SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zm8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_A_CYZA330_1
(GLUTAMINE RECEPTOR 2)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 PRO A 292
LEU A 294
LEU A 142
ILE A 223
SER A 156
 None
 1.20A 1lbcA-3zm8A:
undetectable
1lbcC-3zm8A:
undetectable		 1lbcA-3zm8A:
19.75
1lbcC-3zm8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 ILE A 223
SER A 156
PRO A 292
LEU A 294
LEU A 142
 None
 1.25A 1lbcA-3zm8A:
undetectable
1lbcC-3zm8A:
undetectable		 1lbcA-3zm8A:
19.75
1lbcC-3zm8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 ILE A 122
GLU A  15
VAL A  24
LEU A  19
PHE A  49
 None
CA  A1450 (-2.4A)
None
None
None
 1.50A 1p5zB-3zm8A:
undetectable		 1p5zB-3zm8A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 ARG A 180
ILE A 179
ASP A 415
GLY A 414
 None
 0.73A 1rtsB-3zm8A:
undetectable		 1rtsB-3zm8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		3 / 3 LEU A 103
LEU A  58
SER A 130
 None
 0.55A 1tlmA-3zm8A:
undetectable		 1tlmA-3zm8A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 5 ALA A 359
TRP A 407
LEU A 408
ALA A 389
 None
 1.23A 2jstA-3zm8A:
undetectable
2jstB-3zm8A:
undetectable		 2jstA-3zm8A:
9.64
2jstB-3zm8A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 ILE A 122
GLU A  15
VAL A  24
LEU A  19
PHE A  49
 None
CA  A1450 (-2.4A)
None
None
None
 1.43A 2ziaB-3zm8A:
undetectable		 2ziaB-3zm8A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 LEU A 271
ILE A 322
ASP A 275
SER A 198
PHE A 255
 None
 1.26A 3axtA-3zm8A:
undetectable		 3axtA-3zm8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 11 PRO A 292
LEU A 294
LEU A 142
ILE A 223
SER A 156
 None
 1.23A 3h6tA-3zm8A:
undetectable
3h6tC-3zm8A:
undetectable		 3h6tA-3zm8A:
19.75
3h6tC-3zm8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 11 ILE A 223
SER A 156
PRO A 292
LEU A 294
LEU A 142
 None
 1.23A 3h6tA-3zm8A:
undetectable
3h6tC-3zm8A:
undetectable		 3h6tA-3zm8A:
19.75
3h6tC-3zm8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 5 ILE A 273
TRP A 295
TRP A 308
TRP A 307
 None
 1.48A 3wemA-3zm8A:
0.4		 3wemA-3zm8A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 ALA A 214
LEU A 283
LEU A 286
ARG A 448
LEU A 227
 None
 1.11A 4dm8B-3zm8A:
undetectable		 4dm8B-3zm8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 6 SER A 198
ASP A 275
ARG A 274
GLU A 203
 None
 1.25A 4eysA-3zm8A:
undetectable		 4eysA-3zm8A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 5 ALA A 393
ILE A 432
LEU A 396
ASN A 424
 None
 0.89A 4g19A-3zm8A:
undetectable		 4g19A-3zm8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		3 / 3 ASP A 193
TRP A 320
SER A 198
 None
 0.94A 4lrhA-3zm8A:
undetectable		 4lrhA-3zm8A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		3 / 3 GLU A 300
ALA A 301
PHE A 306
 TLA  A1452 (-2.8A)
None
None
 0.53A 4v1fA-3zm8A:
undetectable		 4v1fA-3zm8A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		3 / 3 GLU A 300
ALA A 301
PHE A 306
 TLA  A1452 (-2.8A)
None
None
 0.52A 4v1fC-3zm8A:
undetectable		 4v1fC-3zm8A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 TYR A  65
ILE A  63
ILE A 122
THR A  74
 None
 0.92A 5murB-3zm8A:
undetectable		 5murB-3zm8A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 SER A 225
LEU A 189
ALA A 411
ILE A 179
 None
 0.97A 5te8A-3zm8A:
undetectable		 5te8A-3zm8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 10 VAL A 438
PHE A 410
LEU A 429
ASN A 424
ILE A 179
 None
 1.37A 6d9hR-3zm8A:
undetectable		 6d9hR-3zm8A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 10 VAL A 438
PHE A 410
LEU A 429
ILE A 179
THR A 183
 None
 1.38A 6d9hR-3zm8A:
undetectable		 6d9hR-3zm8A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		5 / 12 LEU A 189
ILE A 223
GLY A 222
ASP A 442
ILE A 167
 None
 0.95A 6emuA-3zm8A:
undetectable		 6emuA-3zm8A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 8 GLU A 375
VAL A 361
ARG A 133
GLN A 404
 None
 1.14A 6fbvD-3zm8A:
undetectable		 6fbvD-3zm8A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE
(Podospora
anserina) 		4 / 7 SER A 225
ALA A 411
ILE A 179
ALA A 176
 None
 0.94A 6ma7A-3zm8A:
undetectable		 6ma7A-3zm8A:
10.27