SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zkj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3zkj ANKYRIN REPEAT AND
SOCS BOX PROTEIN 9
(Homo
sapiens) 		5 / 11 PHE A 221
LEU A 214
ALA A 191
GLY A 190
ARG A 180
 None
 1.32A 1l5rA-3zkjA:
undetectable		 1l5rA-3zkjA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3zkj ANKYRIN REPEAT AND
SOCS BOX PROTEIN 9
(Homo
sapiens) 		3 / 3 LEU A 217
LEU A 214
SER A 211
 None
None
CL  A1297 (-3.5A)
 0.68A 1tlmA-3zkjA:
undetectable		 1tlmA-3zkjA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3zkj ANKYRIN REPEAT AND
SOCS BOX PROTEIN 9
(Homo
sapiens) 		5 / 12 LEU A 171
LEU A 187
ALA A 142
SER A 201
PRO A 202
 None
 1.23A 2vmyB-3zkjA:
undetectable		 2vmyB-3zkjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3zkj ANKYRIN REPEAT AND
SOCS BOX PROTEIN 9
(Homo
sapiens) 		5 / 12 LEU A 167
GLY A 168
GLY A 196
ASP A 200
LEU A 173
 None
 1.09A 3cjtG-3zkjA:
undetectable		 3cjtG-3zkjA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 3zkj ANKYRIN REPEAT AND
SOCS BOX PROTEIN 9
(Homo
sapiens) 		4 / 4 GLY A 168
TYR A 172
GLY A 196
ASP A 200
 None
 1.35A 3kl3A-3zkjA:
undetectable		 3kl3A-3zkjA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 3zkj ANKYRIN REPEAT AND
SOCS BOX PROTEIN 9
(Homo
sapiens) 		5 / 11 ARG A 267
VAL A 183
ILE A 160
ILE A 272
ILE A 154
 None
 1.22A 5hw8B-3zkjA:
undetectable		 5hw8B-3zkjA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3zkj ANKYRIN REPEAT AND
SOCS BOX PROTEIN 9
(Homo
sapiens) 		5 / 10 ASP A 161
ALA A 155
ILE A 154
GLY A 271
GLY A 157
 None
 1.15A 5i6xA-3zkjA:
undetectable		 5i6xA-3zkjA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3zkj ANKYRIN REPEAT AND
SOCS BOX PROTEIN 9
(Homo
sapiens) 		5 / 9 ASP A 161
ALA A 155
ILE A 154
GLY A 271
GLY A 157
 None
 1.16A 6awoA-3zkjA:
undetectable		 6awoA-3zkjA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3zkj ANKYRIN REPEAT AND
SOCS BOX PROTEIN 9
(Homo
sapiens) 		5 / 9 ASP A 161
ALA A 155
ILE A 154
GLY A 271
GLY A 157
 None
 1.17A 6awqA-3zkjA:
undetectable		 6awqA-3zkjA:
17.72