SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zn6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_A_H4BA700_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 VAL A 102
ARG A 114
PHE A 166
GLU A 179
 None
 1.34A 1d1vA-3zn6A:
undetectable
1d1vB-3zn6A:
undetectable		 1d1vA-3zn6A:
20.31
1d1vB-3zn6A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 VAL A 102
ARG A 114
PHE A 166
GLU A 179
 None
 1.38A 1nseA-3zn6A:
undetectable
1nseB-3zn6A:
undetectable		 1nseA-3zn6A:
20.31
1nseB-3zn6A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 PHE A 166
GLU A 179
VAL A 102
ARG A 114
 None
 1.33A 1rs8A-3zn6A:
undetectable
1rs8B-3zn6A:
undetectable		 1rs8A-3zn6A:
21.41
1rs8B-3zn6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 VAL A 102
ARG A 114
PHE A 166
GLU A 179
 None
 1.32A 1rs9A-3zn6A:
undetectable
1rs9B-3zn6A:
undetectable		 1rs9A-3zn6A:
21.41
1rs9B-3zn6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 3zn6 VP17
(Thermus
virus
P23-77) 		3 / 3 GLN A 263
ILE A 262
TYR A 261
 None
 0.76A 1vifA-3zn6A:
undetectable		 1vifA-3zn6A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3zn6 VP17
(Thermus
virus
P23-77) 		5 / 11 TYR A 135
THR A 124
GLY A 127
ALA A 128
VAL A 183
 None
 1.41A 2cojA-3zn6A:
undetectable
2cojB-3zn6A:
undetectable		 2cojA-3zn6A:
21.78
2cojB-3zn6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 VAL A 102
ARG A 114
PHE A 166
GLU A 179
 None
 1.37A 3jwzA-3zn6A:
undetectable
3jwzB-3zn6A:
undetectable		 3jwzA-3zn6A:
20.31
3jwzB-3zn6A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 VAL A 102
ARG A 114
PHE A 166
GLU A 179
 None
 1.36A 3n5rA-3zn6A:
undetectable
3n5rB-3zn6A:
undetectable		 3n5rA-3zn6A:
20.31
3n5rB-3zn6A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 PHE A 166
GLU A 179
VAL A 102
ARG A 114
 None
 1.34A 3n5rA-3zn6A:
undetectable
3n5rB-3zn6A:
undetectable		 3n5rA-3zn6A:
20.31
3n5rB-3zn6A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3zn6 VP17
(Thermus
virus
P23-77) 		5 / 6 THR A 173
GLY A 105
ARG A 257
ILE A 178
LEU A 108
 None
 1.45A 4acbC-3zn6A:
undetectable		 4acbC-3zn6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 3zn6 VP17
VP16
(Thermus
virus
P23-77;
Thermus
virus
P23-77) 		3 / 3 GLN B  68
ASP B 100
GLN A 126
 None
 0.86A 4aztA-3zn6B:
undetectable		 4aztA-3zn6B:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU1_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 PHE A 166
GLU A 179
VAL A 102
ARG A 114
 None
 1.38A 4cu1A-3zn6A:
undetectable
4cu1B-3zn6A:
undetectable		 4cu1A-3zn6A:
20.35
4cu1B-3zn6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 VAL A 102
ARG A 114
PHE A 166
GLU A 179
 None
 1.38A 4cwwA-3zn6A:
undetectable
4cwwB-3zn6A:
undetectable		 4cwwA-3zn6A:
20.35
4cwwB-3zn6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D34_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 PHE A 166
GLU A 179
VAL A 102
ARG A 114
 None
 1.36A 4d34A-3zn6A:
undetectable
4d34B-3zn6A:
undetectable		 4d34A-3zn6A:
20.35
4d34B-3zn6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 VAL A 102
ARG A 114
PHE A 166
GLU A 179
 None
 1.35A 4d36A-3zn6A:
undetectable
4d36B-3zn6A:
undetectable		 4d36A-3zn6A:
20.35
4d36B-3zn6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 PHE A 166
GLU A 179
VAL A 102
ARG A 114
 None
 1.36A 4d36A-3zn6A:
undetectable
4d36B-3zn6A:
