SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zgj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		5 / 12 ALA A  22
LEU A 262
PHE A  42
LEU A  40
LEU A 337
 None
 0.94A 1xdkF-3zgjA:
undetectable		 1xdkF-3zgjA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		5 / 12 ALA A 109
ALA A 201
ILE A 231
PHE A 197
LEU A 235
 None
 1.22A 2nyrA-3zgjA:
undetectable		 2nyrA-3zgjA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		5 / 12 THR A 134
ALA A 114
PHE A 202
TYR A 198
ILE A 141
 None
 1.20A 2nyrA-3zgjA:
undetectable		 2nyrA-3zgjA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		5 / 12 ASN A 312
ILE A 247
ILE A 236
PHE A 338
HIS A 261
 None
None
RMN  A1369 ( 4.8A)
None
CO  A1368 ( 3.3A)
 1.42A 2qmjA-3zgjA:
undetectable		 2qmjA-3zgjA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		4 / 4 VAL A  81
ASP A 140
LEU A  95
ARG A  57
 None
 1.50A 2ziaA-3zgjA:
undetectable		 2ziaA-3zgjA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		6 / 11 ILE A  19
ILE A 141
ALA A  22
VAL A 182
VAL A 184
GLY A 258
 None
 1.38A 3kw4A-3zgjA:
undetectable		 3kw4A-3zgjA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		4 / 8 ASP A 240
PRO A 244
PRO A 238
GLU A 237
 None
 1.06A 3oyaA-3zgjA:
undetectable		 3oyaA-3zgjA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		4 / 5 GLY A 349
ASP A 318
ARG A 348
GLN A 343
 None
 1.08A 3qx3B-3zgjA:
undetectable		 3qx3B-3zgjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		4 / 8 ARG A 142
GLY A 258
PHE A 138
SER A  91
 None
 1.05A 3tzfB-3zgjA:
undetectable		 3tzfB-3zgjA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		4 / 7 TYR A  84
ASP A 140
HIS A 143
HIS A  88
 None
 1.39A 3zodA-3zgjA:
undetectable		 3zodA-3zgjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		4 / 5 SER A  59
THR A  72
TYR A  25
ASP A  94
 None
 1.31A 3zs3A-3zgjA:
undetectable		 3zs3A-3zgjA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		4 / 6 ARG A 142
HIS A 143
LEU A 145
ASP A  94
 None
 1.46A 4cevA-3zgjA:
undetectable
4cevB-3zgjA:
undetectable		 4cevA-3zgjA:
25.97
4cevB-3zgjA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		4 / 6 ASP A  94
ARG A 142
HIS A 143
LEU A 145
 None
 1.44A 4cevA-3zgjA:
undetectable
4cevC-3zgjA:
undetectable		 4cevA-3zgjA:
25.97
4cevC-3zgjA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		4 / 6 ARG A 142
HIS A 143
LEU A 145
ASP A  94
 None
 1.42A 4cevD-3zgjA:
undetectable
4cevE-3zgjA:
undetectable		 4cevD-3zgjA:
25.97
4cevE-3zgjA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		4 / 6 ARG A 142
HIS A 143
LEU A 145
ASP A  94
 None
 1.44A 4cevE-3zgjA:
undetectable
4cevF-3zgjA:
undetectable		 4cevE-3zgjA:
25.97
4cevF-3zgjA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		3 / 3 TYR A 291
THR A 286
GLU A 310
 None
 0.78A 4df3A-3zgjA:
undetectable		 4df3A-3zgjA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		3 / 3 TYR A 291
THR A 286
GLU A 310
 None
 0.79A 4df3B-3zgjA:
undetectable		 4df3B-3zgjA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		5 / 12 VAL A 259
LEU A 337
SER A  91
ALA A  22
LEU A  95
 None
 1.10A 4rrwA-3zgjA:
undetectable		 4rrwA-3zgjA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		5 / 12 VAL A 259
LEU A 337
SER A  91
ALA A  22
LEU A  95
 None
 1.10A 4rrwB-3zgjA:
undetectable		 4rrwB-3zgjA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		5 / 12 VAL A 259
LEU A 337
SER A  91
ALA A  22
LEU A  95
 None
 1.10A 4rrzA-3zgjA:
undetectable		 4rrzA-3zgjA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		5 / 12 VAL A 259
LEU A 337
SER A  91
ALA A  22
LEU A  95
 None
 1.10A 4rrzB-3zgjA:
undetectable		 4rrzB-3zgjA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		4 / 8 SER A  91
TYR A  84
ILE A 247
GLY A 256
 None
 0.65A 5alcL-3zgjA:
undetectable		 5alcL-3zgjA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		5 / 12 VAL A 259
LEU A 337
SER A  91
ALA A  22
LEU A  95
 None
 1.13A 5jvzB-3zgjA:
undetectable		 5jvzB-3zgjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		4 / 8 LEU A 323
ILE A 236
THR A 234
GLN A 260
 None
RMN  A1369 ( 4.8A)
RMN  A1369 (-3.2A)
RMN  A1369 ( 4.7A)
 0.98A 5ljbA-3zgjA:
undetectable		 5ljbA-3zgjA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		5 / 12 VAL A 259
ALA A 114
PHE A  97
PHE A 202
VAL A 224
 None
 1.28A 5tudD-3zgjA:
undetectable		 5tudD-3zgjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		4 / 8 LEU A 358
ILE A 236
PHE A 233
ALA A 263
 RMN  A1369 ( 4.1A)
RMN  A1369 ( 4.8A)
None
CO  A1368 ( 4.4A)
 0.85A 5y7pC-3zgjA:
undetectable		 5y7pC-3zgjA:
20.05