SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zkb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AJ6_A_NOVA1_1
(GYRASE)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		6 / 9 ASN A  52
GLU A  56
ASP A  79
ARG A  82
ILE A  84
PRO A  85
 ANP  A 601 ( 2.6A)
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
ANP  A 601 (-4.3A)
None
 0.75A 1aj6A-3zkbA:
27.4		 1aj6A-3zkbA:
36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 105
MET A 100
LEU A 135
GLN A 148
HIS A  89
 None
 1.34A 1aqbA-3zkbA:
undetectable		 1aqbA-3zkbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 105
MET A 100
LEU A 135
GLN A 148
HIS A  89
 None
 1.35A 1iiuA-3zkbA:
undetectable		 1iiuA-3zkbA:
15.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		7 / 12 ASP A  55
GLU A  56
ASP A  79
ARG A  82
ILE A  84
PRO A  85
ARG A 141
 None
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
ANP  A 601 (-4.3A)
None
None
 0.61A 1kijA-3zkbA:
44.2		 1kijA-3zkbA:
43.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		7 / 12 ASN A  52
GLU A  56
ASP A  79
ARG A  82
ILE A  84
PRO A  85
ARG A 141
 ANP  A 601 ( 2.6A)
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
ANP  A 601 (-4.3A)
None
None
 0.71A 1kijB-3zkbA:
44.3		 1kijB-3zkbA:
43.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		4 / 8 SER A 132
LEU A  70
ASP A  72
GLU A 211
 None
 1.20A 1mxgA-3zkbA:
undetectable		 1mxgA-3zkbA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		5 / 12 ASN A  52
ASP A  55
GLU A  56
ARG A  82
ASP A 142
 ANP  A 601 ( 2.6A)
None
ANP  A 601 (-3.9A)
None
None
 1.16A 1s14A-3zkbA:
24.1		 1s14A-3zkbA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		7 / 12 ASN A  52
ASP A  55
GLU A  56
ASP A  79
ARG A  82
PRO A  85
ARG A 141
 ANP  A 601 ( 2.6A)
None
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
None
None
 0.50A 1s14A-3zkbA:
24.1		 1s14A-3zkbA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		5 / 12 ASN A  52
ASP A  55
GLU A  56
ARG A  82
ASP A 142
 ANP  A 601 ( 2.6A)
None
ANP  A 601 (-3.9A)
None
None
 1.14A 1s14B-3zkbA:
26.0		 1s14B-3zkbA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		7 / 12 ASN A  52
ASP A  55
GLU A  56
ASP A  79
ARG A  82
PRO A  85
ARG A 141
 ANP  A 601 ( 2.6A)
None
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
None
None
 0.54A 1s14B-3zkbA:
26.0		 1s14B-3zkbA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 125
ASN A 129
VAL A 171
ILE A  84
 ANP  A 601 (-3.8A)
None
None
ANP  A 601 (-4.3A)
 0.96A 1z2bC-3zkbA:
undetectable		 1z2bC-3zkbA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 172
ASP A  79
ASP A  55
 None
ANP  A 601 (-3.7A)
None
 0.89A 2ejtA-3zkbA:
undetectable		 2ejtA-3zkbA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 354
LEU A 392
ILE A 289
ALA A 290
 None
 0.78A 2i2zA-3zkbA:
undetectable		 2i2zA-3zkbA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		5 / 12 TYR A  33
ILE A 308
GLY A 124
VAL A 127
PHE A 109
 None
None
ANP  A 601 (-3.3A)
None
None
 1.14A 2okcA-3zkbA:
undetectable		 2okcA-3zkbA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		5 / 12 TYR A  33
ILE A 308
GLY A 124
VAL A 127
PHE A 109
 None
None
ANP  A 601 (-3.3A)
None
None
 1.19A 2okcB-3zkbA:
undetectable		 2okcB-3zkbA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  49
ALA A  53
ILE A 206
LEU A  69
ILE A  46
 None
ANP  A 601 ( 4.8A)
None
None
None
 1.02A 3clbC-3zkbA:
undetectable		 3clbC-3zkbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		4 / 4 LEU A  45
ALA A 130
VAL A  26
PRO A  30
 None
 1.13A 3gv1B-3zkbA:
undetectable		 3gv1B-3zkbA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		5 / 11 VAL A  49
ALA A  53
ILE A 206
LEU A  69
ILE A  46
 None
ANP  A 601 ( 4.8A)
None
None
None
 1.06A 3hbbC-3zkbA:
undetectable		 3hbbC-3zkbA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		5 / 12 ASN A  52
ASP A  55
GLU A  56
ARG A  82
ASP A 142
 ANP  A 601 ( 2.6A)
None
ANP  A 601 (-3.9A)
None
None
 1.46A 3lpsA-3zkbA:
38.6		 3lpsA-3zkbA:
34.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		6 / 12 ASN A  52
ASP A  55
GLU A  56
ASP A  79
ARG A  82
PRO A  85
 ANP  A 601 ( 2.6A)
None
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
None
 0.39A 3lpsA-3zkbA:
38.6		 3lpsA-3zkbA:
