SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zid'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 7 LEU A 296
THR A 299
GLY A 271
LEU A 320
 None
 0.88A 1gtiA-3zidA:
undetectable		 1gtiA-3zidA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 10 LEU A 202
ALA A  19
VAL A 197
GLY A  13
GLY A   8
 None
 1.00A 1k6cA-3zidA:
undetectable		 1k6cA-3zidA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 6 ARG A  42
ILE A  46
PHE A 103
GLU A  98
 None
 1.46A 1nsiA-3zidA:
undetectable
1nsiB-3zidA:
undetectable		 1nsiA-3zidA:
20.74
1nsiB-3zidA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 6 PHE A 103
GLU A  98
ARG A  42
ILE A  46
 None
 1.48A 1nsiA-3zidA:
undetectable
1nsiB-3zidA:
undetectable		 1nsiA-3zidA:
20.74
1nsiB-3zidA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 6 PHE A 103
GLU A  98
ARG A  42
ILE A  46
 None
 1.49A 1nsiC-3zidA:
undetectable
1nsiD-3zidA:
undetectable		 1nsiC-3zidA:
20.74
1nsiD-3zidA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 12 LEU A  17
ILE A 193
ASN A  14
ALA A  47
PHE A 107
 None
GDP  A 999 (-3.5A)
None
None
None
 1.15A 2ejtA-3zidA:
2.5		 2ejtA-3zidA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 7 ARG A  42
ILE A  46
PHE A 103
GLU A  98
 None
 1.39A 2nsiA-3zidA:
0.6
2nsiB-3zidA:
0.6		 2nsiA-3zidA:
20.74
2nsiB-3zidA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 7 PHE A 103
GLU A  98
ARG A  42
ILE A  46
 None
 1.44A 2nsiA-3zidA:
0.6
2nsiB-3zidA:
0.6		 2nsiA-3zidA:
20.74
2nsiB-3zidA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 7 ARG A  42
ILE A  46
PHE A 103
GLU A  98
 None
 1.46A 2nsiC-3zidA:
0.6
2nsiD-3zidA:
undetectable		 2nsiC-3zidA:
20.74
2nsiD-3zidA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 7 PHE A 103
GLU A  98
ARG A  42
ILE A  46
 None
 1.45A 2nsiC-3zidA:
0.6
2nsiD-3zidA:
undetectable		 2nsiC-3zidA:
20.74
2nsiD-3zidA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 12 LEU A  17
ASN A  21
ALA A  24
ARG A 315
MET A 109
 None
 1.40A 2oaxC-3zidA:
undetectable		 2oaxC-3zidA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 5 VAL A  69
THR A  50
VAL A  75
GLY A  82
 None
 1.10A 2p2fA-3zidA:
2.8		 2p2fA-3zidA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 4 VAL A  69
THR A  50
VAL A  75
GLY A  82
 None
 1.10A 2p2fB-3zidA:
3.8		 2p2fB-3zidA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 11 ALA A 207
SER A 210
GLU A 211
GLY A 306
ILE A 307
 None
 1.26A 2uxpB-3zidA:
undetectable		 2uxpB-3zidA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 8 GLY A 115
GLY A  10
ILE A  48
SER A 119
 GDP  A 999 (-3.7A)
GDP  A 999 (-3.5A)
None
None
 0.68A 3d41A-3zidA:
2.6		 3d41A-3zidA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		3 / 3 ALA A 141
THR A 110
CYH A 159
 None
 0.58A 3e4eA-3zidA:
undetectable		 3e4eA-3zidA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		3 / 3 ALA A 141
THR A 110
CYH A 159
 None
 0.62A 3e4eB-3zidA:
undetectable		 3e4eB-3zidA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 7 ARG A  42
ILE A  46
PHE A 103
GLU A  98
 None
 1.43A 3e7gA-3zidA:
undetectable
