SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zlb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		4 / 6 LEU A 389
GLU A 385
LEU A 392
VAL A 189
 None
 1.18A 1sn5A-3zlbA:
undetectable		 1sn5A-3zlbA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		4 / 6 LYS A 171
LEU A   4
GLU A 170
VAL A  16
 None
 0.94A 1sn5A-3zlbA:
undetectable		 1sn5A-3zlbA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		3 / 3 ILE A 362
ASP A 356
PHE A 326
 None
ANP  A1401 (-3.4A)
None
 0.45A 1uwjB-3zlbA:
undetectable		 1uwjB-3zlbA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 177
ASN A 180
ALA A 183
MET A   1
LEU A 392
 GOL  A1404 (-3.7A)
None
None
None
None
 1.46A 1ya3A-3zlbA:
undetectable		 1ya3A-3zlbA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 177
ASN A 180
ALA A 183
MET A   1
LEU A 392
 GOL  A1404 (-3.7A)
None
None
None
None
 1.46A 1ya3B-3zlbA:
undetectable		 1ya3B-3zlbA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 12 VAL A 211
LEU A 215
VAL A 222
THR A 335
GLY A 353
 None
 1.17A 2cbrA-3zlbA:
undetectable		 2cbrA-3zlbA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		4 / 7 TYR A 233
GLY A 225
THR A 229
TYR A 230
 None
None
None
ANP  A1401 ( 4.7A)
 1.03A 2g70A-3zlbA:
undetectable		 2g70A-3zlbA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		4 / 7 TYR A 233
GLY A 225
THR A 229
TYR A 230
 None
None
None
ANP  A1401 ( 4.7A)
 1.00A 2g70B-3zlbA:
2.7		 2g70B-3zlbA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 177
ASN A 180
ALA A 183
MET A   1
LEU A 392
 GOL  A1404 (-3.7A)
None
None
None
None
 1.45A 2oaxC-3zlbA:
undetectable		 2oaxC-3zlbA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 201
SER A 203
LEU A 223
VAL A 338
ILE A 299
 None
ANP  A1401 (-3.6A)
None
None
None
 1.19A 2wa2A-3zlbA:
undetectable		 2wa2A-3zlbA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 379
GLU A 382
LEU A 392
LEU A 389
LEU A 178
 None
 1.17A 3erdA-3zlbA:
undetectable		 3erdA-3zlbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 10 ALA A 379
GLU A 382
LEU A 392
LEU A 389
LEU A 178
 None
 1.21A 3erdB-3zlbA:
undetectable		 3erdB-3zlbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 379
GLU A 382
LEU A 392
LEU A 389
LEU A 178
 None
 1.10A 3hm1A-3zlbA:
undetectable		 3hm1A-3zlbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		6 / 12 GLY A 296
GLY A 334
GLY A 324
THR A 335
ASP A 340
ILE A 304
 ANP  A1401 (-4.2A)
None
ANP  A1401 (-3.3A)
None
None
None
 1.45A 3p97C-3zlbA:
undetectable		 3p97C-3zlbA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 293
GLU A 292
GLY A 296
LYS A 271
ASN A 242
 None
None
ANP  A1401 (-4.2A)
None
None
 1.29A 3qowA-3zlbA:
2.4		 3qowA-3zlbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 177
ASN A 180
ALA A 183
MET A   1
LEU A 392
 GOL  A1404 (-3.7A)
None
None
None
None
 1.43A 3vhuA-3zlbA:
undetectable		 3vhuA-3zlbA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 394
THR A 396
ALA A 158
VAL A 163
VAL A 388
 None
 1.47A 4df3B-3zlbA:
4.3		 4df3B-3zlbA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		4 / 6 GLY A 376
GLY A 377
GLU A 181
ILE A 185
 GOL  A1404 (-3.0A)
None
GOL  A1404 (-2.7A)
None
 0.90A 4fglD-3zlbA:
3.9		 4fglD-3zlbA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		3 / 3 PRO A 390
ASN A 162
HIS A 159
 None
 0.86A 4ma3H-3zlbA:
undetectable
4ma3L-3zlbA:
undetectable		 4ma3H-3zlbA:
19.05
4ma3L-3zlbA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 11 VAL A 290
ALA A 289
TYR A 233
GLY A 300
GLY A 287
 None
None
None
None
MG  A1400 ( 4.3A)
 1.19A 4mm9A-3zlbA:
undetectable		 4mm9A-3zlbA:
24.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 9 VAL A 290
ALA A 289
TYR A 233
GLY A 300
GLY A 287
 None
None
None
None
MG  A1400 ( 4.3A)
 1.13A 4mmeA-3zlbA:
undetectable		 4mmeA-3zlbA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 9 VAL A 290
ALA A 289
TYR A 233
GLY A 300
GLY A 287
 None
None
None
None
MG  A1400 ( 4.3A)
 1.14A 4mmeB-3zlbA:
undetectable		 4mmeB-3zlbA:
24.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		8 / 12 GLY A 202
GLY A 226
GLY A 227
LEU A 244
PHE A 276
LEU A 297
GLY A 324
VAL A 325
 ANP  A1401 (-3.1A)
ANP  A1401 (-3.3A)
ANP  A1401 (-3.5A)
ANP  A1401 ( 3.7A)
None
ANP  A1401 ( 4.7A)
ANP  A1401 (-3.3A)
ANP  A1401 (-3.1A)
 0.55A 4o33A-3zlbA:
47.5		 4o33A-3zlbA:
47.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		8 / 12 GLY A 202
