SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 3zle APICAL MEMBRANE
ANTIGEN 1
(Toxoplasma
gondii) 		4 / 7 PHE A 418
PRO A 415
ALA A 426
TRP A 394
 None
 1.28A 1lqtA-3zleA:
undetectable		 1lqtA-3zleA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 3zle APICAL MEMBRANE
ANTIGEN 1
(Toxoplasma
gondii) 		4 / 7 PHE A 418
PRO A 415
ALA A 426
TRP A 394
 None
 1.29A 1lquA-3zleA:
undetectable		 1lquA-3zleA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3zle APICAL MEMBRANE
ANTIGEN 1
(Toxoplasma
gondii) 		5 / 12 ASN A 393
ILE A 115
GLY A 122
ARG A 135
ILE A 123
 None
 1.41A 1q8jA-3zleA:
undetectable		 1q8jA-3zleA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3zle APICAL MEMBRANE
ANTIGEN 1
(Toxoplasma
gondii) 		3 / 3 SER A 121
GLY A 122
ARG A 135
 None
 0.65A 1t9wA-3zleA:
undetectable		 1t9wA-3zleA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3zle APICAL MEMBRANE
ANTIGEN 1
(Toxoplasma
gondii) 		3 / 3 LYS A 344
LYS A 315
VAL A 425
 None
 1.04A 3brfA-3zleA:
undetectable		 3brfA-3zleA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 3zle APICAL MEMBRANE
ANTIGEN 1
(Toxoplasma
gondii) 		3 / 3 ALA A 224
VAL A 225
GLN A 183
 None
 0.75A 3of4B-3zleA:
undetectable		 3of4B-3zleA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3zle APICAL MEMBRANE
ANTIGEN 1
(Toxoplasma
gondii) 		5 / 12 ALA A 358
PHE A 352
ALA A 429
ASP A 360
VAL A 125
 None
 1.11A 4df3B-3zleA:
undetectable		 4df3B-3zleA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3zle APICAL MEMBRANE
ANTIGEN 1
(Toxoplasma
gondii) 		5 / 10 ASP A 360
SER A 387
VAL A 143
GLY A 431
VAL A 351
 None
 1.29A 6hu9L-3zleA:
undetectable
6hu9P-3zleA:
undetectable
6hu9T-3zleA:
undetectable		 6hu9L-3zleA:
21.55
6hu9P-3zleA:
17.47
6hu9T-3zleA:
11.37