undetectable		 4d36A-3zn6A:
20.35
4d36B-3zn6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 VAL A 102
ARG A 114
PHE A 166
GLU A 179
 None
 1.38A 4d39A-3zn6A:
undetectable
4d39B-3zn6A:
undetectable		 4d39A-3zn6A:
20.35
4d39B-3zn6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 VAL A 102
ARG A 114
PHE A 166
GLU A 179
 None
 1.39A 4k5iA-3zn6A:
undetectable
4k5iB-3zn6A:
undetectable		 4k5iA-3zn6A:
20.35
4k5iB-3zn6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 VAL A 102
ARG A 114
PHE A 166
GLU A 179
 None
 1.38A 4kcpA-3zn6A:
undetectable
4kcpB-3zn6A:
undetectable		 4kcpA-3zn6A:
20.35
4kcpB-3zn6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 VAL A 102
ARG A 114
PHE A 166
GLU A 179
 None
 1.38A 4kcqA-3zn6A:
undetectable
4kcqB-3zn6A:
undetectable		 4kcqA-3zn6A:
20.35
4kcqB-3zn6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 VAL A 102
ARG A 114
PHE A 166
GLU A 179
 None
 1.39A 4kcsA-3zn6A:
undetectable
4kcsB-3zn6A:
undetectable		 4kcsA-3zn6A:
20.35
4kcsB-3zn6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 VAL A 102
ARG A 114
PHE A 166
GLU A 179
 None
 1.36A 4uh9A-3zn6A:
undetectable
4uh9B-3zn6A:
undetectable		 4uh9A-3zn6A:
20.35
4uh9B-3zn6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 VAL A 102
ARG A 114
PHE A 166
GLU A 179
 None
 1.39A 4upqA-3zn6A:
undetectable
4upqB-3zn6A:
undetectable		 4upqA-3zn6A:
20.35
4upqB-3zn6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 VAL A 102
ARG A 114
PHE A 166
GLU A 179
 None
 1.35A 5adkA-3zn6A:
undetectable
5adkB-3zn6A:
undetectable		 5adkA-3zn6A:
20.35
5adkB-3zn6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 VAL A 102
ARG A 114
PHE A 166
GLU A 179
 None
 1.38A 5fj2A-3zn6A:
undetectable
5fj2B-3zn6A:
undetectable		 5fj2A-3zn6A:
20.35
5fj2B-3zn6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 3zn6 VP16
(Thermus
virus
P23-77) 		4 / 6 TYR B  95
TYR B  99
ASP B  74
TYR B  62
 None
 1.47A 5ov9A-3zn6B:
undetectable		 5ov9A-3zn6B:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 7 PHE A 166
GLU A 179
VAL A 102
ARG A 114
 None
 1.33A 5uo9A-3zn6A:
undetectable
5uo9B-3zn6A:
undetectable		 5uo9A-3zn6A:
20.18
5uo9B-3zn6A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 PHE A 166
GLU A 179
VAL A 102
ARG A 114
 None
 1.37A 5vv6A-3zn6A:
undetectable
5vv6B-3zn6A:
undetectable		 5vv6A-3zn6A:
20.35
5vv6B-3zn6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 PHE A 166
GLU A 179
VAL A 102
ARG A 114
 None
 1.37A 5vv8A-3zn6A:
undetectable
5vv8B-3zn6A:
undetectable		 5vv8A-3zn6A:
20.35
5vv8B-3zn6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 PHE A 166
GLU A 179
VAL A 102
ARG A 114
 None
 1.35A 5vvbC-3zn6A:
undetectable
5vvbD-3zn6A:
undetectable		 5vvbC-3zn6A:
20.18
5vvbD-3zn6A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zn6 VP17
(Thermus
virus
P23-77) 		4 / 6 PHE A 166
GLU A 179
VAL A 102
ARG A 114
 None
 1.38A 6cifA-3zn6A:
undetectable
6cifB-3zn6A:
undetectable		 6cifA-3zn6A:
17.24
6cifB-3zn6A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3zn6 VP16
(Thermus
virus
P23-77) 		3 / 3 ASN B  53
PRO B 128
GLN B 126
 None
 0.86A 6jnhA-3zn6B:
undetectable		 6jnhA-3zn6B:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3zn6 VP16
(Thermus
virus
P23-77) 		3 / 3 ASN B  53
PRO B 128
GLN B 126
 None
 0.88A 6jogA-3zn6B:
undetectable		 6jogA-3zn6B:
22.95