SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zi5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 3zi5 RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		4 / 8 SER A 325
LEU A 327
ILE A 301
THR A 321
 None
 0.89A 1sbrA-3zi5A:
undetectable		 1sbrA-3zi5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 3zi5 RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		5 / 12 LEU A 285
ILE A 304
ALA A 303
ILE A 213
LEU A 205
 None
 1.01A 3vrmA-3zi5A:
undetectable		 3vrmA-3zi5A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3zi5 RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		4 / 8 ASN A 260
TYR A 312
GLU A 313
TYR A 330
 None
 1.21A 4mj8A-3zi5A:
undetectable
4mj8C-3zi5A:
undetectable		 4mj8A-3zi5A:
19.90
4mj8C-3zi5A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3zi5 RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		4 / 7 GLU A 313
ILE A 304
LEU A 241
ILE A 257
 None
 0.95A 4xumA-3zi5A:
undetectable		 4xumA-3zi5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 3zi5 RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		5 / 12 ILE A 304
PHE A 237
PHE A 342
ASP A 236
ILE A 257
 None
 1.45A 6dwnB-3zi5A:
undetectable		 6dwnB-3zi5A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 3zi5 RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		4 / 5 GLN A 223
THR A 219
THR A 293
GLY A 224
 None
 1.12A 6gbnC-3zi5A:
undetectable		 6gbnC-3zi5A:
18.36