SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zh4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 414
GLY A 381
GLY A   8
ALA A 412
ARG A 362
 None
 1.28A 1i9gA-3zh4A:
undetectable		 1i9gA-3zh4A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 10 GLY A 225
VAL A  39
LEU A 199
LEU A 200
ALA A  35
 None
 1.36A 1pbcA-3zh4A:
undetectable		 1pbcA-3zh4A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 174
GLY A  99
PHE A 130
TYR A  96
LEU A  28
 None
 1.17A 1qabF-3zh4A:
undetectable		 1qabF-3zh4A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 9 ILE A 353
GLY A 351
GLU A 330
GLN A 308
THR A 297
 None
 1.37A 2dtjA-3zh4A:
undetectable
2dtjB-3zh4A:
undetectable		 2dtjA-3zh4A:
17.62
2dtjB-3zh4A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		4 / 6 LEU A 314
PHE A 264
ILE A 241
ALA A 245
 None
 0.92A 2j5mA-3zh4A:
undetectable		 2j5mA-3zh4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		4 / 8 ILE A 253
LYS A 406
ILE A  16
GLU A 236
 None
 0.84A 2j9dJ-3zh4A:
undetectable
2j9dK-3zh4A:
undetectable
2j9dL-3zh4A:
undetectable		 2j9dJ-3zh4A:
16.67
2j9dK-3zh4A:
16.67
2j9dL-3zh4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 315
LEU A 316
LEU A 361
MET A 383
ILE A 324
 None
 1.05A 2pnjA-3zh4A:
undetectable		 2pnjA-3zh4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 MET A 133
ILE A 169
ILE A 215
ILE A 158
VAL A 196
 None
 1.08A 3fpjB-3zh4A:
undetectable		 3fpjB-3zh4A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 VAL A 165
ALA A 187
ILE A 215
LEU A 200
ILE A 169
 PEG  A1420 (-3.3A)
None
None
None
None
 1.13A 3qfxA-3zh4A:
undetectable		 3qfxA-3zh4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 VAL A 165
ALA A 187
ILE A 215
LEU A 200
ILE A 169
 PEG  A1420 (-3.3A)
None
None
None
None
 1.13A 3qfxB-3zh4A:
undetectable		 3qfxB-3zh4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		4 / 7 ASN A 255
PRO A 232
ARG A 234
ALA A 237
 None
 0.90A 3twpA-3zh4A:
undetectable		 3twpA-3zh4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		4 / 7 ASN A 255
PRO A 232
ARG A 234
ALA A 237
 None
 0.99A 3twpB-3zh4A:
undetectable		 3twpB-3zh4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 PHE A 130
TYR A  96
ASN A  89
MET A 144
LEU A 146
 None
 1.23A 4a83A-3zh4A:
undetectable		 4a83A-3zh4A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		3 / 3 TYR A 159
MET A 160
ILE A 169
 None
 0.58A 4c8bB-3zh4A:
undetectable		 4c8bB-3zh4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A 240
LEU A 407
ILE A   4
GLY A 381
GLY A   8
 None
 1.25A 4hfpB-3zh4A:
undetectable		 4hfpB-3zh4A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		3 / 3 ASP A 326
ARG A  92
THR A 297
 None
FLC  A1419 ( 4.0A)
None
 0.74A 4i13A-3zh4A:
undetectable		 4i13A-3zh4A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 9 ALA A 175
ILE A 184
ALA A 132
ALA A 156
ILE A 158
 None
 0.99A 4lbgB-3zh4A:
undetectable		 4lbgB-3zh4A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		4 / 5 ARG A 234
ASP A 306
GLU A 236
VAL A 378
 None
FLC  A1419 (-3.0A)
None
None
 1.37A 4nkvB-3zh4A:
undetectable		 4nkvB-3zh4A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		4 / 5 ASP A 326
ARG A 398
ARG A  92
THR A 297
 None
FLC  A1419 (-2.9A)
FLC  A1419 ( 4.0A)
None
 1.27A 4p3qA-3zh4A:
undetectable		 4p3qA-3zh4A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		3 / 3 ASP A 326
ARG A  92
THR A 297
 None
FLC  A1419 ( 4.0A)
None
 0.74A 4p3rA-3zh4A:
undetectable		 4p3rA-3zh4A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		4 / 7 GLY A 134
ALA A 135
GLU A 131
SER A 138
 None
 0.80A 4r1zB-3zh4A:
undetectable		 4r1zB-3zh4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 108
GLY A 103
ALA A 132
MET A 133
GLY A 134
 None
 1.14A 4r29A-3zh4A:
undetectable		 4r29A-3zh4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 108
GLY A 103
ALA A 132
MET A 133
GLY A 134
 None
 1.18A 4r29B-3zh4A:
undetectable		 4r29B-3zh4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 108
GLY A 103
ALA A 132
MET A 133
GLY A 134
 None
 1.14A 4r29C-3zh4A:
undetectable		 4r29C-3zh4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 11 SER A  24
GLU A 192
ASP A 195
ARG A 234
ILE A  47
 None
 1.48A 4urnB-3zh4A:
undetectable		 4urnB-3zh4A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 GLU A 192
GLY A 302
ALA A 298
ILE A 328
ASP A 233
 None
 1.23A 4xe5A-3zh4A:
undetectable		 4xe5A-3zh4A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		4 / 8 TYR A  96
GLY A 166
TYR A 300
ALA A 304
 None
PEG  A1420 (-2.7A)
None
None
 0.87A 5albL-3zh4A:
undetectable		 5albL-3zh4A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 250
LEU A 268
PHE A 303
ILE A 295
PHE A 264
 None
 1.00A 5eskA-3zh4A:
undetectable		 5eskA-3zh4A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 371
ALA A 375
ILE A 282
ILE A 235
LEU A 268
 FLC  A1419 (-4.0A)
None
None
None
None
 1.10A 5h8tA-3zh4A:
undetectable		 5h8tA-3zh4A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 371
ALA A 375
ILE A 282
ILE A 235
LEU A 268
 FLC  A1419 (-4.0A)
None
None
None
None
 1.15A 5hbsA-3zh4A:
undetectable		 5hbsA-3zh4A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		4 / 8 HIS A 335
GLN A 308
LEU A 339
THR A 239
 None
 1.16A 5hs6A-3zh4A:
undetectable		 5hs6A-3zh4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		4 / 5 ILE A 253
PHE A 264
SER A 242
ALA A 237
 None
 1.19A 5msdA-3zh4A:
undetectable		 5msdA-3zh4A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 361
ALA A 380
LEU A 377
ILE A 346
ALA A 344
 None
 1.29A 5nm5B-3zh4A:
undetectable		 5nm5B-3zh4A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A   4
LEU A 407
VAL A 366
ALA A 246
GLY A 248
 None
 1.12A 5uxdB-3zh4A:
undetectable		 5uxdB-3zh4A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A 300
ILE A 215
MET A 172
HIS A 260
LEU A 257
 None
 1.25A 5y2tA-3zh4A:
undetectable		 5y2tA-3zh4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Streptococcus
pneumoniae) 		4 / 8 HIS A 154
GLY A 152
LEU A 102
GLY A 106
 None
 0.86A 6mdqA-3zh4A:
undetectable		 6mdqA-3zh4A:
13.31