SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zjc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 8 SER A  19
SER A  22
GLY A  66
GLY A  15
 GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
 0.68A 1aq7A-3zjcA:
undetectable		 1aq7A-3zjcA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 8 SER A  19
SER A  22
GLY A  66
GLY A  15
 GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
 0.65A 1f5lA-3zjcA:
undetectable		 1f5lA-3zjcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 6 SER A  19
SER A  22
GLY A  66
GLY A  15
 GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
 0.72A 1tnlA-3zjcA:
undetectable		 1tnlA-3zjcA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 6 SER A  19
SER A  22
GLY A  66
GLY A  15
 GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
 0.71A 2otvA-3zjcA:
undetectable		 2otvA-3zjcA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 8 SER A  19
SER A  22
GLY A  66
GLY A  15
 GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
 0.69A 2vinA-3zjcA:
undetectable		 2vinA-3zjcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		5 / 12 THR A  77
THR A  64
VAL A  12
ILE A  95
ILE A 115
 None
 1.27A 2yzqA-3zjcA:
undetectable		 2yzqA-3zjcA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		3 / 3 CYH A 165
PHE A 131
PHE A 142
 None
 1.09A 3cr5X-3zjcA:
undetectable		 3cr5X-3zjcA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		5 / 12 ASN A 196
VAL A  12
ILE A  11
ILE A 189
PRO A  92
 None
 1.21A 3kpbA-3zjcA:
undetectable		 3kpbA-3zjcA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		5 / 12 HIS A 126
ILE A  95
VAL A  12
ILE A  11
PRO A  92
 None
 1.10A 3kpbC-3zjcA:
undetectable		 3kpbC-3zjcA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 6 SER A  19
SER A  22
GLY A  66
GLY A  15
 GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
 0.68A 3rxfA-3zjcA:
undetectable		 3rxfA-3zjcA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 7 VAL A 157
ILE A 129
LEU A 137
LEU A 101
 None
 1.01A 4l1wA-3zjcA:
undetectable		 4l1wA-3zjcA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		5 / 12 LEU A 101
PHE A 131
ILE A 146
LEU A 153
ILE A 129
 None
 1.06A 4nx6A-3zjcA:
undetectable		 4nx6A-3zjcA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		5 / 12 LEU A 101
PHE A 131
ILE A 146
LEU A 153
ILE A 129
 None
 1.08A 4nx7A-3zjcA:
undetectable		 4nx7A-3zjcA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		5 / 12 LEU A 101
PHE A 131
ILE A 146
LEU A 153
ILE A 129
 None
 1.08A 4pstA-3zjcA:
undetectable		 4pstA-3zjcA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		3 / 3 ILE A 115
ILE A  85
MET A 127
 None
 0.67A 5i9yA-3zjcA:
undetectable		 5i9yA-3zjcA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		5 / 9 ILE A 156
TYR A 104
LEU A  97
THR A 111
ILE A 115
 None
 1.17A 5ifuB-3zjcA:
2.4		 5ifuB-3zjcA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		3 / 3 LYS A 173
LYS A 134
SER A 168
 None
 1.41A 5odiA-3zjcA:
2.1		 5odiA-3zjcA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		5 / 10 ALA A  94
VAL A 128
VAL A  98
THR A  27
LEU A 185
 None
 1.12A 6h1lA-3zjcA:
undetectable		 6h1lA-3zjcA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		5 / 11 ALA A  94
VAL A 128
VAL A  98
THR A  27
LEU A 185
 None
 1.11A 6h1lB-3zjcA:
undetectable		 6h1lB-3zjcA:
22.37