
GLY A 703
 None
 0.84A 3ohtB-3zfxA:
16.9		 3ohtB-3zfxA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 GLY A 626
VAL A 633
ALA A 649
ILE A 681
THR A 697
LEU A 751
 None
 0.95A 3ohtB-3zfxA:
16.9		 3ohtB-3zfxA:
27.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.67A 3pyyA-3zfxA:
32.0		 3pyyA-3zfxA:
40.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
THR A 697
GLY A 703
LEU A 751
ASP A 762
 None
 0.84A 3qlgB-3zfxA:
34.4		 3qlgB-3zfxA:
42.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 633
ALA A 649
MET A 672
ILE A 695
THR A 697
GLY A 703
LEU A 751
 None
 0.53A 3sxrA-3zfxA:
33.0		 3sxrA-3zfxA:
38.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 ALA A 649
LYS A 651
ILE A 695
THR A 697
PHE A 699
MET A 700
GLY A 703
LEU A 751
 None
 0.68A 3ue4A-3zfxA:
34.3		 3ue4A-3zfxA:
40.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
MET A 672
ILE A 695
THR A 697
PHE A 699
GLY A 703
LEU A 751
 None
 0.76A 3ue4B-3zfxA:
34.4		 3ue4B-3zfxA:
40.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 649
MET A 700
GLY A 703
LEU A 751
ASP A 762
 None
 0.39A 3zbfA-3zfxA:
35.6		 3zbfA-3zfxA:
36.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 649
LYS A 651
THR A 697
LEU A 735
HIS A 742
ARG A 743
LEU A 751
 None
 0.84A 3zosA-3zfxA:
30.5		 3zosA-3zfxA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 9 ILE A 671
MET A 672
ILE A 680
ILE A 681
MET A 700
 None
 0.66A 3zosA-3zfxA:
30.5		 3zosA-3zfxA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 ALA A 649
LYS A 651
GLU A 668
ILE A 681
THR A 697
LEU A 735
HIS A 742
ARG A 743
 None
 0.92A 3zosB-3zfxA:
30.5		 3zosB-3zfxA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 ALA A 649
LYS A 651
ILE A 681
THR A 697
LEU A 735
HIS A 742
ARG A 743
LEU A 751
 None
 0.84A 3zosB-3zfxA:
30.5		 3zosB-3zfxA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 9 VAL A 633
ALA A 649
MET A 700
GLY A 703
LEU A 751
ASP A 762
 None
 0.40A 4anqA-3zfxA:
34.4		 4anqA-3zfxA:
35.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 9 VAL A 633
ALA A 649
MET A 700
GLY A 703
LEU A 751
ASP A 762
 None
 0.44A 4ansA-3zfxA:
34.3		 4ansA-3zfxA:
35.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
LYS A 651
GLU A 668
PHE A 699
GLY A 703
LEU A 735
HIS A 742
 None
 0.98A 4asdA-3zfxA:
31.9		 4asdA-3zfxA:
30.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
GLU A 668
ILE A 671
ILE A 681
THR A 697
 None
 0.83A 4bkjA-3zfxA:
30.5		 4bkjA-3zfxA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
ILE A 681
THR A 697
 None
 0.89A 4bkjA-3zfxA:
30.5		 4bkjA-3zfxA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 633
ALA A 649
GLU A 668
ILE A 671
MET A 672
ILE A 681
THR A 697
 None
 0.95A 4bkjB-3zfxA:
30.6		 4bkjB-3zfxA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 633
ALA A 649
ILE A 671
MET A 672
ILE A 681
THR A 697
LEU A 751
 None
 1.16A 4bkjB-3zfxA:
30.6		 4bkjB-3zfxA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 649
LYS A 651
THR A 697
MET A 700
GLY A 703
LEU A 751
ASP A 762
 None
 0.87A 4hjoA-3zfxA:
32.0		 4hjoA-3zfxA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 633
ALA A 649
LYS A 651
THR A 697
MET A 700
GLY A 703
LEU A 751
 None
 0.73A 4hjoA-3zfxA:
32.0		 4hjoA-3zfxA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 10 ILE A 625
