SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zla'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 3zla NUCLEOPROTEIN
(Bunyamwera
orthobunyavirus) 		5 / 10 ARG A 101
GLU A  20
ALA A  22
PHE A  26
GLY A  89
 None
 1.14A 1cmcA-3zlaA:
undetectable
1cmcB-3zlaA:
undetectable		 1cmcA-3zlaA:
21.76
1cmcB-3zlaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3zla NUCLEOPROTEIN
(Bunyamwera
orthobunyavirus) 		4 / 7 TYR A  43
PHE A  42
LEU A  90
PHE A  26
 None
 1.05A 2vcvA-3zlaA:
undetectable		 2vcvA-3zlaA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 3zla NUCLEOPROTEIN
(Bunyamwera
orthobunyavirus) 		5 / 9 ILE A 122
TYR A  36
LEU A  99
LEU A 103
LYS A 106
 None
 1.18A 3f78A-3zlaA:
undetectable		 3f78A-3zlaA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 3zla NUCLEOPROTEIN
(Bunyamwera
orthobunyavirus) 		4 / 6 ILE A  39
PRO A 125
GLY A  46
VAL A  72
 None
U  I  19 ( 3.9A)
U  I  18 ( 4.7A)
None
 0.77A 3n3iA-3zlaA:
undetectable		 3n3iA-3zlaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 3zla NUCLEOPROTEIN
(Bunyamwera
orthobunyavirus) 		3 / 3 VAL A 208
TYR A 158
ALA A 161
 None
 0.51A 4ybnA-3zlaA:
undetectable		 4ybnA-3zlaA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 3zla NUCLEOPROTEIN
(Bunyamwera
orthobunyavirus) 		4 / 7 TYR A  43
GLY A  97
SER A  96
LEU A  95
 None
 1.13A 5bphB-3zlaA:
undetectable		 5bphB-3zlaA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 3zla NUCLEOPROTEIN
(Bunyamwera
orthobunyavirus) 		5 / 9 ILE A  41
GLU A  48
ARG A  47
ILE A  49
GLY A  46
 None
None
U  I  18 ( 4.2A)
None
U  I  18 ( 4.7A)
 1.22A 5ifuB-3zlaA:
undetectable		 5ifuB-3zlaA:
17.97