SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zhe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3zhe PROTEIN SMG-7
(Caenorhabditis
elegans) 		3 / 3 TRP B   5
HIS B  28
MET B  32
 None
 1.49A 1l5qB-3zheB:
undetectable		 1l5qB-3zheB:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
(Caenorhabditis
elegans) 		4 / 7 GLU A  95
LEU A  99
MET A  47
LEU A  43
 None
 1.10A 1linA-3zheA:
undetectable		 1linA-3zheA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
(Caenorhabditis
elegans) 		3 / 3 ARG A 145
ILE A  62
TRP A  61
 None
 1.16A 1m8eB-3zheA:
undetectable		 1m8eB-3zheA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3zhe PROTEIN SMG-7
(Caenorhabditis
elegans) 		4 / 4 SER B 265
VAL B 284
PHE B 208
VAL B 184
 None
 1.19A 1o86A-3zheB:
undetectable		 1o86A-3zheB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 3zhe PROTEIN SMG-7
(Caenorhabditis
elegans) 		5 / 12 TYR B 292
LEU B 296
LEU B 299
ILE B 387
ILE B 318
 None
 1.09A 1tw4B-3zheB:
undetectable		 1tw4B-3zheB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
(Caenorhabditis
elegans) 		5 / 10 ALA A 248
LEU A 183
LEU A 206
ASN A 207
LEU A 186
 None
 1.15A 2xn6A-3zheA:
undetectable
2xn6B-3zheA:
undetectable		 2xn6A-3zheA:
23.14
2xn6B-3zheA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 3zhe PROTEIN SMG-7
(Caenorhabditis
elegans) 		4 / 5 LEU B  82
ILE B 159
ARG B 126
TYR B 152
 None
 1.49A 2zlcA-3zheB:
undetectable		 2zlcA-3zheB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
(Caenorhabditis
elegans) 		5 / 12 SER A 353
ASN A 357
GLY A 131
ASN A 109
ASP A 114
 None
 1.45A 3a27A-3zheA:
undetectable		 3a27A-3zheA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
PROTEIN SMG-7
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		4 / 5 TYR A 132
ARG A 135
THR B 107
LEU B 106
 None
 1.38A 3ag1J-3zheA:
undetectable		 3ag1J-3zheA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
(Caenorhabditis
elegans) 		3 / 3 ARG A 145
ILE A  62
TRP A  61
 None
 1.16A 3e68A-3zheA:
undetectable		 3e68A-3zheA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
(Caenorhabditis
elegans) 		3 / 3 ARG A 145
ILE A  62
TRP A  61
 None
 1.18A 3e6tB-3zheA:
undetectable		 3e6tB-3zheA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
(Caenorhabditis
elegans) 		3 / 3 LEU A  85
MET A 119
ASP A 114
 None
 0.75A 3v5wA-3zheA:
undetectable		 3v5wA-3zheA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3zhe PROTEIN SMG-7
(Caenorhabditis
elegans) 		4 / 8 GLY B 171
LEU B 172
ILE B 173
ARG B 141
 None
 0.71A 4em2A-3zheB:
undetectable		 4em2A-3zheB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
PROTEIN SMG-7
(Caenorhabditis
elegans) 		4 / 6 GLY A  91
GLU A  92
GLN A 125
MET B  30
 None
 1.01A 4g0vB-3zheA:
undetectable		 4g0vB-3zheA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
(Caenorhabditis
elegans) 		5 / 10 TRP A 292
ILE A 293
TRP A 323
LEU A 315
LEU A 300
 None
 1.41A 4jtqA-3zheA:
undetectable		 4jtqA-3zheA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
(Caenorhabditis
elegans) 		4 / 5 PHE A  72
THR A  87
PHE A  89
ILE A  82
 None
 1.18A 4jx1E-3zheA:
undetectable		 4jx1E-3zheA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
(Caenorhabditis
elegans) 		3 / 3 LYS A 103
ASN A 109
ASP A 101
 None
 0.81A 4o1eA-3zheA:
undetectable		 4o1eA-3zheA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
PROTEIN SMG-7
(Caenorhabditis
elegans) 		4 / 5 PHE A  69
PHE A  72
LEU B  77
PRO B  23
 None
 1.41A 4o8zA-3zheA:
undetectable		 4o8zA-3zheA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
(Caenorhabditis
elegans) 		4 / 7 GLU A 298
LEU A 355
TYR A 374
ARG A 246
 None
 0.86A 4twdF-3zheA:
undetectable
4twdJ-3zheA:
undetectable		 4twdF-3zheA:
22.53
4twdJ-3zheA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 3zhe PROTEIN SMG-7
(Caenorhabditis
elegans) 		5 / 12 LEU B  77
ALA B  78
LEU B  82
TRP B  50
LEU B  53
 None
 1.03A 4xi3C-3zheB:
undetectable		 4xi3C-3zheB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3zhe PROTEIN SMG-7
(Caenorhabditis
elegans) 		5 / 12 VAL B 244
GLU B 251
GLY B 250
ILE B 260
SER B 256
 None
 1.37A 4xudA-3zheB:
undetectable		 4xudA-3zheB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3zhe PROTEIN SMG-7
(Caenorhabditis
elegans) 		5 / 12 ILE B 233
LEU B 270
SER B 201
HIS B 187
GLY B 231
 None
 1.12A 5l6eA-3zheB:
undetectable		 5l6eA-3zheB:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
(Caenorhabditis
elegans) 		3 / 3 SER A 291
SER A 294
PHE A 367
 None
 0.91A 5mugA-3zheA:
undetectable		 5mugA-3zheA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
PROTEIN SMG-7
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		4 / 5 TYR A 132
ARG A 135
THR B 107
LEU B 106
 None
 1.34A 5x1fW-3zheA:
undetectable		 5x1fW-3zheA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
(Caenorhabditis
elegans) 		5 / 12 LEU A 165
MET A 110
GLY A 144
ALA A 172
LEU A 251
 None
 1.08A 5x23A-3zheA:
undetectable		 5x23A-3zheA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3zhe PROTEIN SMG-7
(Caenorhabditis
elegans) 		5 / 12 LEU B 230
GLU B 258
PRO B 262
THR B 188
GLY B 164
 None
 1.28A 5xipA-3zheB:
undetectable		 5xipA-3zheB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
(Caenorhabditis
elegans) 		3 / 3 GLY A  22
THR A  24
GLU A  25
 None
 0.56A 6b58A-3zheA:
4.7		 6b58A-3zheA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
PROTEIN SMG-7
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		4 / 5 TYR A 132
ARG A 135
THR B 107
LEU B 106
 None
 1.30A 6nknJ-3zheA:
undetectable		 6nknJ-3zheA:
10.45