ALA A 649
PHE A 699
GLY A 703
LEU A 751
SER A 761
ASP A 762
 None
 0.56A 4ks8A-3zfxA:
26.3		 4ks8A-3zfxA:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_2
(SERUM ALBUMIN)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		4 / 4 VAL A 686
GLU A 668
ASP A 676
LYS A 759
 None
 1.48A 4l9qA-3zfxA:
1.2		 4l9qA-3zfxA:
17.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 633
ALA A 649
LYS A 651
GLY A 703
SER A 707
LEU A 751
ASP A 762
 None
 0.54A 4mkcA-3zfxA:
34.1		 4mkcA-3zfxA:
31.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
ILE A 695
THR A 697
GLY A 703
ASP A 762
 None
 0.58A 4mxoA-3zfxA:
35.4		 4mxoA-3zfxA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
LYS A 651
GLU A 668
MET A 672
ILE A 695
GLY A 703
ASP A 762
 None
 0.79A 4mxoA-3zfxA:
35.4		 4mxoA-3zfxA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
GLU A 668
ILE A 695
THR A 697
GLY A 703
LEU A 751
ASP A 762
 None
 0.62A 4mxoB-3zfxA:
35.4		 4mxoB-3zfxA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 ALA A 649
LYS A 651
GLU A 668
MET A 672
ILE A 695
THR A 697
GLY A 703
LEU A 751
 None
 0.79A 4mxxA-3zfxA:
35.3		 4mxxA-3zfxA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 633
ALA A 649
LYS A 651
THR A 697
MET A 700
GLY A 703
LEU A 751
 None
 0.62A 4mxxB-3zfxA:
33.0		 4mxxB-3zfxA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
LYS A 651
GLU A 668
MET A 672
THR A 697
 None
 0.73A 4r7iA-3zfxA:
31.5		 4r7iA-3zfxA:
31.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 10 ILE A 625
ALA A 649
LYS A 651
ILE A 681
THR A 697
 None
 0.64A 4rz7A-3zfxA:
7.4		 4rz7A-3zfxA:
15.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
PHE A 699
MET A 700
GLY A 703
ASN A 749
LEU A 751
ASP A 762
 None
 0.63A 4twpA-3zfxA:
33.9		 4twpA-3zfxA:
40.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
PHE A 699
MET A 700
GLY A 703
ASN A 749
LEU A 751
ASP A 762
 None
 0.59A 4twpB-3zfxA:
34.4		 4twpB-3zfxA:
40.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 649
LYS A 651
THR A 697
GLY A 703
HIS A 742
LEU A 751
 None
 0.62A 4u0iA-3zfxA:
32.2		 4u0iA-3zfxA:
34.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 11 ALA A 649
THR A 697
MET A 700
GLY A 703
ASN A 749
LEU A 751
 None
 0.21A 4wa9A-3zfxA:
30.3		 4wa9A-3zfxA:
41.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
THR A 697
PHE A 699
MET A 700
GLY A 703
ASN A 749
LEU A 751
 None
 0.64A 4wa9B-3zfxA:
33.3		 4wa9B-3zfxA:
41.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		9 / 12 VAL A 633
ALA A 649
LYS A 651
MET A 672
ILE A 695
THR A 697
PHE A 699
GLY A 703
LEU A 751
 None
 0.91A 4xeyA-3zfxA:
34.4		 4xeyA-3zfxA:
31.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 633
ALA A 649
ILE A 695
THR A 697
PHE A 699
GLY A 703
LEU A 751
 None
 0.41A 4xeyB-3zfxA:
33.8		 4xeyB-3zfxA:
31.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 649
GLU A 668
MET A 672
ILE A 695
THR A 697
GLY A 703
LEU A 751
 None
 0.60A 4xliB-3zfxA:
35.1		 4xliB-3zfxA:
40.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
LYS A 651
THR A 697
ASP A 762
PHE A 763
 None
 0.88A 4xv2A-3zfxA:
28.2		 4xv2A-3zfxA:
32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 649
LYS A 651
THR A 697
ASP A 762
PHE A 763
 None
 0.70A 4xv2B-3zfxA:
28.4		 4xv2B-3zfxA:
