SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ziz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 6 PRO A 170
TRP A  56
GLU A 205
TRP A 114
 None
GOL  A1351 (-3.9A)
None
TRS  A1352 ( 4.7A)
 1.24A 1ffyA-3zizA:
0.7		 1ffyA-3zizA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 GLU A 205
LEU A 209
GLY A 208
PHE A 207
ALA A 264
 None
 1.26A 1hvyA-3zizA:
undetectable		 1hvyA-3zizA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 GLU A 275
ILE A 107
LEU A 166
ASP A 236
LEU A 199
 None
 1.12A 1hvyD-3zizA:
undetectable		 1hvyD-3zizA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 ILE A 148
ILE A 187
TYR A 190
GLN A 141
ALA A 140
 None
 1.38A 1ki7A-3zizA:
undetectable		 1ki7A-3zizA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		3 / 3 GLU A 276
ASN A  25
TRP A  56
 TRS  A1352 (-2.8A)
None
GOL  A1351 (-3.9A)
 1.17A 1r15C-3zizA:
undetectable		 1r15C-3zizA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		3 / 3 GLU A 276
ASN A  25
TRP A  56
 TRS  A1352 (-2.8A)
None
GOL  A1351 (-3.9A)
 1.22A 1r15D-3zizA:
1.9		 1r15D-3zizA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		3 / 3 GLU A 276
ASN A  25
TRP A  56
 TRS  A1352 (-2.8A)
None
GOL  A1351 (-3.9A)
 1.18A 1r15E-3zizA:
2.1		 1r15E-3zizA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		3 / 3 GLU A 276
ASN A  25
TRP A  56
 TRS  A1352 (-2.8A)
None
GOL  A1351 (-3.9A)
 1.17A 1r15F-3zizA:
undetectable		 1r15F-3zizA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 LEU A  95
LEU A  92
ILE A  45
THR A  24
ILE A 161
 None
 1.14A 1tw4A-3zizA:
undetectable		 1tw4A-3zizA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		3 / 3 ASN A  87
TRP A  71
GLN A  90
 None
 1.42A 1xoqA-3zizA:
undetectable		 1xoqA-3zizA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 GLN A 309
TYR A 243
TRP A  56
GLU A 169
 None
TRS  A1352 ( 4.5A)
GOL  A1351 (-3.9A)
TRS  A1352 (-2.8A)
 1.30A 2aowA-3zizA:
1.7		 2aowA-3zizA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		3 / 3 ARG A 283
GLU A 280
GLN A 287
 None
 1.09A 2p16A-3zizA:
undetectable		 2p16A-3zizA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 GLN A 143
TYR A 123
TYR A 190
ILE A 191
 None
 1.23A 2ph9A-3zizA:
undetectable
2ph9B-3zizA:
undetectable		 2ph9A-3zizA:
20.98
2ph9B-3zizA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 GLN A 143
TYR A 147
TYR A 190
ILE A 191
 None
 1.20A 2ph9A-3zizA:
undetectable
2ph9B-3zizA:
undetectable		 2ph9A-3zizA:
20.98
2ph9B-3zizA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		6 / 12 ASN A 168
GLU A 169
HIS A 241
TYR A 243
GLU A 276
TRP A 308
 TRS  A1352 (-2.7A)
TRS  A1352 (-2.8A)
None
TRS  A1352 ( 4.5A)
TRS  A1352 (-2.8A)
TRS  A1352 (-3.7A)
 0.80A 2v3dA-3zizA:
8.3		 2v3dA-3zizA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 11 ASN A 168
GLU A 169
TYR A 243
GLU A 276
TRP A 308
 TRS  A1352 (-2.7A)
TRS  A1352 (-2.8A)
TRS  A1352 ( 4.5A)
TRS  A1352 (-2.8A)
TRS  A1352 (-3.7A)
 0.84A 2v3dB-3zizA:
3.0		 2v3dB-3zizA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 LEU A 209
ASP A 225
THR A 224
TRP A 114
 None
None
None
TRS  A1352 ( 4.7A)
 1.16A 3ablC-3zizA:
undetectable
3ablN-3zizA:
undetectable
3ablP-3zizA:
undetectable		 3ablC-3zizA:
19.27
3ablN-3zizA:
20.23
