SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 6 VAL C  37
LEU C  48
PHE C  63
MET C  82
 None
None
GOL  C1217 (-4.0A)
None
 1.10A 1x8vA-3zkmC:
undetectable		 1x8vA-3zkmC:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL C  24
THR C  23
ILE C  20
THR C  68
ILE C  69
 None
 1.20A 3ddyA-3zkmC:
undetectable		 3ddyA-3zkmC:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 5 TYR C  93
LEU C  80
LEU C  85
ARG C  66
 None
None
None
GOL  C1217 (-3.8A)
 1.30A 4em2A-3zkmC:
undetectable		 4em2A-3zkmC:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 8 TYR C  93
ASP C  88
PHE C  63
LEU C  48
 None
GOL  C1217 ( 4.5A)
GOL  C1217 (-4.0A)
None
 0.83A 4f8hA-3zkmC:
3.3
4f8hB-3zkmC:
undetectable		 4f8hA-3zkmC:
21.94
4f8hB-3zkmC:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 8 TYR C  93
ASP C  88
PHE C  63
LEU C  48
 None
GOL  C1217 ( 4.5A)
GOL  C1217 (-4.0A)
None
 0.84A 4f8hB-3zkmC:
undetectable
4f8hC-3zkmC:
undetectable		 4f8hB-3zkmC:
21.94
4f8hC-3zkmC:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 8 TYR C  93
ASP C  88
PHE C  63
LEU C  48
 None
GOL  C1217 ( 4.5A)
GOL  C1217 (-4.0A)
None
 0.82A 4f8hC-3zkmC:
undetectable
4f8hD-3zkmC:
undetectable		 4f8hC-3zkmC:
21.94
4f8hD-3zkmC:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 8 TYR C  93
ASP C  88
PHE C  63
LEU C  48
 None
GOL  C1217 ( 4.5A)
GOL  C1217 (-4.0A)
None
 0.83A 4f8hD-3zkmC:
undetectable
4f8hE-3zkmC:
undetectable		 4f8hD-3zkmC:
21.94
4f8hE-3zkmC:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 8 PHE C  63
LEU C  48
TYR C  93
ASP C  88
 GOL  C1217 (-4.0A)
None
None
GOL  C1217 ( 4.5A)
 0.83A 4f8hA-3zkmC:
3.3
4f8hE-3zkmC:
undetectable		 4f8hA-3zkmC:
21.94
4f8hE-3zkmC:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 5 SER C 115
ALA C 117
PHE C 149
LEU C 173
ASP C 176
 None
 0.37A 5mthA-3zkmC:
27.3		 5mthA-3zkmC:
63.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		3 / 3 SER C 206
ALA C 201
VAL C 200
 None
 0.53A 5xiwC-3zkmC:
undetectable		 5xiwC-3zkmC:
18.26