SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zl8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		4 / 8 THR A 113
PRO A 114
GLY A 115
LEU A 152
 None
 0.78A 1h4oG-3zl8A:
undetectable		 1h4oG-3zl8A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE210_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		5 / 9 MET A 337
GLU A 350
SER A 319
GLU A 314
ALA A 169
 None
None
ADP  A1441 ( 4.0A)
None
None
 1.29A 1wrlE-3zl8A:
undetectable
1wrlF-3zl8A:
undetectable		 1wrlE-3zl8A:
12.73
1wrlF-3zl8A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		3 / 3 LEU A 125
PRO A 124
LEU A 128
 None
 0.55A 2po7B-3zl8A:
4.4		 2po7B-3zl8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		3 / 3 THR A 183
SER A  90
LYS A  93
 None
None
ADP  A1441 (-2.8A)
 1.11A 3aocC-3zl8A:
undetectable		 3aocC-3zl8A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		5 / 11 VAL A 138
LEU A 139
GLY A  86
ILE A 187
PRO A 158
 None
 1.26A 3bjwB-3zl8A:
undetectable		 3bjwB-3zl8A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		5 / 11 VAL A 138
LEU A 139
GLY A  86
ILE A 187
PRO A 158
 None
 1.26A 3bjwH-3zl8A:
1.0		 3bjwH-3zl8A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		4 / 7 VAL A  54
THR A  53
ILE A  59
ILE A  47
 None
 0.73A 3deuA-3zl8A:
undetectable		 3deuA-3zl8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		4 / 5 ALA A 161
LEU A 164
GLY A  89
THR A 119
 None
ADP  A1441 ( 4.9A)
None
None
 0.95A 3dl9A-3zl8A:
undetectable		 3dl9A-3zl8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		5 / 10 VAL A 160
VAL A 162
LEU A 164
GLY A  86
VAL A 138
 None
None
ADP  A1441 ( 4.9A)
None
None
 1.08A 3ls4H-3zl8A:
undetectable		 3ls4H-3zl8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		4 / 8 ILE A 180
SER A  91
GLY A 167
SER A 312
 None
ADP  A1441 (-4.0A)
None
None
 0.85A 3lslA-3zl8A:
undetectable
3lslD-3zl8A:
undetectable		 3lslA-3zl8A:
21.90
3lslD-3zl8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		4 / 8 SER A 312
ILE A 180
SER A  91
GLY A 167
 None
None
ADP  A1441 (-4.0A)
None
 0.94A 3lslA-3zl8A:
undetectable
3lslD-3zl8A:
undetectable		 3lslA-3zl8A:
21.90
3lslD-3zl8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		3 / 3 LYS A 374
GLU A 349
TRP A 372
 None
 0.95A 3v4tH-3zl8A:
1.6		 3v4tH-3zl8A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		5 / 11 ALA A 197
PHE A 219
LEU A 100
VAL A  85
THR A 216
 None
 1.47A 4eilE-3zl8A:
4.1		 4eilE-3zl8A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		5 / 12 ASP A 203
ALA A 267
PHE A 218
GLY A 220
THR A 216
 None
 1.31A 4mm4A-3zl8A:
undetectable		 4mm4A-3zl8A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		5 / 12 ASP A 203
ALA A 267
PHE A 218
GLY A 220
THR A 216
 None
 1.29A 4mm4B-3zl8A:
undetectable		 4mm4B-3zl8A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		5 / 12 ASP A 203
ALA A 267
PHE A 218
GLY A 220
THR A 216
 None
 1.30A 4mm6A-3zl8A:
undetectable		 4mm6A-3zl8A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		4 / 4 TYR A 233
THR A 238
GLY A 236
LEU A 303
 None
 0.96A 4w5nA-3zl8A:
2.0		 4w5nA-3zl8A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		5 / 10 ASP A   3
ALA A  44
VAL A  21
ASP A  20
GLY A  19
 None
 1.37A 4xp1A-3zl8A:
undetectable		 4xp1A-3zl8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		4 / 5 SER A  90
ARG A 343
GLY A 341
GLU A 342
 None
 1.14A 5btiA-3zl8A:
undetectable
5btiB-3zl8A:
2.2		 5btiA-3zl8A:
21.17
5btiB-3zl8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		4 / 5 SER A  90
ARG A 343
GLY A 341
GLU A 342
 None
 1.08A 5btiC-3zl8A:
undetectable
5btiD-3zl8A:
2.0		 5btiC-3zl8A:
21.17
5btiD-3zl8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		5 / 12 PHE A 249
LEU A 103
LEU A 287
PHE A 242
ALA A 267
 None
 1.30A 5ieoA-3zl8A:
undetectable		 5ieoA-3zl8A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE
(Thermotoga
maritima) 		4 / 5 SER A 407
VAL A 410
GLY A 335
ALA A 336
 None
 1.02A 5k50A-3zl8A:
6.7		 5k50A-3zl8A:
21.15