SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zhb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3zhb R-IMINE REDUCTASE
(Streptomyces
kanamyceticus) 		6 / 11 SER A  76
ALA A  35
ALA A  52
ALA A  53
THR A  45
LEU A  58
 None
 1.38A 1jinA-3zhbA:
undetectable		 1jinA-3zhbA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3zhb R-IMINE REDUCTASE
(Streptomyces
kanamyceticus) 		4 / 8 ASP A 130
SER A 157
TYR A 175
HIS A 180
 None
 1.37A 2bteD-3zhbA:
2.5		 2bteD-3zhbA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 3zhb R-IMINE REDUCTASE
(Streptomyces
kanamyceticus) 		5 / 12 ALA A 188
ASP A 179
GLY A 134
LEU A 109
LEU A 185
 None
 1.20A 2nv4A-3zhbA:
undetectable		 2nv4A-3zhbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 3zhb R-IMINE REDUCTASE
(Streptomyces
kanamyceticus) 		5 / 12 ALA A 188
GLY A 134
LEU A 109
ASP A 187
LEU A 185
 None
 1.13A 2nv4A-3zhbA:
undetectable		 2nv4A-3zhbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 3zhb R-IMINE REDUCTASE
(Streptomyces
kanamyceticus) 		6 / 12 ALA A 188
ASP A 179
GLY A 134
LEU A 109
ASP A 187
LEU A 185
 None
 1.25A 2nv4B-3zhbA:
undetectable		 2nv4B-3zhbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3zhb R-IMINE REDUCTASE
(Streptomyces
kanamyceticus) 		5 / 12 GLY A 139
LEU A 109
VAL A  80
ALA A 138
GLY A 167
 NAP  A1307 ( 4.4A)
None
None
None
None
 0.94A 2vmyA-3zhbA:
undetectable		 2vmyA-3zhbA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3zhb R-IMINE REDUCTASE
(Streptomyces
kanamyceticus) 		5 / 12 GLY A 139
LEU A 109
VAL A  80
ALA A 138
GLY A 168
 NAP  A1307 ( 4.4A)
None
None
None
None
 0.99A 2vmyA-3zhbA:
undetectable		 2vmyA-3zhbA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3zhb R-IMINE REDUCTASE
(Streptomyces
kanamyceticus) 		4 / 5 ALA A 158
PRO A 155
TYR A 131
ALA A 121
 None
 1.37A 3twpD-3zhbA:
undetectable		 3twpD-3zhbA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 3zhb R-IMINE REDUCTASE
(Streptomyces
kanamyceticus) 		4 / 7 ASP A 130
SER A 157
TYR A 175
HIS A 180
 None
 1.30A 4arcA-3zhbA:
undetectable		 4arcA-3zhbA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3zhb R-IMINE REDUCTASE
(Streptomyces
kanamyceticus) 		5 / 12 TYR A  86
GLY A 112
LEU A  34
GLY A 167
LEU A 152
 None
 1.33A 4ze1A-3zhbA:
undetectable		 4ze1A-3zhbA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3zhb R-IMINE REDUCTASE
(Streptomyces
kanamyceticus) 		5 / 12 TYR A  86
GLY A 112
LEU A  34
GLY A 170
LEU A 152
 None
 1.15A 4ze1A-3zhbA:
undetectable		 4ze1A-3zhbA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3zhb R-IMINE REDUCTASE
(Streptomyces
kanamyceticus) 		5 / 11 TYR A 131
LEU A 101
LEU A 152
LEU A  78
LEU A 166
 None
 1.01A 4zowA-3zhbA:
1.1		 4zowA-3zhbA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3zhb R-IMINE REDUCTASE
(Streptomyces
kanamyceticus) 		5 / 12 ALA A  88
LEU A  92
PHE A  38
GLY A 167
THR A 173
 NAP  A1307 (-3.6A)
NAP  A1307 (-4.5A)
None
None
None
 1.16A 5eshA-3zhbA:
undetectable		 5eshA-3zhbA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 3zhb R-IMINE REDUCTASE
(Streptomyces
kanamyceticus) 		5 / 12 TYR A  86
LEU A 191
GLY A 134
ALA A 135
LEU A 137
 None
 0.99A 5zwrA-3zhbA:
undetectable		 5zwrA-3zhbA:
23.13