SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zhy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  25
SER A  20
LEU A  44
THR A  53
LEU A  54
 None
 1.21A 1a8uA-3zhyA:
4.2		 1a8uA-3zhyA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  25
SER A  20
LEU A  44
THR A  53
LEU A  54
 None
 1.23A 1a8uB-3zhyA:
4.5		 1a8uB-3zhyA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		4 / 7 MET A 267
PRO A 149
ALA A 274
ALA A 126
 FM6  A 501 (-3.8A)
None
None
NDP  A 601 (-3.4A)
 1.00A 1k5qA-3zhyA:
undetectable
1k5qB-3zhyA:
2.5		 1k5qA-3zhyA:
19.19
1k5qB-3zhyA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 131
SER A 130
THR A 113
ALA A 142
ALA A 141
 None
 1.30A 1wygA-3zhyA:
2.5		 1wygA-3zhyA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 157
ASN A 218
ILE A 237
PHE A 230
 None
FM6  A 501 (-3.4A)
None
None
 1.16A 2jn3A-3zhyA:
undetectable		 2jn3A-3zhyA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 131
SER A 130
ALA A 142
ALA A 141
 None
 0.88A 3ax9B-3zhyA:
undetectable		 3ax9B-3zhyA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  18
GLY A  19
GLY A  22
SER A  23
LEU A 104
 None
NDP  A 601 (-3.2A)
NDP  A 601 (-3.2A)
NDP  A 601 (-3.3A)
NDP  A 601 (-4.6A)
 0.95A 3cjtO-3zhyA:
6.3		 3cjtO-3zhyA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 139
GLY A 135
SER A 136
LEU A 131
HIS A 227
 None
 1.11A 3e23A-3zhyA:
4.5		 3e23A-3zhyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 139
GLY A 319
GLY A 135
SER A 136
LEU A 131
 None
 1.05A 3e23A-3zhyA:
4.5		 3e23A-3zhyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 139
GLY A 320
GLY A 135
LEU A 131
HIS A 227
 None
 1.05A 3e23A-3zhyA:
4.5		 3e23A-3zhyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 108
GLY A 206
PRO A 207
MET A 208
 NDP  A 601 ( 4.6A)
NDP  A 601 (-3.8A)
None
None
 1.02A 3hcrA-3zhyA:
3.0		 3hcrA-3zhyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		6 / 12 VAL A 138
SER A 136
LEU A 221
ALA A 133
SER A 130
LEU A 110
 None
 1.14A 4coxA-3zhyA:
undetectable		 4coxA-3zhyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 138
LEU A 221
ALA A 133
SER A 130
LEU A 110
 None
 1.10A 4coxB-3zhyA:
undetectable		 4coxB-3zhyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 138
SER A 136
LEU A 221
ALA A 133
LEU A 110
 None
 1.08A 4coxB-3zhyA:
undetectable		 4coxB-3zhyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		6 / 12 VAL A 138
SER A 136
LEU A 221
ALA A 133
SER A 130
LEU A 110
 None
 1.15A 4coxD-3zhyA:
undetectable		 4coxD-3zhyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 347
ALA A 334
GLU A 332
GLY A 106
ASN A 330
 None
 1.43A 4jdsD-3zhyA:
undetectable		 4jdsD-3zhyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 347
ALA A 334
GLU A 332
GLY A 106
ASN A 330
 None
 1.33A 4jlgB-3zhyA:
undetectable		 4jlgB-3zhyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 329
ILE A 350
VAL A 386
ALA A 335
ALA A 334
 None
 1.06A 4lbgB-3zhyA:
5.9		 4lbgB-3zhyA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 326
LEU A 301
LEU A 311
LEU A 355
ALA A 329
 None
 1.16A 4rtbA-3zhyA:
undetectable		 4rtbA-3zhyA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 379
GLN A 375
GLU A 331
 None
 0.72A 4tvtA-3zhyA:
undetectable		 4tvtA-3zhyA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 101
ILE A 147
GLY A 145
LEU A 275
ALA A 274
 None
 1.09A 5h5fA-3zhyA:
undetectable		 5h5fA-3zhyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 101
ALA A 126
ILE A 147
LEU A 123
 None
NDP  A 601 (-3.4A)
None
None
 0.84A 5te8A-3zhyA:
undetectable		 5te8A-3zhyA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 281
ALA A 285
PRO A  36
ALA A 284
GLY A 283
 None
 1.12A 5tzoA-3zhyA:
undetectable		 5tzoA-3zhyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 9 ILE A 350
ILE A 347
GLU A 380
VAL A 386
ILE A 342
 None
 1.45A 6hloA-3zhyA:
7.6		 6hloA-3zhyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 302
LEU A 301
ARG A 313
 None
 0.83A 7dfrA-3zhyA:
undetectable		 7dfrA-3zhyA:
17.51