GLY A 226
GLY A 227
LEU A 244
PHE A 276
LEU A 297
GLY A 324
VAL A 325
 ANP  A1401 (-3.1A)
ANP  A1401 (-3.3A)
ANP  A1401 (-3.5A)
ANP  A1401 ( 3.7A)
None
ANP  A1401 ( 4.7A)
ANP  A1401 (-3.3A)
ANP  A1401 (-3.1A)
 0.50A 4o3fA-3zlbA:
46.1		 4o3fA-3zlbA:
47.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		4 / 6 LEU A  81
LEU A 113
VAL A 112
PHE A  91
 None
 1.12A 4uswA-3zlbA:
undetectable		 4uswA-3zlbA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_C_QI9C602_0
(CYTOCHROME P450 2D6)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 9 PHE A  22
ASP A  21
VAL A  89
VAL A  77
PHE A  91
 None
GOL  A1404 (-2.7A)
GOL  A1405 (-4.1A)
None
None
 1.47A 4wnvC-3zlbA:
0.0		 4wnvC-3zlbA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 11 ALA A 379
GLU A 382
LEU A 392
LEU A 389
LEU A 178
 None
 1.18A 4zn7B-3zlbA:
undetectable		 4zn7B-3zlbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		6 / 12 GLY A 296
GLY A 334
GLY A 324
THR A 335
ASP A 340
ILE A 304
 ANP  A1401 (-4.2A)
None
ANP  A1401 (-3.3A)
None
None
None
 1.44A 5e9qC-3zlbA:
undetectable		 5e9qC-3zlbA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		6 / 12 GLY A 296
GLY A 334
GLY A 324
THR A 335
ASP A 340
ILE A 304
 ANP  A1401 (-4.2A)
None
ANP  A1401 (-3.3A)
None
None
None
 1.47A 5ec8C-3zlbA:
undetectable		 5ec8C-3zlbA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		3 / 3 TRP A 139
GLU A 121
ASP A 132
 None
 1.07A 5gqbA-3zlbA:
undetectable		 5gqbA-3zlbA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 202
GLY A 324
GLY A 354
SER A 357
LEU A 364
 ANP  A1401 (-3.1A)
ANP  A1401 (-3.3A)
ANP  A1401 (-2.8A)
ANP  A1401 (-2.6A)
None
 1.08A 5gwxA-3zlbA:
4.6		 5gwxA-3zlbA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		6 / 12 GLY A 296
GLY A 334
GLY A 324
THR A 335
ASP A 340
ILE A 304
 ANP  A1401 (-4.2A)
None
ANP  A1401 (-3.3A)
None
None
None
 1.49A 5kqsA-3zlbA:
undetectable		 5kqsA-3zlbA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 9 LEU A 223
GLY A 201
GLY A 353
ILE A 352
VAL A 197
 None
 1.00A 5kr0B-3zlbA:
undetectable		 5kr0B-3zlbA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		6 / 12 GLY A 296
GLY A 334
GLY A 324
THR A 335
ASP A 340
ILE A 304
 ANP  A1401 (-4.2A)
None
ANP  A1401 (-3.3A)
None
None
None
 1.49A 5m5bA-3zlbA:
undetectable		 5m5bA-3zlbA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		6 / 12 GLY A 296
GLY A 334
GLY A 324
THR A 335
ASP A 340
ILE A 304
 ANP  A1401 (-4.2A)
None
ANP  A1401 (-3.3A)
None
None
None
 1.48A 5njvD-3zlbA:
2.1		 5njvD-3zlbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 378
SER A 380
GLU A 382
LEU A 384
ASP A 207
 None
GOL  A1404 ( 4.7A)
None
None
ANP  A1401 ( 4.9A)
 1.44A 5vlmF-3zlbA:
undetectable		 5vlmF-3zlbA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		6 / 12 GLY A 296
GLY A 334
GLY A 324
THR A 335
ASP A 340
ILE A 304
 ANP  A1401 (-4.2A)
None
ANP  A1401 (-3.3A)
None
None
None
 1.49A 5wz2A-3zlbA:
undetectable		 5wz2A-3zlbA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		6 / 12 GLY A 296
GLY A 334
GLY A 324
THR A 335
ASP A 340
ILE A 304
 ANP  A1401 (-4.2A)
None
ANP  A1401 (-3.3A)
None
None
None
 1.50A 5wz2B-3zlbA:
undetectable		 5wz2B-3zlbA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		4 / 6 TYR A 230
GLU A 247
GLY A 227
GLY A 226
 ANP  A1401 ( 4.7A)
None
ANP  A1401 (-3.5A)
ANP  A1401 (-3.3A)
 0.92A 5x7pB-3zlbA:
undetectable		 5x7pB-3zlbA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 12 PRO A 390
ALA A 394
ASN A 149
ALA A 140
ALA A 160
 None
 1.06A 5zw4A-3zlbA:
4.0		 5zw4A-3zlbA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		4 / 7 GLY A 278
ALA A 277
VAL A 325
LEU A 297
 None
None
ANP  A1401 (-3.1A)
ANP  A1401 ( 4.7A)
 0.72A 6dwnB-3zlbA:
undetectable		 6dwnB-3zlbA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		3 / 3 LYS A 271
VAL A 282
ASP A 284
 None
 0.58A 6fgdA-3zlbA:
2.2		 6fgdA-3zlbA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		5 / 10 ALA A  78
LEU A 114
VAL A  89
ILE A  48
ALA A  40
 GOL  A1405 ( 3.9A)
None
GOL  A1405 (-4.1A)
None
None
 1.22A 6h1lA-3zlbA:
undetectable		 6h1lA-3zlbA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3zlb PHOSPHOGLYCERATE
KINASE
(Streptococcus
pneumoniae) 		4 / 6 LEU A  26
PRO A  76
TYR A 120
GLU A 116
 None
 1.03A 6pahA-3zlbA:
undetectable		 6pahA-3zlbA:
22.72