3ablP-3zizA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 LEU A 209
ASP A 225
THR A 224
TRP A 114
 None
None
None
TRS  A1352 ( 4.7A)
 1.19A 3asnC-3zizA:
undetectable
3asnN-3zizA:
undetectable
3asnP-3zizA:
undetectable		 3asnC-3zizA:
19.27
3asnN-3zizA:
20.23
3asnP-3zizA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 ASP A 225
THR A 224
TRP A 114
LEU A 209
 None
None
TRS  A1352 ( 4.7A)
None
 1.21A 3asoA-3zizA:
undetectable
3asoC-3zizA:
undetectable
3asoP-3zizA:
undetectable		 3asoA-3zizA:
20.23
3asoC-3zizA:
19.27
3asoP-3zizA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 LEU A 106
ALA A  46
ALA A  22
VAL A  38
THR A  41
 None
 1.11A 3c6gB-3zizA:
undetectable		 3c6gB-3zizA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 LEU A 106
ALA A  46
ALA A  22
VAL A  38
THR A  41
 None
 1.11A 3czhB-3zizA:
undetectable		 3czhB-3zizA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 10 ILE A 180
VAL A 179
TYR A 144
VAL A 111
LEU A 235
 None
 1.16A 3em0A-3zizA:
undetectable		 3em0A-3zizA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 GLU A 275
ILE A 107
LEU A 166
ASP A 236
LEU A 199
 None
 1.14A 3k2hA-3zizA:
undetectable		 3k2hA-3zizA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 GLU A 275
ILE A 107
LEU A 166
ASP A 236
LEU A 199
 None
 1.15A 3k2hB-3zizA:
undetectable		 3k2hB-3zizA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 GLU A 222
LEU A 202
TRP A 183
ASN A 229
 None
 1.42A 3k8mB-3zizA:
9.4		 3k8mB-3zizA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 GLY A 254
PHE A 237
PHE A 240
PHE A 226
 None
 0.65A 3ko0D-3zizA:
undetectable
3ko0E-3zizA:
undetectable		 3ko0D-3zizA:
11.52
3ko0E-3zizA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 GLY A 256
PHE A 237
PHE A 240
PHE A 226
 None
 1.03A 3ko0D-3zizA:
undetectable
3ko0E-3zizA:
undetectable		 3ko0D-3zizA:
11.52
3ko0E-3zizA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 PHE A 240
PHE A 226
GLY A 254
PHE A 237
 None
 0.74A 3ko0B-3zizA:
undetectable
3ko0J-3zizA:
undetectable		 3ko0B-3zizA:
11.52
3ko0J-3zizA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 GLY A 256
PHE A 237
PHE A 240
PHE A 226
 None
 1.04A 3ko0K-3zizA:
undetectable
3ko0S-3zizA:
undetectable		 3ko0K-3zizA:
11.52
3ko0S-3zizA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 GLY A 254
PHE A 237
PHE A 240
PHE A 226
 None
 0.64A 3ko0L-3zizA:
undetectable
3ko0N-3zizA:
undetectable		 3ko0L-3zizA:
11.52
3ko0N-3zizA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 GLY A 256
PHE A 237
PHE A 240
PHE A 226
 None
 1.15A 3ko0L-3zizA:
undetectable
3ko0N-3zizA:
undetectable		 3ko0L-3zizA:
11.52
3ko0N-3zizA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 GLY A 254
PHE A 237
PHE A 240
PHE A 226
 None
 0.74A 3ko0M-3zizA:
undetectable
3ko0P-3zizA:
undetectable		 3ko0M-3zizA:
11.52
3ko0P-3zizA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 GLY A 254
PHE A 237
PHE A 240
PHE A 226
 None
 0.71A 3ko0O-3zizA:
undetectable
3ko0Q-3zizA:
undetectable		 3ko0O-3zizA:
11.52
3ko0Q-3zizA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 PHE A 240
PHE A 226
GLY A 254
PHE A 237
 None
 0.73A 3ko0K-3zizA:
undetectable
3ko0S-3zizA:
undetectable		 3ko0K-3zizA:
11.52
3ko0S-3zizA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 PHE A 240
