SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zjl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 3zjl PROTOGLOBIN
(Methanosarcina
acetivorans) 		4 / 7 ASN A 126
TYR A  85
ASN A  82
VAL A  89
 HEM  A 200 (-4.9A)
HEM  A 200 (-4.4A)
None
HEM  A 200 (-4.5A)
 1.33A 1wu8A-3zjlA:
undetectable
1wu8C-3zjlA:
undetectable		 1wu8A-3zjlA:
20.22
1wu8C-3zjlA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3zjl PROTOGLOBIN
(Methanosarcina
acetivorans) 		4 / 4 PHE A  63
TYR A 141
ARG A  92
LEU A  57
 None
None
HEM  A 200 (-4.4A)
None
 1.06A 3sueA-3zjlA:
undetectable		 3sueA-3zjlA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3zjl PROTOGLOBIN
(Methanosarcina
acetivorans) 		4 / 7 TYR A  85
TYR A 141
PRO A 188
TYR A 189
 HEM  A 200 (-4.4A)
None
None
None
 1.06A 3ugrA-3zjlA:
undetectable		 3ugrA-3zjlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zjl PROTOGLOBIN
(Methanosarcina
acetivorans) 		4 / 6 LEU A  28
PHE A  34
LEU A 184
PHE A  20
 None
 1.04A 3wg7P-3zjlA:
undetectable
3wg7W-3zjlA:
undetectable		 3wg7P-3zjlA:
20.00
3wg7W-3zjlA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 3zjl PROTOGLOBIN
(Methanosarcina
acetivorans) 		4 / 5 TRP A 174
GLY A  46
ALA A  45
PHE A  34
 None
 1.40A 3wqwA-3zjlA:
undetectable		 3wqwA-3zjlA:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 3zjl PROTOGLOBIN
(Methanosarcina
acetivorans) 		6 / 7 TYR A  61
VAL A  64
PHE A  74
VAL A  89
PHE A  93
ILE A 149
 CYN  A 201 (-4.5A)
None
HEM  A 200 (-3.5A)
HEM  A 200 (-4.5A)
CYN  A 201 ( 4.5A)
HEM  A 200 ( 4.6A)
 0.71A 3zjqA-3zjlA:
34.0		 3zjqA-3zjlA:
99.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 3zjl PROTOGLOBIN
(Methanosarcina
acetivorans) 		6 / 7 TYR A  61
VAL A  64
PHE A  74
VAL A  89
PHE A  93
ILE A 149
 CYN  A 201 (-4.5A)
None
HEM  A 200 (-3.5A)
HEM  A 200 (-4.5A)
CYN  A 201 ( 4.5A)
HEM  A 200 ( 4.6A)
 0.69A 3zjqB-3zjlA:
34.5		 3zjqB-3zjlA:
99.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zjl PROTOGLOBIN
(Methanosarcina
acetivorans) 		4 / 5 LEU A  28
PHE A  34
LEU A 184
PHE A  20
 None
 1.14A 5iy5P-3zjlA:
undetectable
5iy5W-3zjlA:
undetectable		 5iy5P-3zjlA:
19.77
5iy5W-3zjlA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 3zjl PROTOGLOBIN
(Methanosarcina
acetivorans) 		5 / 12 ASP A 129
ARG A  92
LEU A 184
ALA A 177
ILE A 149
 None
HEM  A 200 (-4.4A)
None
None
HEM  A 200 ( 4.6A)
 0.86A 5vc0A-3zjlA:
undetectable		 5vc0A-3zjlA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zjl PROTOGLOBIN
(Methanosarcina
acetivorans) 		4 / 5 LEU A  28
PHE A  34
LEU A 184
PHE A  20
 None
 1.19A 5x1fC-3zjlA:
undetectable
5x1fJ-3zjlA:
undetectable		 5x1fC-3zjlA:
20.00
5x1fJ-3zjlA:
16.23