SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zh9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3zh9 DELTA
(Bacillus
subtilis) 		4 / 6 LEU B 333
GLN B 217
ILE B 237
PHE B 238
 None
 1.21A 2jn3A-3zh9B:
undetectable		 2jn3A-3zh9B:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3zh9 DELTA
(Bacillus
subtilis) 		3 / 3 LEU B  27
TYR B  26
GLN B  29
 None
 0.73A 2wekA-3zh9B:
2.7		 2wekA-3zh9B:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3zh9 DELTA
(Bacillus
subtilis) 		5 / 12 LEU B  86
ALA B 133
VAL B  78
ILE B  79
LEU B  54
 None
GOL  B1347 ( 4.3A)
None
None
None
 1.28A 3uvvB-3zh9B:
undetectable		 3uvvB-3zh9B:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 3zh9 DELTA
(Bacillus
subtilis) 		5 / 12 LEU B 222
LEU B 334
LEU B 337
ILE B 251
ILE B 255
 None
 0.98A 4odrA-3zh9B:
undetectable
4odrB-3zh9B:
undetectable		 4odrA-3zh9B:
13.54
4odrB-3zh9B:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3zh9 DELTA
(Bacillus
subtilis) 		5 / 9 PRO B  83
LEU B 102
VAL B  17
VAL B  78
LEU B 134
 None
 1.35A 4puoA-3zh9B:
0.0		 4puoA-3zh9B:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3zh9 DELTA
(Bacillus
subtilis) 		4 / 6 VAL B  17
CYH B  19
HIS B 137
LEU B 134
 None
None
GOL  B1347 (-3.8A)
None
 1.22A 5hrqH-3zh9B:
undetectable
5hrqK-3zh9B:
undetectable
5hrqL-3zh9B:
undetectable		 5hrqH-3zh9B:
6.25
5hrqK-3zh9B:
4.52
5hrqL-3zh9B:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 3zh9 DELTA
(Bacillus
subtilis) 		5 / 12 PHE B 195
ILE B 196
ALA B 171
VAL B 207
ILE B 202
 None
 1.33A 5mlmA-3zh9B:
undetectable		 5mlmA-3zh9B:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3zh9 DELTA
(Bacillus
subtilis) 		3 / 3 GLU B 188
HIS B 181
VAL B 178
 None
SO4  B1340 ( 3.9A)
None
 0.86A 5trqB-3zh9B:
undetectable		 5trqB-3zh9B:
20.91