PHE A 226
GLY A 254
PHE A 237
 None
 0.60A 3ko0R-3zizA:
undetectable
3ko0T-3zizA:
undetectable		 3ko0R-3zizA:
11.52
3ko0T-3zizA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 PHE A 240
PHE A 226
GLY A 256
PHE A 237
 None
 1.08A 3ko0R-3zizA:
undetectable
3ko0T-3zizA:
undetectable		 3ko0R-3zizA:
11.52
3ko0T-3zizA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 THR A  41
ILE A  45
SER A  48
ILE A  14
ALA A   5
 None
 1.22A 3vw1D-3zizA:
undetectable		 3vw1D-3zizA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 ASP A 225
THR A 224
TRP A 114
LEU A 209
 None
None
TRS  A1352 ( 4.7A)
None
 1.22A 3wg7A-3zizA:
undetectable
3wg7C-3zizA:
undetectable
3wg7P-3zizA:
undetectable		 3wg7A-3zizA:
20.23
3wg7C-3zizA:
19.27
3wg7P-3zizA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 LEU A 209
ASP A 225
THR A 224
TRP A 114
 None
None
None
TRS  A1352 ( 4.7A)
 1.22A 3wg7C-3zizA:
undetectable
3wg7N-3zizA:
undetectable
3wg7P-3zizA:
undetectable		 3wg7C-3zizA:
19.27
3wg7N-3zizA:
20.23
3wg7P-3zizA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 LEU A 209
ASP A 225
THR A 224
TRP A 114
 None
None
None
TRS  A1352 ( 4.7A)
 1.20A 3x2qC-3zizA:
undetectable
3x2qN-3zizA:
undetectable
3x2qP-3zizA:
undetectable		 3x2qC-3zizA:
19.27
3x2qN-3zizA:
20.23
3x2qP-3zizA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 THR A  24
LEU A  53
VAL A  55
GLN A 309
 None
 0.90A 4em2A-3zizA:
undetectable		 4em2A-3zizA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 GLU A 275
ILE A 107
LEU A 166
ASP A 236
LEU A 199
 None
 1.16A 4foxA-3zizA:
undetectable		 4foxA-3zizA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 GLU A 275
ILE A 107
LEU A 166
ASP A 236
LEU A 199
 None
 1.17A 4foxB-3zizA:
undetectable		 4foxB-3zizA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 GLU A 275
ILE A 107
LEU A 166
ASP A 236
LEU A 199
 None
 1.12A 4foxG-3zizA:
undetectable		 4foxG-3zizA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 ASN A  87
ARG A  91
ASN A  83
ILE A  82
 None
 0.91A 4k0bA-3zizA:
undetectable		 4k0bA-3zizA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 ASN A  87
ARG A  91
ASN A  83
ILE A  82
 None
 0.84A 4l7iA-3zizA:
undetectable		 4l7iA-3zizA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 PRO A 217
GLY A 254
PHE A 253
ASP A 260
TYR A 218
 None
 1.07A 4lxzA-3zizA:
undetectable		 4lxzA-3zizA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 PRO A 217
GLY A 254
PHE A 253
ASP A 260
TYR A 218
 None
 1.06A 4lxzC-3zizA:
undetectable		 4lxzC-3zizA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 6 GLU A 165
TYR A 113
GLU A 169
GLU A 205
 None
None
TRS  A1352 (-2.8A)
None
 1.10A 4mi4A-3zizA:
undetectable		 4mi4A-3zizA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 GLU A 165
TYR A 113
GLU A 169
GLU A 205
 None
None
TRS  A1352 (-2.8A)
None
 1.12A 4mi4B-3zizA:
undetectable
4mi4C-3zizA:
undetectable		 4mi4B-3zizA:
18.75
4mi4C-3zizA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 GLU A 165
TYR A 113
GLU A 169
GLU A 205
 None
None
TRS  A1352 (-2.8A)
None
 1.11A 4mi4A-3zizA:
undetectable
4mi4C-3zizA:
undetectable		 4mi4A-3zizA:
18.75
4mi4C-3zizA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 GLU A 165
TYR A 113
GLU A 169
