SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zh2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		9 / 9 VAL A  10
GLY A  11
ASP A  35
ILE A  36
TYR A  67
ALA A  80
PHE A  82
ILE A 105
GLU A 108
 None
 0.52A 1cetA-3zh2A:
51.6		 1cetA-3zh2A:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 9 GLU A 308
ARG A 311
ALA A 181
HIS A 182
PRO A 128
 None
 1.34A 1mj2C-3zh2A:
undetectable		 1mj2C-3zh2A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 9 GLU A 308
ARG A 311
ALA A 181
HIS A 182
PRO A 128
 None
 1.41A 1mjoA-3zh2A:
undetectable		 1mjoA-3zh2A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 9 GLU A 308
ARG A 311
ALA A 181
HIS A 182
PRO A 128
 None
 1.37A 1mjoB-3zh2A:
undetectable		 1mjoB-3zh2A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 9 GLU A 308
ARG A 311
ALA A 181
HIS A 182
PRO A 128
 None
 1.36A 1mjoC-3zh2A:
undetectable		 1mjoC-3zh2A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 6 LEU A 294
GLU A 291
THR A 262
TYR A 192
 None
 1.33A 1qvuA-3zh2A:
undetectable		 1qvuA-3zh2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 GLY A  13
ILE A 243
VAL A 237
GLY A  17
GLY A  16
 None
 0.91A 1uakA-3zh2A:
undetectable		 1uakA-3zh2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 SER A  64
SER A  62
VAL A   8
LEU A   9
GLY A  11
 None
 0.79A 1uakA-3zh2A:
undetectable		 1uakA-3zh2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 10 ASP A 155
ILE A 244
THR A 156
ILE A   7
GLY A 149
 None
 1.20A 2v0mA-3zh2A:
undetectable		 2v0mA-3zh2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 11 ILE A 244
ASN A 127
ILE A 123
VAL A  31
LEU A   9
 None
 1.20A 3a51A-3zh2A:
undetectable		 3a51A-3zh2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 ILE A 244
ASN A 127
ILE A 123
VAL A  31
LEU A   9
 None
 1.21A 3a51D-3zh2A:
undetectable		 3a51D-3zh2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 ILE A 244
ASN A 127
ILE A 123
VAL A  31
LEU A   9
 None
 1.18A 3a51E-3zh2A:
undetectable		 3a51E-3zh2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 4 LEU A 315
MET A 106
ILE A 306
ASP A 272
 None
 1.35A 3hecA-3zh2A:
undetectable		 3hecA-3zh2A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		3 / 3 TYR A 161
LEU A 189
LYS A 190
 None
 0.77A 3sueD-3zh2A:
undetectable		 3sueD-3zh2A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 ILE A 244
LEU A 281
GLY A 282
VAL A  75
ILE A 123
 None
 1.03A 4c9oA-3zh2A:
undetectable		 4c9oA-3zh2A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 ILE A 244
LEU A 281
GLY A 282
VAL A  75
ILE A 123
 None
 1.05A 4c9oB-3zh2A:
undetectable		 4c9oB-3zh2A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		3 / 3 TYR A 268
THR A 277
GLU A 298
 None
 0.48A 4df3A-3zh2A:
5.4		 4df3A-3zh2A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		3 / 3 TYR A 268
THR A 277
GLU A 298
 None
 0.49A 4df3B-3zh2A:
5.3		 4df3B-3zh2A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 8 THR A 277
VAL A 286
VAL A 289
GLN A 267
 None
 1.00A 4em2A-3zh2A:
undetectable		 4em2A-3zh2A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		3 / 3 LEU A 189
PHE A 218
ILE A 193
 None
 0.77A 5dzk1-3zh2A:
undetectable
5dzkF-3zh2A:
undetectable
5dzkM-3zh2A:
undetectable		 5dzk1-3zh2A:
2.02
5dzkF-3zh2A:
22.19
5dzkM-3zh2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		6 / 12 GLY A  87
LYS A  88
ASN A  94
LEU A  98
LEU A  99
LEU A 101
 None
 1.42A 5nwwA-3zh2A:
undetectable		 5nwwA-3zh2A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 GLY A  13
ILE A 243
VAL A 237
GLY A  17
GLY A  16
 None
 0.90A 5wyqA-3zh2A:
undetectable		 5wyqA-3zh2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3zh2 L-LACTATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 GLY A  13
ILE A 243
VAL A 237
GLY A  17
GLY A  16
 None
 0.83A 5zhmB-3zh2A:
2.3		 5zhmB-3zh2A:
20.19