SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zpc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		4 / 7 LEU A 274
LEU A 295
ILE A 198
MET A 251
 None
 1.07A 1n13I-3zpcA:
undetectable
1n13L-3zpcA:
undetectable		 1n13I-3zpcA:
8.75
1n13L-3zpcA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		4 / 4 ASP A 342
LEU A 354
LEU A 352
LEU A 341
 None
 1.34A 1u18A-3zpcA:
undetectable		 1u18A-3zpcA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		3 / 3 ARG A  61
GLN A  52
PRO A  53
 None
 0.91A 2qhfA-3zpcA:
undetectable		 2qhfA-3zpcA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		4 / 7 ILE A 198
MET A 251
LEU A 274
LEU A 295
 None
 1.05A 2qqcB-3zpcA:
undetectable
2qqcC-3zpcA:
undetectable		 2qqcB-3zpcA:
14.05
2qqcC-3zpcA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		4 / 7 LEU A 274
LEU A 295
ILE A 198
MET A 251
 None
 1.07A 2qqcA-3zpcA:
undetectable
2qqcF-3zpcA:
undetectable		 2qqcA-3zpcA:
9.52
2qqcF-3zpcA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		4 / 7 LEU A 274
LEU A 295
ILE A 198
MET A 251
 None
 1.05A 2qqcI-3zpcA:
undetectable
2qqcL-3zpcA:
undetectable		 2qqcI-3zpcA:
9.52
2qqcL-3zpcA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		4 / 7 LEU A 274
LEU A 295
ILE A 198
MET A 251
 None
 1.06A 2qqdA-3zpcA:
undetectable
2qqdE-3zpcA:
1.7		 2qqdA-3zpcA:
10.29
2qqdE-3zpcA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		4 / 5 VAL A 227
VAL A 250
THR A 277
THR A 196
 None
 1.27A 3bjwG-3zpcA:
undetectable		 3bjwG-3zpcA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		5 / 11 LEU A 242
ASP A 204
GLY A 197
VAL A 248
ILE A 241
 None
 0.88A 3oxxB-3zpcA:
undetectable		 3oxxB-3zpcA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		5 / 11 LEU A 242
ASP A 204
GLY A 197
VAL A 248
ILE A 241
 None
 0.96A 3oxxD-3zpcA:
undetectable		 3oxxD-3zpcA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		5 / 11 LEU A 266
TYR A 285
VAL A 287
GLY A 192
ALA A 193
 None
 1.20A 3pghB-3zpcA:
undetectable		 3pghB-3zpcA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		5 / 12 ASP A 162
ARG A 322
ALA A 321
ALA A 168
SER A 169
 None
 0.87A 3sudA-3zpcA:
undetectable		 3sudA-3zpcA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		5 / 9 PHE A 299
LEU A 275
VAL A 287
LEU A 229
ILE A 195
 None
 1.14A 3tbgD-3zpcA:
undetectable		 3tbgD-3zpcA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		4 / 7 ILE A 241
ILE A 198
GLU A 257
VAL A 263
 None
 0.83A 3ua5B-3zpcA:
undetectable		 3ua5B-3zpcA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		4 / 5 HIS A  81
GLY A  83
TYR A  82
GLU A  90
 PO4  A1361 (-4.1A)
PO4  A1361 (-3.4A)
None
None
 1.44A 4ae1B-3zpcA:
undetectable		 4ae1B-3zpcA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		3 / 3 LEU A 229
MET A 251
ASP A 286
 None
None
ACT  A1359 (-3.2A)
 0.82A 4j7xB-3zpcA:
undetectable		 4j7xB-3zpcA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		3 / 3 GLY A 252
PRO A 253
GLN A 265
 None
 0.49A 4oltB-3zpcA:
undetectable		 4oltB-3zpcA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		3 / 3 GLY A 252
PRO A 253
GLN A 265
 None
 0.46A 4qwpB-3zpcA:
undetectable		 4qwpB-3zpcA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		5 / 10 VAL A 248
THR A 196
VAL A 250
LEU A 208
LEU A 235
 None
 1.02A 4yb6A-3zpcA:
2.8
4yb6E-3zpcA:
2.7		 4yb6A-3zpcA:
23.04
4yb6E-3zpcA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		5 / 10 VAL A 248
THR A 196
VAL A 250
LEU A 208
LEU A 235
 None
 1.03A 4yb6B-3zpcA:
3.0
4yb6C-3zpcA:
2.8		 4yb6B-3zpcA:
23.04
4yb6C-3zpcA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		5 / 10 LEU A 208
LEU A 235
VAL A 248
THR A 196
VAL A 250
 None
 1.02A 4yb6B-3zpcA:
3.0
4yb6F-3zpcA:
undetectable		 4yb6B-3zpcA:
23.04
4yb6F-3zpcA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		3 / 3 TRP A 187
ARG A 154
LEU A 341
 None
ACT  A1359 (-3.5A)
None
 1.00A 5dbyA-3zpcA:
undetectable		 5dbyA-3zpcA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		5 / 12 GLY A  32
VAL A  74
ALA A  72
LEU A  41
ALA A  91
 None
 0.95A 5xv7A-3zpcA:
undetectable		 5xv7A-3zpcA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Acinetobacter
baumannii) 		5 / 12 ASP A 162
ARG A 322
ALA A 321
ALA A 168
SER A 169
 None
 1.02A 6c2mC-3zpcA:
undetectable		 6c2mC-3zpcA:
13.70