SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zpj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 3zpj TON_1535
(Thermococcus
onnurineus) 		5 / 10 LEU A 289
GLU A 292
GLU A 347
ILE A 344
GLU A 314
 None
 1.19A 1wopA-3zpjA:
undetectable		 1wopA-3zpjA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 3zpj TON_1535
(Thermococcus
onnurineus) 		4 / 6 LYS A 327
LEU A 323
GLU A 322
LEU A 296
 None
 0.77A 3h5gA-3zpjA:
undetectable
3h5gC-3zpjA:
undetectable		 3h5gA-3zpjA:
7.34
3h5gC-3zpjA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 3zpj TON_1535
(Thermococcus
onnurineus) 		5 / 12 GLY A 169
LEU A 164
SER A 118
GLU A 176
ALA A 125
 None
 1.27A 3sxjA-3zpjA:
undetectable		 3sxjA-3zpjA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 3zpj TON_1535
(Thermococcus
onnurineus) 		5 / 12 GLY A 169
LEU A 164
SER A 118
GLU A 176
ALA A 125
 None
 1.27A 3sxjB-3zpjA:
undetectable		 3sxjB-3zpjA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3zpj TON_1535
(Thermococcus
onnurineus) 		4 / 6 LYS A  22
ILE A   7
VAL A  35
LEU A  36
 None
 1.05A 4em2A-3zpjA:
undetectable		 4em2A-3zpjA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 3zpj TON_1535
(Thermococcus
onnurineus) 		5 / 9 PHE A  97
ALA A 100
ALA A  74
LEU A  67
SER A  82
 None
 1.29A 4or0A-3zpjA:
undetectable		 4or0A-3zpjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3zpj TON_1535
(Thermococcus
onnurineus) 		4 / 7 LEU A 248
LEU A 290
LEU A 244
ALA A 269
 None
 0.60A 4z90F-3zpjA:
undetectable
4z90G-3zpjA:
2.6
4z90H-3zpjA:
1.6
4z90J-3zpjA:
1.5		 4z90F-3zpjA:
21.61
4z90G-3zpjA:
21.61
4z90H-3zpjA:
21.61
4z90J-3zpjA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3zpj TON_1535
(Thermococcus
onnurineus) 		5 / 10 GLY A 225
ILE A 218
ALA A 230
LEU A 231
PHE A 278
 None
 1.28A 5zjiA-3zpjA:
undetectable
5zjiJ-3zpjA:
undetectable		 5zjiA-3zpjA:
13.37
5zjiJ-3zpjA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3zpj TON_1535
(Thermococcus
onnurineus) 		3 / 3 GLU A 314
ASP A 341
PRO A 340
 None
 0.65A 6berA-3zpjA:
undetectable		 6berA-3zpjA:
3.31