SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zph'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		3 / 4 VAL A 173
TRP A 215
TRP A 243
 None
 1.40A 1gmkC-3zphA:
undetectable
1gmkD-3zphA:
undetectable		 1gmkC-3zphA:
34.78
1gmkD-3zphA:
34.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		4 / 8 LEU A  11
VAL A 263
TYR A  13
GLU A  72
 None
 1.01A 1jlfA-3zphA:
3.0
1jlfB-3zphA:
3.0		 1jlfA-3zphA:
17.26
1jlfB-3zphA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		4 / 6 GLU A 145
ARG A 198
ASP A 147
LEU A 148
 None
 1.00A 1mt1B-3zphA:
undetectable
1mt1C-3zphA:
undetectable		 1mt1B-3zphA:
18.84
1mt1C-3zphA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		4 / 8 MET A  68
SER A 269
ILE A  29
ASN A 271
 None
 0.98A 1pnlA-3zphA:
undetectable
1pnlB-3zphA:
undetectable		 1pnlA-3zphA:
24.34
1pnlB-3zphA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		5 / 12 PHE A 221
PHE A 183
LEU A 182
PHE A 249
VAL A 186
 None
 1.20A 1q23B-3zphA:
undetectable		 1q23B-3zphA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		5 / 12 PHE A 221
PHE A 183
LEU A 182
PHE A 249
VAL A 186
 None
 1.20A 1q23C-3zphA:
undetectable		 1q23C-3zphA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		5 / 11 PHE A 221
PHE A 183
LEU A 182
PHE A 249
VAL A 186
 None
 1.21A 1q23I-3zphA:
undetectable		 1q23I-3zphA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		5 / 11 PHE A 221
PHE A 183
LEU A 182
PHE A 249
VAL A 186
 None
 1.18A 1q23L-3zphA:
undetectable		 1q23L-3zphA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		5 / 12 LEU A 217
ASP A 214
GLY A 168
VAL A 204
ALA A 203
 None
 1.16A 2kceA-3zphA:
undetectable		 2kceA-3zphA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		5 / 12 LEU A 217
ASP A 214
GLY A 168
VAL A 204
ALA A 203
 None
 1.08A 2kceB-3zphA:
undetectable		 2kceB-3zphA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		4 / 7 PHE A 249
MET A 165
LEU A 190
ILE A 189
 None
 0.87A 3rfmA-3zphA:
undetectable		 3rfmA-3zphA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		5 / 12 SER A  37
TYR A  48
PHE A  41
PHE A 135
PHE A  50
 None
None
None
GOL  A 301 ( 4.9A)
None
 1.33A 3u9fB-3zphA:
undetectable
3u9fC-3zphA:
undetectable		 3u9fB-3zphA:
22.18
3u9fC-3zphA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_C_CLMC221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		5 / 11 PHE A  50
SER A  37
TYR A  48
PHE A  41
PHE A 135
 None
None
None
None
GOL  A 301 ( 4.9A)
 1.32A 3u9fA-3zphA:
undetectable
3u9fC-3zphA:
undetectable		 3u9fA-3zphA:
22.18
3u9fC-3zphA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_F_CLMF221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		5 / 10 PHE A  50
SER A  37
TYR A  48
PHE A  41
PHE A 135
 None
None
None
None
GOL  A 301 ( 4.9A)
 1.36A 3u9fD-3zphA:
undetectable
3u9fF-3zphA:
undetectable		 3u9fD-3zphA:
22.18
3u9fF-3zphA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		5 / 12 PHE A  50
SER A  37
TYR A  48
PHE A  41
PHE A 135
 None
None
None
None
GOL  A 301 ( 4.9A)
 1.33A 3u9fJ-3zphA:
undetectable
3u9fL-3zphA:
undetectable		 3u9fJ-3zphA:
22.18
3u9fL-3zphA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_O_CLMO221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		5 / 11 PHE A  50
SER A  37
TYR A  48
PHE A  41
PHE A 135
 None
None
None
None
GOL  A 301 ( 4.9A)
 1.40A 3u9fM-3zphA:
undetectable
3u9fO-3zphA:
undetectable		 3u9fM-3zphA:
22.18
3u9fO-3zphA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		4 / 8 TYR A 275
VAL A  32
TYR A 278
ILE A  29
 None
 1.04A 4aftD-3zphA:
undetectable
4aftE-3zphA:
undetectable		 4aftD-3zphA:
22.30
4aftE-3zphA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		4 / 8 TYR A 275
VAL A  32
TYR A 278
ILE A  29
 None
 1.09A 4bqtC-3zphA:
undetectable
4bqtD-3zphA:
undetectable		 4bqtC-3zphA:
22.30
4bqtD-3zphA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		5 / 11 HIS A 256
ILE A 136
LEU A 140
ASP A 214
GLY A 168
 None
 1.26A 4fogC-3zphA:
undetectable		 4fogC-3zphA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		5 / 12 LEU A 190
VAL A 186
MET A 165
ALA A 262
LEU A 252
 None
 1.20A 4ib4A-3zphA:
undetectable		 4ib4A-3zphA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		3 / 3 LYS A 146
LEU A 148
ALA A 201
 None
 0.66A 4iizA-3zphA:
undetectable		 4iizA-3zphA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		5 / 12 LEU A 190
VAL A 186
ALA A 262
PHE A  63
LEU A 252
 None
 1.32A 4nc3A-3zphA:
undetectable		 4nc3A-3zphA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		5 / 12 LEU A 190
VAL A 186
MET A 165
ALA A 262
LEU A 252
 None
 1.16A 4nc3A-3zphA:
undetectable		 4nc3A-3zphA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		4 / 8 TYR A  48
HIS A  74
TRP A  75
PHE A 137
 None
 1.06A 4tzcB-3zphA:
undetectable
4tzcD-3zphA:
undetectable		 4tzcB-3zphA:
17.14
4tzcD-3zphA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 3zph CHALCONE ISOMERASE
(Eubacterium
ramulus) 		4 / 6 GLY A  60
GLN A 224
TYR A 161
TYR A  65
 None
 1.24A 6ag0C-3zphA:
undetectable		 6ag0C-3zphA:
15.25