32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 9 VAL A 633
ALA A 649
MET A 700
GLY A 703
LEU A 751
ASP A 762
 None
 0.37A 5aaaA-3zfxA:
34.5		 5aaaA-3zfxA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 10 VAL A 633
ALA A 649
LYS A 651
MET A 700
GLY A 703
LEU A 751
ASP A 762
 None
 0.78A 5aabA-3zfxA:
34.5		 5aabA-3zfxA:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 10 VAL A 633
ALA A 649
MET A 700
GLY A 703
LEU A 751
ASP A 762
 None
 0.41A 5aacA-3zfxA:
34.4		 5aacA-3zfxA:
35.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 GLY A 626
ALA A 649
PHE A 699
GLY A 703
LEU A 751
ASP A 762
 None
 0.79A 5ajqA-3zfxA:
24.7		 5ajqA-3zfxA:
28.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
ILE A 681
THR A 697
GLY A 703
LEU A 751
 None
 0.94A 5bvwA-3zfxA:
30.4		 5bvwA-3zfxA:
36.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 VAL A 633
ALA A 649
LYS A 651
THR A 697
PHE A 763
 None
 0.80A 5cswA-3zfxA:
28.0		 5cswA-3zfxA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 VAL A 633
ALA A 649
LYS A 651
THR A 697
PHE A 763
 None
 0.74A 5cswB-3zfxA:
27.9		 5cswB-3zfxA:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 VAL A 633
ALA A 649
THR A 697
GLY A 703
LEU A 751
 None
 0.40A 5h2uA-3zfxA:
30.8		 5h2uA-3zfxA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		3 / 3 ILE A 695
MET A 700
ASP A 762
 None
 0.77A 5h2uA-3zfxA:
30.9		 5h2uA-3zfxA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 633
ALA A 649
ILE A 695
THR A 697
GLY A 703
LEU A 751
ASP A 762
 None
 0.71A 5h2uB-3zfxA:
31.1		 5h2uB-3zfxA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 649
ILE A 695
THR A 697
GLY A 703
LEU A 751
 None
 0.57A 5h2uC-3zfxA:
30.9		 5h2uC-3zfxA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 649
LYS A 651
THR A 697
GLY A 703
LEU A 751
 None
 0.68A 5h2uC-3zfxA:
30.9		 5h2uC-3zfxA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
ILE A 695
GLY A 703
LEU A 751
ASP A 762
 None
 0.64A 5h2uD-3zfxA:
31.1		 5h2uD-3zfxA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
THR A 697
GLY A 703
LEU A 751
ASP A 762
 None
 0.63A 5h2uD-3zfxA:
31.1		 5h2uD-3zfxA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 VAL A 633
ALA A 649
ILE A 681
ILE A 695
THR A 697
 None
 0.44A 5hesA-3zfxA:
10.9		 5hesA-3zfxA:
31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 VAL A 633
ALA A 649
LYS A 651
ILE A 695
THR A 697
 None
 0.42A 5hesB-3zfxA:
27.7		 5hesB-3zfxA:
31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 VAL A 633
ALA A 649
LYS A 651
ILE A 695
THR A 697
 None
 0.59A 5hieA-3zfxA:
27.1		 5hieA-3zfxA:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 VAL A 633
ALA A 649
LYS A 651
ILE A 695
THR A 697
 None
 0.60A 5hieB-3zfxA:
27.2		 5hieB-3zfxA:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 VAL A 633
ALA A 649
LYS A 651
ILE A 695
THR A 697
 None
 0.59A 5hieD-3zfxA:
27.3		 5hieD-3zfxA:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ILE A 625
ALA A 649
GLU A 668
ILE A 681
GLY A 703
LEU A 751
SER A 761
 None
 0.73A 5i9xA-3zfxA:
37.9		 5i9xA-3zfxA:
69.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 ILE A 625
ALA A 649
GLU A 668
ILE A 681
ILE A 695
THR A 697
GLY A 703
LEU A 751
 None
 0.49A 5i9xA-3zfxA:
37.9		 5i9xA-3zfxA:
69.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		9 / 12 ILE A 625
