SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zgq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		5 / 12 LEU A 272
MET A 289
ARG A 333
SER A 282
TYR A 250
 None
 1.49A 1ot7B-3zgqA:
undetectable		 1ot7B-3zgqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		4 / 7 LEU A 272
LEU A 271
ILE A 241
TYR A 254
 None
 1.19A 2hc4A-3zgqA:
undetectable		 2hc4A-3zgqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		4 / 6 LEU A 475
LYS A 463
ALA A 461
PRO A 466
 None
 1.07A 3gv1A-3zgqA:
undetectable
3gv1C-3zgqA:
undetectable		 3gv1A-3zgqA:
16.55
3gv1C-3zgqA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		4 / 6 LEU A 475
LYS A 463
ALA A 461
PRO A 466
 None
 1.04A 3gv1A-3zgqA:
undetectable
3gv1B-3zgqA:
undetectable		 3gv1A-3zgqA:
16.55
3gv1B-3zgqA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		3 / 3 TYR A 155
LEU A 167
LYS A 165
 None
 0.74A 3sueD-3zgqA:
undetectable		 3sueD-3zgqA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		3 / 3 LYS A 313
LYS A 309
PRO A 308
 None
 1.24A 4dv1L-3zgqA:
undetectable		 4dv1L-3zgqA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		4 / 6 ILE A 182
TYR A 254
TYR A 250
PHE A 220
 None
 0.79A 4g10A-3zgqA:
undetectable		 4g10A-3zgqA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		3 / 3 TRP A  97
GLN A  76
THR A  96
 None
 0.92A 4m2xA-3zgqA:
undetectable		 4m2xA-3zgqA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		4 / 6 LEU A 242
ILE A 245
LEU A 271
TYR A 259
 None
 0.97A 4w5nA-3zgqA:
undetectable		 4w5nA-3zgqA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		4 / 6 ALA A  77
GLN A  76
LEU A  51
LEU A  42
 None
 1.20A 4xoyA-3zgqA:
undetectable		 4xoyA-3zgqA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		4 / 6 ALA A  77
GLN A  76
LEU A  51
LEU A  42
 None
 1.18A 4xp3A-3zgqA:
undetectable		 4xp3A-3zgqA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		4 / 5 LEU A 167
ALA A 207
ASN A 211
ILE A 178
 None
 1.06A 4y03B-3zgqA:
undetectable		 4y03B-3zgqA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		4 / 6 ASP A 189
TYR A 156
PHE A 220
TYR A 185
 None
 1.41A 5e2iA-3zgqA:
undetectable		 5e2iA-3zgqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		5 / 12 GLY A 118
LEU A  13
LEU A  14
GLU A  15
LEU A  16
 None
 1.20A 5nwwA-3zgqA:
undetectable		 5nwwA-3zgqA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		5 / 12 ALA A 101
ALA A 161
ALA A 159
LEU A  24
THR A  96
 None
 0.92A 5tl8A-3zgqA:
0.5		 5tl8A-3zgqA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		3 / 3 HIS A 398
HIS A 399
ARG A 362
 None
 1.02A 6b58A-3zgqA:
4.8		 6b58A-3zgqA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens) 		4 / 5 GLU A 448
VAL A 444
LEU A 404
HIS A 376
 None
 1.38A 6dyoA-3zgqA:
undetectable		 6dyoA-3zgqA:
11.13