GLU A 205
 None
None
TRS  A1352 (-2.8A)
None
 1.13A 4mj8A-3zizA:
0.9
4mj8C-3zizA:
undetectable		 4mj8A-3zizA:
16.80
4mj8C-3zizA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 GLU A 165
TYR A 113
GLU A 169
GLU A 205
 None
None
TRS  A1352 (-2.8A)
None
 1.12A 4mj8B-3zizA:
undetectable
4mj8C-3zizA:
undetectable		 4mj8B-3zizA:
16.80
4mj8C-3zizA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 GLU A 165
TYR A 113
GLU A 169
GLU A 205
 None
None
TRS  A1352 (-2.8A)
None
 1.21A 4mj8C-3zizA:
undetectable		 4mj8C-3zizA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		3 / 3 ASP A 305
LEU A 306
PHE A 307
 None
 0.63A 4pthA-3zizA:
undetectable		 4pthA-3zizA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		3 / 3 TYR A 279
GLY A 245
PRO A 244
 None
 0.60A 4qwpA-3zizA:
undetectable		 4qwpA-3zizA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 5 GLU A 165
TYR A 113
GLU A 169
GLU A 205
 None
None
TRS  A1352 (-2.8A)
None
 1.38A 4r87E-3zizA:
undetectable		 4r87E-3zizA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 GLU A 165
TYR A 113
GLU A 169
GLU A 205
 None
None
TRS  A1352 (-2.8A)
None
 1.33A 4r87I-3zizA:
undetectable		 4r87I-3zizA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 6 LEU A 110
LEU A 166
GLU A 165
ILE A 200
 None
 0.92A 4ww7A-3zizA:
undetectable		 4ww7A-3zizA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 ASP A 225
THR A 224
TRP A 114
LEU A 209
 None
None
TRS  A1352 ( 4.7A)
None
 1.23A 5b1aA-3zizA:
undetectable
5b1aC-3zizA:
undetectable
5b1aP-3zizA:
undetectable		 5b1aA-3zizA:
20.23
5b1aC-3zizA:
19.27
5b1aP-3zizA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 ASP A 225
THR A 224
TRP A 114
LEU A 209
 None
None
TRS  A1352 ( 4.7A)
None
 1.19A 5b1bA-3zizA:
undetectable
5b1bC-3zizA:
undetectable
5b1bP-3zizA:
undetectable		 5b1bA-3zizA:
20.23
5b1bC-3zizA:
19.27
5b1bP-3zizA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 ALA A 150
SER A 153
ARG A  74
GLN A  64
GLY A  85
 None
 1.18A 5m54E-3zizA:
undetectable		 5m54E-3zizA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 LEU A 209
ASP A 225
THR A 224
TRP A 114
 None
None
None
TRS  A1352 ( 4.7A)
 1.20A 5xdqC-3zizA:
undetectable
5xdqN-3zizA:
undetectable
5xdqP-3zizA:
undetectable		 5xdqC-3zizA:
19.27
5xdqN-3zizA:
20.23
5xdqP-3zizA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 LEU A 209
ASP A 225
THR A 224
TRP A 114
 None
None
None
TRS  A1352 ( 4.7A)
 1.24A 5z84C-3zizA:
undetectable
5z84N-3zizA:
undetectable
5z84P-3zizA:
undetectable		 5z84C-3zizA:
19.27
5z84N-3zizA:
20.23
5z84P-3zizA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 LEU A 209
ASP A 225
THR A 224
TRP A 114
 None
None
None
TRS  A1352 ( 4.7A)
 1.23A 5z85C-3zizA:
undetectable
5z85N-3zizA:
undetectable
5z85P-3zizA:
undetectable		 5z85C-3zizA:
19.27
5z85N-3zizA:
20.23
5z85P-3zizA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 LEU A 209
ASP A 225
THR A 224
TRP A 114
 None
None
None
TRS  A1352 ( 4.7A)
 1.21A 5zcoC-3zizA:
undetectable
5zcoN-3zizA:
undetectable
5zcoP-3zizA:
undetectable		 5zcoC-3zizA:
19.27
5zcoN-3zizA:
20.23
5zcoP-3zizA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 VAL A 111
TYR A 144
TYR A 135
GLU A 205
 None
 1.20A 6gneB-3zizA:
undetectable		 6gneB-3zizA:
23.47