ALA A 649
LYS A 651
GLU A 668
MET A 672
THR A 697
GLY A 703
LEU A 751
SER A 761
 None
 0.67A 5i9yA-3zfxA:
37.9		 5i9yA-3zfxA:
69.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		3 / 3 ILE A 681
ILE A 695
MET A 700
 None
 0.40A 5i9yA-3zfxA:
37.9		 5i9yA-3zfxA:
69.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 9 ILE A 625
GLY A 626
VAL A 633
ALA A 649
ILE A 681
LEU A 751
 None
 1.48A 5lw1B-3zfxA:
20.9		 5lw1B-3zfxA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 9 ILE A 625
GLY A 626
VAL A 633
ALA A 649
ILE A 681
MET A 700
 None
 0.74A 5lw1B-3zfxA:
20.9		 5lw1B-3zfxA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 10 GLY A 626
VAL A 633
ALA A 649
ILE A 681
MET A 700
 None
 0.82A 5lw1E-3zfxA:
20.6		 5lw1E-3zfxA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 GLU A 623
ILE A 625
GLY A 626
VAL A 633
ALA A 649
LYS A 651
GLU A 668
GLY A 703
 None
 0.83A 5mafA-3zfxA:
26.0		 5mafA-3zfxA:
11.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
LYS A 651
ILE A 695
THR A 697
GLY A 703
LEU A 751
SER A 761
 None
 0.55A 5p9iA-3zfxA:
32.1		 5p9iA-3zfxA:
40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 633
ALA A 649
LYS A 651
THR A 697
GLY A 703
LEU A 751
SER A 761
PHE A 763
 None
 0.99A 5p9iA-3zfxA:
32.1		 5p9iA-3zfxA:
40.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 GLU A 623
ILE A 625
GLY A 626
ALA A 649
GLU A 668
GLY A 703
ASP A 762
 None
 0.76A 5vc3A-3zfxA:
25.8		 5vc3A-3zfxA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 633
ALA A 649
LYS A 651
GLY A 703
LEU A 751
ASP A 762
 None
 0.88A 5yu9D-3zfxA:
31.0		 5yu9D-3zfxA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 GLY A 673
ILE A 671
TYR A 740
HIS A 677
TYR A 734
 None
 1.40A 6bp4B-3zfxA:
undetectable		 6bp4B-3zfxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		9 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
ILE A 681
THR A 697
MET A 700
GLY A 703
LEU A 751
 None
 0.89A 6bsdA-3zfxA:
30.1		 6bsdA-3zfxA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_1
(GLUCOAMYLASE P)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 836
TYR A 841
TRP A 861
GLY A 811
TRP A 826
 None
 1.44A 6fhwA-3zfxA:
undetectable		 6fhwA-3zfxA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_B_ACRB801_1
(GLUCOAMYLASE P)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 836
TYR A 841
TRP A 861
GLY A 811
TRP A 826
 None
 1.43A 6fhwB-3zfxA:
undetectable		 6fhwB-3zfxA:
13.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		8 / 12 ILE A 625
VAL A 633
ALA A 649
GLU A 668
MET A 700
GLY A 703
LEU A 751
SER A 761
 None
 0.65A 6fnmA-3zfxA:
39.1		 6fnmA-3zfxA:
85.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		11 / 12 ILE A 625
VAL A 633
ALA A 649
LYS A 651
GLU A 668
MET A 672
ILE A 695
THR A 697
MET A 700
GLY A 703
LEU A 751
 None
 0.58A 6fnmA-3zfxA:
39.1		 6fnmA-3zfxA:
85.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 633
ALA A 649
GLU A 668
MET A 672
ILE A 695
THR A 697
PHE A 699
 None
 0.73A 6hd6A-3zfxA:
31.6		 6hd6A-3zfxA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3zfx EPHRIN TYPE-B
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 633
ALA A 649
LYS A 651
GLU A 668
MET A 672
ILE A 695
PHE A 699
 None
 0.84A 6hd6A-3zfxA:
31.6		 6hd6A-3zfxA:
13.69