SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zg6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 8 HIS A 117
HIS A  93
LEU A 211
THR A  49
 None
 1.01A 1azmA-3zg6A:
undetectable		 1azmA-3zg6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 8 HIS A 117
HIS A  93
LEU A 211
THR A  49
 None
 1.00A 1bzmA-3zg6A:
undetectable		 1bzmA-3zg6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 LEU A  35
LEU A  38
VAL A  39
SER A  42
LEU A  96
 None
 1.25A 1db1A-3zg6A:
undetectable		 1db1A-3zg6A:
23.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 6 ALA A  51
SER A  54
PHE A  62
ASN A 112
ASP A 114
 APR  A1296 (-3.7A)
None
APR  A1296 (-3.6A)
None
None
 0.73A 1yc2A-3zg6A:
21.7		 1yc2A-3zg6A:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 5 ALA A  51
PHE A  62
ASN A 112
ASP A 114
 APR  A1296 (-3.7A)
APR  A1296 (-3.6A)
None
None
 0.67A 1yc2D-3zg6A:
21.8		 1yc2D-3zg6A:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 ILE A  59
PHE A  62
ASN A 112
ASP A 114
 None
APR  A1296 (-3.6A)
None
None
 0.28A 1yc2E-3zg6A:
22.5		 1yc2E-3zg6A:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 7 ALA A  51
SER A  54
ILE A  59
ASN A 112
ASP A 114
 APR  A1296 (-3.7A)
None
None
None
None
 0.36A 1yc5A-3zg6A:
23.7		 1yc5A-3zg6A:
34.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 SER A  54
ILE A  59
ASP A  61
ASP A 114
 None
None
GOL  A1299 ( 3.1A)
None
 0.81A 1yc5A-3zg6A:
23.7		 1yc5A-3zg6A:
34.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 5 ALA A  51
ILE A  59
ASN A 112
ASP A 114
 APR  A1296 (-3.7A)
None
None
None
 0.33A 2h4jA-3zg6A:
23.9		 2h4jA-3zg6A:
34.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 LEU A 267
LEU A 263
LEU A 211
VAL A 237
VAL A  45
 None
 1.26A 2qd4A-3zg6A:
undetectable		 2qd4A-3zg6A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 LEU A 267
LEU A 263
LEU A 211
VAL A 237
VAL A  45
 None
 1.04A 2qd4B-3zg6A:
undetectable		 2qd4B-3zg6A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 LEU A 108
THR A 213
GLY A 212
GLY A  52
LEU A  96
 None
APR  A1296 (-3.7A)
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
 1.02A 2uvnA-3zg6A:
undetectable		 2uvnA-3zg6A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 PHE A 107
PRO A 191
LEU A 195
ALA A 198
 None
 1.13A 2vcvA-3zg6A:
undetectable		 2vcvA-3zg6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 THR A  82
ILE A  59
GLY A  58
HIS A  93
 None
 0.82A 2y7wC-3zg6A:
undetectable		 2y7wC-3zg6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 VAL A 259
HIS A 266
LEU A  28
ILE A 209
 None
 1.00A 3avpA-3zg6A:
undetectable		 3avpA-3zg6A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		3 / 3 THR A  49
SER A 110
PHE A  62
 None
None
APR  A1296 (-3.6A)
 0.88A 3d4sA-3zg6A:
undetectable		 3d4sA-3zg6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 SER A 202
ALA A 205
GLY A 232
HIS A  48
VAL A  46
 None
 1.18A 3f8wA-3zg6A:
undetectable		 3f8wA-3zg6A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 4 PRO A  89
THR A  90
GLY A 212
THR A 213
 None
None
APR  A1296 (-3.6A)
APR  A1296 (-3.7A)
 1.05A 3ib1A-3zg6A:
undetectable		 3ib1A-3zg6A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 LEU A  35
LEU A  38
VAL A  39
SER A  42
LEU A  96
 None
 1.33A 3m7rA-3zg6A:
undetectable		 3m7rA-3zg6A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 ASN A 112
ILE A  59
PHE A  80
PHE A  62
 None
None
None
APR  A1296 (-3.6A)
 1.27A 3tvxB-3zg6A:
undetectable		 3tvxB-3zg6A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		3 / 3 GLY A 132
THR A 182
ASN A 133
 None
 0.69A 3v4tD-3zg6A:
undetectable		 3v4tD-3zg6A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 8 HIS A 117
HIS A  93
LEU A 211
THR A  49
 None
 0.99A 3w6hA-3zg6A:
undetectable		 3w6hA-3zg6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 4 ASN A 112
ALA A  51
GLY A  50
THR A 213
 None
APR  A1296 (-3.7A)
APR  A1296 (-3.2A)
APR  A1296 (-3.7A)
 1.20A 4bboC-3zg6A:
undetectable		 4bboC-3zg6A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
None
 1.10A 4e3aA-3zg6A:
4.6		 4e3aA-3zg6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
None
 1.07A 4jkuB-3zg6A:
4.6		 4jkuB-3zg6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 11 HIS A 117
HIS A  93
LEU A 263
LEU A 211
THR A  49
 None
 1.20A 4k0sA-3zg6A:
undetectable		 4k0sA-3zg6A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 11 HIS A 117
HIS A  93
LEU A 263
LEU A 211
THR A  49
 None
 1.26A 4k0sA-3zg6A:
undetectable		 4k0sA-3zg6A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
None
 1.09A 4k8pA-3zg6A:
4.7		 4k8pA-3zg6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
None
 1.09A 4k8pB-3zg6A:
4.7		 4k8pB-3zg6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
None
 1.08A 4k8tA-3zg6A:
3.4		 4k8tA-3zg6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
None
 1.09A 4k8tB-3zg6A:
4.8		 4k8tB-3zg6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
None
 1.09A 4k93A-3zg6A:
3.2		 4k93A-3zg6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
None
 1.08A 4k9cA-3zg6A:
4.7		 4k9cA-3zg6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
None
 1.09A 4k9cB-3zg6A:
3.4		 4k9cB-3zg6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
None
 1.08A 4kadA-3zg6A:
3.2		 4kadA-3zg6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
None
 1.09A 4kadB-3zg6A:
3.2		 4kadB-3zg6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
None
 1.09A 4lbxA-3zg6A:
4.9		 4lbxA-3zg6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
None
 1.10A 4lbxB-3zg6A:
4.9		 4lbxB-3zg6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
None
 1.08A 4lc4A-3zg6A:
4.6		 4lc4A-3zg6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		5 / 12 ILE A  53
GLY A 212
GLY A  52
THR A  90
LEU A 116
 None
APR  A1296 (-3.6A)
APR  A1296 (-3.3A)
None
None
 1.09A 4lc4B-3zg6A:
4.8		 4lc4B-3zg6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 ILE A  59
PHE A  62
ASN A 112
ASP A 114
 None
APR  A1296 (-3.6A)
None
None
 0.30A 4rmjA-3zg6A:
18.7		 4rmjA-3zg6A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 7 ASP A 114
PRO A  89
THR A  90
SER A  57
 None
 1.32A 5b6iA-3zg6A:
1.1		 5b6iA-3zg6A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 5 ASP A 185
GLU A 138
ARG A 180
THR A 182
 None
 1.05A 5uxcA-3zg6A:
undetectable		 5uxcA-3zg6A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens) 		4 / 5 THR A 242
ARG A 251
THR A  55
ASP A 114
 None
None
APR  A1296 ( 3.1A)
None
 1.33A 6ecxA-3zg6A:
2.9		 6ecxA-3zg6A:
24.13