SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zjk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		3 / 3 ALA A 351
VAL A 353
TRP A 347
 None
 0.79A 1bdwA-3zjkA:
undetectable
1bdwB-3zjkA:
undetectable		 1bdwA-3zjkA:
3.41
1bdwB-3zjkA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 182
ALA A 187
ALA A 191
THR A 137
TYR A 118
 None
 0.97A 1cbsA-3zjkA:
undetectable		 1cbsA-3zjkA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		4 / 4 ALA A 223
VAL A 231
ALA A 234
HIS A 238
 None
 1.16A 1q23A-3zjkA:
undetectable		 1q23A-3zjkA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		4 / 4 ALA A 223
VAL A 231
ALA A 234
HIS A 238
 None
 1.21A 1q23K-3zjkA:
undetectable		 1q23K-3zjkA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_A_ADNA1001_1
(CLASS B ACID
PHOSPHATASE)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		5 / 10 PHE A 114
GLU A   6
GLY A 215
ASP A 277
THR A 112
 None
 1.37A 2b82A-3zjkA:
2.1		 2b82A-3zjkA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		4 / 7 TYR A 422
GLU A 338
THR A  14
VAL A  71
 None
GOL  A 902 (-2.5A)
None
None
 1.22A 2fb2B-3zjkA:
3.5		 2fb2B-3zjkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 182
ALA A 187
ALA A 191
THR A 137
TYR A 118
 None
 0.90A 2fr3A-3zjkA:
undetectable		 2fr3A-3zjkA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		4 / 5 ALA A 341
ASP A 389
ASP A 407
ASP A 355
 None
 1.11A 2nyuB-3zjkA:
undetectable		 2nyuB-3zjkA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		5 / 11 ASN A 163
GLU A 164
TYR A 284
GLU A 338
TRP A 385
 GOL  A 902 (-2.9A)
GOL  A 902 ( 3.4A)
None
GOL  A 902 (-2.5A)
GOL  A 902 (-3.8A)
 0.86A 2v3dB-3zjkA:
16.4		 2v3dB-3zjkA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		3 / 3 PRO A 316
GLU A 357
TYR A 361
 None
 0.75A 2zmbA-3zjkA:
undetectable		 2zmbA-3zjkA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		4 / 6 SER A 418
TYR A 422
LEU A 362
LEU A  69
 None
 0.65A 3f33A-3zjkA:
undetectable		 3f33A-3zjkA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		4 / 6 ALA A 160
ILE A 216
HIS A 199
VAL A 203
 None
 1.19A 3nneG-3zjkA:
undetectable		 3nneG-3zjkA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		4 / 7 ALA A 273
ILE A 246
HIS A 199
GLY A 200
 None
 1.01A 3v4tH-3zjkA:
undetectable		 3v4tH-3zjkA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOF_A_HQEA200_1
(FLAVOREDOXIN)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		4 / 5 TYR A 251
VAL A 262
ARG A 135
HIS A 194
 None
 1.41A 3zofA-3zjkA:
0.0		 3zofA-3zjkA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOF_B_HQEB200_1
(FLAVOREDOXIN)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		4 / 5 TYR A 251
VAL A 262
ARG A 135
HIS A 194
 None
 1.36A 3zofB-3zjkA:
0.0		 3zofB-3zjkA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		4 / 7 ASP A  45
GLY A  41
THR A 398
PHE A 395
 None
 0.84A 4ac9C-3zjkA:
3.4		 4ac9C-3zjkA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		3 / 3 ASP A 121
TRP A 385
SER A  77
 None
GOL  A 902 (-3.8A)
None
 1.01A 4lrhB-3zjkA:
undetectable		 4lrhB-3zjkA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		3 / 3 ASP A 121
TRP A 385
SER A  77
 None
GOL  A 902 (-3.8A)
None
 1.10A 4lrhF-3zjkA:
undetectable		 4lrhF-3zjkA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		3 / 3 ASN A 163
PHE A 383
TYR A  74
 GOL  A 902 (-2.9A)
None
None
 0.67A 4u15A-3zjkA:
undetectable		 4u15A-3zjkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		5 / 12 PHE A 391
PHE A 395
GLY A 172
LEU A 171
ALA A  42
 None
 1.09A 4wnwB-3zjkA:
undetectable		 4wnwB-3zjkA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		3 / 3 SER A  15
ALA A  13
VAL A  12
 GOL  A 902 ( 4.6A)
None
None
 0.56A 4x1iA-3zjkA:
3.4		 4x1iA-3zjkA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		4 / 4 LEU A 218
ILE A 216
PRO A 245
LEU A 247
 CL  A1430 ( 4.0A)
None
None
None
 1.07A 5eb3A-3zjkA:
undetectable		 5eb3A-3zjkA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		3 / 3 MET A  66
GLN A  67
ARG A  72
 None
 0.98A 5ewzB-3zjkA:
undetectable		 5ewzB-3zjkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		3 / 3 SER A  15
ALA A  13
VAL A  12
 GOL  A 902 ( 4.6A)
None
None
 0.57A 5eypA-3zjkA:
undetectable		 5eypA-3zjkA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		3 / 3 MET A  66
GLN A  67
ARG A  72
 None
 1.02A 5m35B-3zjkA:
undetectable		 5m35B-3zjkA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		3 / 3 MET A  66
GLN A  67
ARG A  72
 None
 1.05A 5m36A-3zjkA:
undetectable		 5m36A-3zjkA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		4 / 6 PRO A 245
PRO A 165
PHE A 170
LEU A 195
 None
CL  A1430 (-3.8A)
None
None
 1.22A 5tl8A-3zjkA:
undetectable		 5tl8A-3zjkA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		3 / 3 ARG A 373
ARG A 425
ARG A 371
 None
 0.85A 5vcgA-3zjkA:
undetectable		 5vcgA-3zjkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		5 / 12 ALA A 369
LEU A 370
VAL A 384
GLY A  11
THR A 112
 None
 1.15A 5x24A-3zjkA:
undetectable		 5x24A-3zjkA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 193
HIS A 194
ARG A 190
 None
 1.09A 6b58A-3zjkA:
undetectable		 6b58A-3zjkA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		3 / 3 TYR A  59
HIS A  55
PHE A  98
 None
 0.93A 6esmA-3zjkA:
undetectable		 6esmA-3zjkA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		3 / 3 MET A  66
GLN A  67
ARG A  72
 None
 1.05A 6fn9A-3zjkA:
undetectable		 6fn9A-3zjkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		3 / 3 MET A  66
GLN A  67
ARG A  72
 None
 1.08A 6fnaB-3zjkA:
undetectable		 6fnaB-3zjkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3zjk BETA GLYCOSIDASE
(Thermus
thermophilus) 		3 / 3 MET A  66
GLN A  67
ARG A  72
 None
 1.05A 6fnbA-3zjkA:
undetectable		 6fnbA-3zjkA:
21.23