34.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		6 / 12 ASN A  52
ASP A  55
GLU A  56
ASP A  79
PRO A  85
ARG A 141
 ANP  A 601 ( 2.6A)
None
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
None
 0.46A 3lpsA-3zkbA:
38.6		 3lpsA-3zkbA:
34.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 134
VAL A 137
GLU A 136
ASP A  97
VAL A  96
 None
 1.26A 4d9hA-3zkbA:
undetectable		 4d9hA-3zkbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 134
VAL A 137
GLU A 136
ASP A  97
VAL A  96
 None
 1.28A 4danA-3zkbA:
undetectable		 4danA-3zkbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		5 / 11 VAL A  54
LEU A 204
THR A 205
GLU A 196
THR A 307
 None
 1.22A 4e0fA-3zkbA:
undetectable		 4e0fA-3zkbA:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		6 / 11 ASN A  52
ASP A  55
GLU A  56
ASP A  79
ARG A  82
PRO A  85
 ANP  A 601 ( 2.6A)
None
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
None
 0.91A 4urnA-3zkbA:
28.4		 4urnA-3zkbA:
38.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		6 / 11 ASN A  52
ASP A  55
GLU A  56
ASP A  79
PRO A  85
ARG A 141
 ANP  A 601 ( 2.6A)
None
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
None
 0.69A 4urnA-3zkbA:
28.4		 4urnA-3zkbA:
38.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		6 / 11 ASN A  52
ASP A  55
GLU A  56
ASP A  79
ARG A  82
PRO A  85
 ANP  A 601 ( 2.6A)
None
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
None
 0.73A 4urnB-3zkbA:
26.6		 4urnB-3zkbA:
38.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		6 / 11 ASN A  52
ASP A  55
GLU A  56
ASP A  79
PRO A  85
ARG A 141
 ANP  A 601 ( 2.6A)
None
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
None
 0.60A 4urnB-3zkbA:
26.6		 4urnB-3zkbA:
38.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		6 / 11 ASN A  52
ASP A  55
GLU A  56
ASP A  79
ARG A  82
PRO A  85
 ANP  A 601 ( 2.6A)
None
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
None
 0.74A 4urnC-3zkbA:
28.9		 4urnC-3zkbA:
38.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		6 / 11 ASN A  52
ASP A  55
GLU A  56
ASP A  79
PRO A  85
ARG A 141
 ANP  A 601 ( 2.6A)
None
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
None
 0.64A 4urnC-3zkbA:
28.9		 4urnC-3zkbA:
38.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		7 / 12 ASN A  52
GLU A  56
ASP A  79
ARG A  82
ILE A  84
PRO A  85
ARG A 141
 ANP  A 601 ( 2.6A)
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
ANP  A 601 (-4.3A)
None
None
 0.70A 4uroA-3zkbA:
28.7		 4uroA-3zkbA:
39.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		6 / 12 ASN A  52
GLU A  56
ASP A  79
ARG A  82
ILE A  84
PRO A  85
 ANP  A 601 ( 2.6A)
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
ANP  A 601 (-4.3A)
None
 0.63A 4uroB-3zkbA:
28.6		 4uroB-3zkbA:
39.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		6 / 12 ASN A  52
GLU A  56
ASP A  79
ILE A  84
PRO A  85
ARG A 141
 ANP  A 601 ( 2.6A)
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
ANP  A 601 (-4.3A)
None
None
 0.63A 4uroB-3zkbA:
28.6		 4uroB-3zkbA:
39.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		6 / 12 ASN A  52
GLU A  56
ASP A  79
ARG A  82
ILE A  84
PRO A  85
 ANP  A 601 ( 2.6A)
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
ANP  A 601 (-4.3A)
None
 0.69A 4uroC-3zkbA:
28.8		 4uroC-3zkbA:
39.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		6 / 12 ASN A  52
GLU A  56
ASP A  79
ILE A  84
PRO A  85
ARG A 141
 ANP  A 601 ( 2.6A)
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
ANP  A 601 (-4.3A)
None
None
 0.66A 4uroC-3zkbA:
28.8		 4uroC-3zkbA:
39.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		7 / 12 ASN A  52
GLU A  56
ASP A  79
ARG A  82
ILE A  84
PRO A  85
ARG A 141
 ANP  A 601 ( 2.6A)
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
ANP  A 601 (-4.3A)
None
None
 0.74A 4uroD-3zkbA:
28.4		 4uroD-3zkbA:
39.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 308
VAL A 387
ILE A 358
PHE A 383
 None
 0.99A 5hieC-3zkbA:
undetectable		 5hieC-3zkbA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3zkb DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 287
GLN A 385
CYH A 388
 None
 0.91A 5icxC-3zkbA:
undetectable
5icxF-3zkbA:
undetectable		 5icxC-3zkbA:
19.21
5icxF-3zkbA:
4.18