SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zok'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		4 / 6 ALA A 314
SER A 302
TRP A 213
LEU A 196
 None
 1.23A 1gahA-3zokA:
undetectable		 1gahA-3zokA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		5 / 12 TYR A 172
ARG A 134
GLY A 135
ALA A 128
PHE A 113
 None
 1.03A 1gseA-3zokA:
undetectable		 1gseA-3zokA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		5 / 12 TYR A 172
ARG A 134
GLY A 135
ALA A 128
PHE A 113
 None
 1.10A 1gseB-3zokA:
undetectable		 1gseB-3zokA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		4 / 7 THR A 144
LEU A 192
GLY A 195
LEU A 277
 NAD  A1381 (-3.5A)
None
None
None
 0.98A 1gtiD-3zokA:
undetectable		 1gtiD-3zokA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		5 / 12 ALA A 289
LEU A 204
LEU A 311
THR A 262
LEU A 259
 PO4  A1380 (-3.2A)
None
None
PO4  A1380 (-3.4A)
PO4  A1380 (-4.5A)
 1.39A 1jipA-3zokA:
undetectable		 1jipA-3zokA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		5 / 10 GLU A  87
VAL A 120
GLY A 119
ASN A 166
HIS A 261
 NAD  A1381 (-3.2A)
NAD  A1381 (-3.8A)
NAD  A1381 (-3.1A)
PO4  A1379 ( 3.6A)
PO4  A1379 ( 4.3A)
 1.22A 1pwyE-3zokA:
undetectable		 1pwyE-3zokA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		5 / 10 GLU A  87
VAL A 120
GLY A 119
ASN A 166
HIS A 261
 NAD  A1381 (-3.2A)
NAD  A1381 (-3.8A)
NAD  A1381 (-3.1A)
PO4  A1379 ( 3.6A)
PO4  A1379 ( 4.3A)
 1.15A 1v3qE-3zokA:
undetectable		 1v3qE-3zokA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		5 / 12 ALA A 283
VAL A 200
PHE A 211
LEU A 353
ILE A 205
 None
 1.06A 1xozA-3zokA:
undetectable		 1xozA-3zokA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		4 / 7 LYS A  64
ASN A  71
PRO A  37
ALA A  68
 None
 1.34A 2ejgA-3zokA:
undetectable		 2ejgA-3zokA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		3 / 3 SER A 194
THR A 183
GLN A 148
 None
NAD  A1381 (-4.9A)
None
 0.83A 2fk8A-3zokA:
undetectable		 2fk8A-3zokA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		5 / 11 ALA A 283
VAL A 200
PHE A 211
LEU A 353
ILE A 205
 None
 0.93A 2h42A-3zokA:
undetectable		 2h42A-3zokA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		4 / 8 SER A 293
LEU A 349
LEU A 259
ASP A 291
 None
None
PO4  A1380 (-4.5A)
None
 1.08A 2j2pA-3zokA:
undetectable
2j2pB-3zokA:
undetectable		 2j2pA-3zokA:
20.64
2j2pB-3zokA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		4 / 7 GLY A 158
GLY A 154
GLN A 140
PHE A 138
 None
 0.91A 2qwxA-3zokA:
3.6
2qwxB-3zokA:
3.3		 2qwxA-3zokA:
20.37
2qwxB-3zokA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		4 / 7 GLY A 169
GLY A 154
GLN A 140
PHE A 138
 None
 0.91A 2qwxA-3zokA:
3.6
2qwxB-3zokA:
3.3		 2qwxA-3zokA:
20.37
2qwxB-3zokA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		5 / 12 GLY A 118
GLU A 268
VAL A 282
ASP A 150
ASP A 123
 NAD  A1381 (-3.3A)
None
None
NAD  A1381 ( 3.2A)
NAD  A1381 (-3.0A)
 1.12A 2vqyA-3zokA:
undetectable		 2vqyA-3zokA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		5 / 9 ARG A 190
ALA A 197
GLY A 264
ILE A 267
LEU A 277
 None
 1.11A 3u7sB-3zokA:
undetectable		 3u7sB-3zokA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		4 / 6 SER A  31
ASP A 180
THR A  14
THR A 183
 None
None
None
NAD  A1381 (-4.9A)
 1.04A 4acbC-3zokA:
5.3		 4acbC-3zokA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		3 / 4 SER A 236
GLY A 279
GLU A  87
 None
None
NAD  A1381 (-3.2A)
 0.57A 4juoA-3zokA:
undetectable
4juoC-3zokA:
undetectable		 4juoA-3zokA:
23.18
4juoC-3zokA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJJ_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		5 / 12 GLU A 250
ASP A 336
THR A 262
GLU A 198
LYS A 156
 None
None
PO4  A1380 (-3.4A)
PO4  A1379 ( 4.8A)
GLY  A1384 (-2.8A)
 1.46A 4njjA-3zokA:
0.1		 4njjA-3zokA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJJ_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		5 / 12 GLU A 250
ASP A 336
THR A 262
GLU A 198
LYS A 156
 None
None
PO4  A1380 (-3.4A)
PO4  A1379 ( 4.8A)
GLY  A1384 (-2.8A)
 1.45A 4njjB-3zokA:
2.4		 4njjB-3zokA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		5 / 12 LEU A 184
THR A  53
LEU A 116
ILE A  27
TYR A  61
 None
None
None
None
NAD  A1381 (-4.5A)
 1.02A 5dlvA-3zokA:
undetectable		 5dlvA-3zokA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		5 / 12 LEU A 187
LEU A 229
ALA A 193
SER A 194
LEU A 196
 NAD  A1381 (-4.5A)
None
None
None
None
 0.99A 5jvzA-3zokA:
undetectable		 5jvzA-3zokA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		5 / 12 LEU A 187
LEU A 229
ALA A 193
SER A 194
LEU A 196
 NAD  A1381 (-4.5A)
None
None
None
None
 1.00A 5jvzB-3zokA:
undetectable		 5jvzB-3zokA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		6 / 11 GLY A 126
GLY A 122
LEU A  50
SER A  80
THR A  53
VAL A  98
 None
 1.42A 5twjD-3zokA:
undetectable		 5twjD-3zokA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		5 / 9 LEU A 349
ARG A 295
ALA A 289
VAL A 287
ASP A 291
 None
None
PO4  A1380 (-3.2A)
None
None
 1.27A 6c2mB-3zokA:
undetectable		 6c2mB-3zokA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zok 3-DEHYDROQUINATE
SYNTHASE
(Actinidia
chinensis) 		4 / 8 ILE A  27
VAL A 145
MET A 146
ASP A 123
 None
None
NAD  A1381 (-4.0A)
NAD  A1381 (-3.0A)
 1.01A 6hu9a-3zokA:
undetectable
6hu9e-3zokA:
undetectable		 6hu9a-3zokA:
20.55
6hu9e-3zokA:
18.24