3e7gB-3zidA:
undetectable		 3e7gA-3zidA:
22.79
3e7gB-3zidA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 7 PHE A 103
GLU A  98
ARG A  42
ILE A  46
 None
 1.45A 3e7gA-3zidA:
undetectable
3e7gB-3zidA:
undetectable		 3e7gA-3zidA:
22.79
3e7gB-3zidA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 7 ARG A  42
ILE A  46
PHE A 103
GLU A  98
 None
 1.43A 3e7gC-3zidA:
undetectable
3e7gD-3zidA:
undetectable		 3e7gC-3zidA:
22.79
3e7gD-3zidA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 11 ALA A 270
ILE A 300
GLY A 301
LEU A 320
ALA A 273
 None
 0.84A 3kw2B-3zidA:
2.9		 3kw2B-3zidA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 12 LEU A 173
GLY A 327
ALA A 325
LEU A 229
LEU A 331
 None
 1.01A 3p5nA-3zidA:
undetectable		 3p5nA-3zidA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 12 LEU A 173
GLY A 327
ALA A 325
LEU A 229
LEU A 331
 None
 1.01A 3p5nB-3zidA:
undetectable		 3p5nB-3zidA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		3 / 3 PHE A 107
GLN A  23
PHE A 221
 None
 0.83A 3rv5A-3zidA:
undetectable		 3rv5A-3zidA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		3 / 3 LEU A 320
MET A 225
ASP A 220
 None
 0.53A 3v5wA-3zidA:
undetectable		 3v5wA-3zidA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 7 PHE A 103
GLU A  98
ARG A  42
ILE A  46
 None
 1.44A 4cx7C-3zidA:
undetectable
4cx7D-3zidA:
undetectable		 4cx7C-3zidA:
20.74
4cx7D-3zidA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 11 GLY A 114
TYR A 152
SER A 118
TYR A 190
GLY A  10
 GDP  A 999 (-3.3A)
GDP  A 999 ( 4.4A)
None
GDP  A 999 (-3.4A)
GDP  A 999 (-3.5A)
 1.48A 4ey7A-3zidA:
3.1		 4ey7A-3zidA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 11 GLY A 114
TYR A 152
SER A 118
TYR A 190
GLY A  10
 GDP  A 999 (-3.3A)
GDP  A 999 ( 4.4A)
None
GDP  A 999 (-3.4A)
GDP  A 999 (-3.5A)
 1.48A 4ey7B-3zidA:
3.7		 4ey7B-3zidA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 5 VAL A 138
LEU A 105
VAL A   4
PHE A 107
 None
 1.02A 4lb0B-3zidA:
undetectable		 4lb0B-3zidA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 12 GLU A 292
GLU A 288
GLU A 294
GLY A 306
ILE A 309
 None
 1.27A 4xe5A-3zidA:
2.8		 4xe5A-3zidA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 6 GLY A 117
THR A 116
SER A 121
VAL A   9
 GDP  A 999 (-3.5A)
GDP  A 999 (-4.3A)
None
None
 1.13A 5ewuB-3zidA:
2.3		 5ewuB-3zidA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 12 THR A 223
GLY A 170
ILE A 164
ASP A 169
ALA A 168
 None
 1.20A 5kvaA-3zidA:
4.2		 5kvaA-3zidA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 12 THR A 223
GLY A 170
ILE A 164
ASP A 169
ALA A 168
 None
 1.22A 5kvaB-3zidA:
2.0		 5kvaB-3zidA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		5 / 10 LEU A   7
GLY A  10
GLY A  13
ILE A  93
LEU A  67
 None
GDP  A 999 (-3.5A)
None
None
None
 1.04A 5l0zB-3zidA:
undetectable		 5l0zB-3zidA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 3zid TUBULIN/FTSZ, GTPASE
(Methanothrix
thermoacetophila) 		4 / 8 LEU A 128
VAL A   9
LEU A   7
ILE A  48
 None
 0.78A 6cb4A-3zidA:
undetectable		 6cb4A-3zidA:
23.00