SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zo9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 5 LEU A 377
LEU A 338
SER A 397
LEU A 398
 None
 1.06A 1a4lC-3zo9A:
6.0		 1a4lC-3zo9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 6 TYR A  50
GLY A  62
ASP A  59
GLY A  56
 None
None
MG  A1592 (-3.1A)
None
 0.99A 1eswA-3zo9A:
16.3		 1eswA-3zo9A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLN A 142
HIS A 146
ARG A 186
 None
 0.89A 1zlqA-3zo9A:
undetectable		 1zlqA-3zo9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ILE A 224
ILE A 126
PHE A 111
ALA A 118
LEU A 115
 None
 1.18A 2m9qA-3zo9A:
undetectable		 2m9qA-3zo9A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_2
(MINERALOCORTICOID
RECEPTOR)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 4 LEU A 473
TRP A  72
LEU A  73
MET A 428
 None
 1.41A 2oaxE-3zo9A:
0.0		 2oaxE-3zo9A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LEU A 338
MET A 303
MET A 296
 None
 0.80A 2vavF-3zo9A:
1.6		 2vavF-3zo9A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A 259
LEU A 229
LEU A 216
LEU A 269
ARG A 267
 None
 1.12A 2xn7A-3zo9A:
undetectable
2xn7B-3zo9A:
undetectable		 2xn7A-3zo9A:
18.87
2xn7B-3zo9A:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ALA A 489
GLY A 400
LYS A  37
HIS A  38
 None
 1.44A 2yldA-3zo9A:
undetectable		 2yldA-3zo9A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KD5_E_PPFE914_1
(DNA POLYMERASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ASP A 128
LEU A 344
ARG A 339
ASP A 230
 None
None
CL  A1587 (-4.5A)
None
 1.34A 3kd5E-3zo9A:
0.8		 3kd5E-3zo9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O0M_A_ACTA146_0
(HIT FAMILY PROTEIN)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ASP A 342
GLU A 343
GLU A 272
ARG A 228
 CL  A1587 ( 4.4A)
CL  A1587 (-4.9A)
None
CL  A1587 (-3.0A)
 1.22A 3o0mA-3zo9A:
1.0		 3o0mA-3zo9A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A  63
PHE A  49
TYR A  42
LEU A  67
ILE A  70
 None
 1.28A 3o94A-3zo9A:
undetectable		 3o94A-3zo9A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A  63
PHE A  49
TYR A  42
LEU A  67
ILE A  70
 None
 1.33A 3o94B-3zo9A:
undetectable		 3o94B-3zo9A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A  63
PHE A  49
TYR A  42
LEU A  67
ILE A  70
 None
 1.29A 3o94C-3zo9A:
1.4		 3o94C-3zo9A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A  63
PHE A  49
TYR A  42
LEU A  67
ILE A  70
 None
 1.28A 3o94D-3zo9A:
undetectable		 3o94D-3zo9A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		3 / 3 HIS A 295
SER A 401
ASN A  34
 None
 0.85A 3s8pB-3zo9A:
undetectable		 3s8pB-3zo9A:
18.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOA_A_ACRA1587_1
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		6 / 10 TRP A 476
ASN A 479
MET A 480
THR A 555
PHE A 577
TYR A 578
 None
 0.83A 3zoaA-3zo9A:
64.5		 3zoaA-3zo9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOA_A_ACRA1587_1
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		9 / 10 TRP A 476
MET A 480
GLU A 553
MET A 554
THR A 555
TYR A 557
PHE A 577
TYR A 578
TRP A 579
 None
 0.24A 3zoaA-3zo9A:
64.5		 3zoaA-3zo9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 534
PHE A 535
PRO A 536
 None
 0.24A 3zoaB-3zo9A:
62.6		 3zoaB-3zo9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ALA A 489
GLY A 400
LYS A  37
HIS A  38
 None
 1.48A 3zwiA-3zo9A:
undetectable		 3zwiA-3zo9A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ALA A 465
ILE A 410
LEU A 474
ASN A 462
 None
 1.19A 4g19A-3zo9A:
undetectable		 4g19A-3zo9A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A 318
GLN A 324
ALA A 323
LEU A 322
LEU A 302
 None
 1.15A 4g1bB-3zo9A:
undetectable		 4g1bB-3zo9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		5 / 10 PHE A 438
ARG A 376
TYR A 405
GLY A 407
ARG A  47
 None
None
None
None
CL  A1590 (-4.3A)
 1.48A 4kouA-3zo9A:
undetectable		 4kouA-3zo9A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASP A 351
ASN A 274
ALA A 273
TYR A 283
 None
 1.19A 4mdaA-3zo9A:
0.8		 4mdaA-3zo9A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASN A 242
GLU A 237
GLU A 244
TYR A 190
 None
CA  A1589 (-2.9A)
None
None
 1.21A 4mj8A-3zo9A:
undetectable
4mj8C-3zo9A:
undetectable		 4mj8A-3zo9A:
16.57
4mj8C-3zo9A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLN A 198
HIS A 197
ARG A  89
 None
 1.14A 4qyqA-3zo9A:
undetectable		 4qyqA-3zo9A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLN A 198
HIS A 197
ARG A  89
 None
 1.11A 4qyqB-3zo9A:
undetectable		 4qyqB-3zo9A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ILE A 318
LEU A 506
ARG A 311
LEU A 390
 None
 0.95A 5b1bA-3zo9A:
undetectable
5b1bJ-3zo9A:
undetectable		 5b1bA-3zo9A:
21.46
5b1bJ-3zo9A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		3 / 3 HIS A 295
SER A 401
ASN A  34
 None
 0.79A 5cprB-3zo9A:
undetectable		 5cprB-3zo9A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A 154
ARG A 238
ARG A 164
 None
 0.96A 5eajB-3zo9A:
undetectable		 5eajB-3zo9A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A 115
LEU A  67
PHE A 111
LEU A  80
 None
 0.86A 5gs4A-3zo9A:
undetectable		 5gs4A-3zo9A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 5 LEU A 115
LEU A  67
PHE A 111
LEU A  80
 None
 0.86A 5gtrA-3zo9A:
undetectable		 5gtrA-3zo9A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 6 TYR A 405
ASP A 422
ILE A 373
TYR A  93
 None
 1.26A 5igyA-3zo9A:
2.8		 5igyA-3zo9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ILE A 318
LEU A 506
ARG A 311
LEU A 390
 None
 1.00A 5iy5A-3zo9A:
undetectable
5iy5J-3zo9A:
undetectable		 5iy5A-3zo9A:
21.46
5iy5J-3zo9A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLY A 106
THR A 107
GLY A 419
LEU A  45
 None
CL  A1591 ( 4.7A)
None
CL  A1590 (-4.1A)
 0.91A 5jlcA-3zo9A:
undetectable		 5jlcA-3zo9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 164
GLU A 239
PRO A 166
TRP A 180
 None
 1.14A 5kf8A-3zo9A:
0.9		 5kf8A-3zo9A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 335
ILE A 336
PHE A 337
VAL A 280
LEU A 338
 None
None
CL  A1587 ( 4.9A)
None
None
 1.04A 5nz0A-3zo9A:
undetectable		 5nz0A-3zo9A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TRP A 334
GLY A 335
ILE A 336
PHE A 337
VAL A 280
 None
None
None
CL  A1587 ( 4.9A)
None
 0.97A 5nz0A-3zo9A:
undetectable		 5nz0A-3zo9A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ARG A 376
PHE A 391
LEU A 380
LEU A 473
 None
 1.36A 5veuH-3zo9A:
undetectable		 5veuH-3zo9A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ILE A 318
LEU A 506
ARG A 311
LEU A 390
 None
 0.94A 5xdqA-3zo9A:
undetectable
5xdqJ-3zo9A:
undetectable		 5xdqA-3zo9A:
21.46
5xdqJ-3zo9A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		3 / 3 MET A 348
ASP A 355
ARG A 312
 None
 0.92A 5z6jA-3zo9A:
undetectable		 5z6jA-3zo9A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		3 / 3 MET A 348
ASP A 355
ARG A 312
 None
 1.17A 5z6kA-3zo9A:
undetectable		 5z6kA-3zo9A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ILE A 318
LEU A 506
ARG A 311
LEU A 390
 None
 0.93A 5zcqN-3zo9A:
undetectable
5zcqW-3zo9A:
undetectable		 5zcqN-3zo9A:
21.46
5zcqW-3zo9A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 7 THR A 345
ASP A 342
LEU A 344
TYR A 234
 None
CL  A1587 ( 4.4A)
None
None
 0.98A 5zsfA-3zo9A:
undetectable
5zsfB-3zo9A:
undetectable		 5zsfA-3zo9A:
8.58
5zsfB-3zo9A:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A  63
LEU A 114
ALA A 117
ALA A 118
 None
 0.77A 6a7jA-3zo9A:
undetectable		 6a7jA-3zo9A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 6 VAL A 185
ASN A 147
PRO A 148
GLU A 143
 None
 1.16A 6h7uA-3zo9A:
undetectable		 6h7uA-3zo9A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 193
HIS A 192
GLU A 237
GLU A 244
 None
None
CA  A1589 (-2.9A)
None
 1.17A 6mn4A-3zo9A:
undetectable		 6mn4A-3zo9A:
19.36