SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zk6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QVT_A_PRLA311_0 (TRANSCRIPTIONAL REGULATOR QACR)	3zk6	BCL-2-LIKE PROTEIN 1 (Homo sapiens)	4 / 8	LEU A 178 GLU A 179 THR A 190 ILE A 140	None	1.03A	1qvtA-3zk6A: 3.1	1qvtA-3zk6A: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OWX_B_XRAB233_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	3zk6	BCL-2-LIKE PROTEIN 1 (Homo sapiens)	5 / 11	PHE A 27 GLY A 148 GLY A 147 MET A 170 GLU A 98	None	1.28A	3owxA-3zk6A: undetectable 3owxB-3zk6A: undetectable	3owxA-3zk6A: 21.70 3owxB-3zk6A: 21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGK_A_0TXA302_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	3zk6	BCL-2-LIKE PROTEIN 1 (Homo sapiens)	4 / 7	GLY A 148 GLY A 147 MET A 170 GLU A 98	None	1.10A	4fgkB-3zk6A: undetectable	4fgkB-3zk6A: 22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGL_C_CLQC303_0 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	3zk6	BCL-2-LIKE PROTEIN 1 (Homo sapiens)	4 / 5	GLY A 148 GLY A 147 MET A 170 GLU A 98	None	1.14A	4fglC-3zk6A: undetectable	4fglC-3zk6A: 22.32

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1QVT_A_PRLA311_0","TRANSCRIPTIONAL REGULATOR QACR","3zk6","BCL-2-LIKE PROTEIN 1","Homo sapiens",4,"LEU A 178;GLU A 179;THR A 190;ILE A 140","None","1.03A","1qvtA-3zk6A:3.1","1qvtA-3zk6A:22.12"],["3OWX_B_XRAB233_1","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE];RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","3zk6","BCL-2-LIKE PROTEIN 1","Homo sapiens",5,"PHE A  27;GLY A 148;GLY A 147;MET A 170;GLU A  98","None","1.28A","3owxA-3zk6A:undetectable;3owxB-3zk6A:undetectable","3owxA-3zk6A:21.70;3owxB-3zk6A:21.70"],["4FGK_A_0TXA302_1","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","3zk6","BCL-2-LIKE PROTEIN 1","Homo sapiens",4,"GLY A 148;GLY A 147;MET A 170;GLU A  98","None","1.10A","4fgkB-3zk6A:undetectable","4fgkB-3zk6A:22.32"],["4FGL_C_CLQC303_0","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","3zk6","BCL-2-LIKE PROTEIN 1","Homo sapiens",4,"GLY A 148;GLY A 147;MET A 170;GLU A  98","None","1.14A","4fglC-3zk6A:undetectable","4fglC-3zk6A:22.32"]]