SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zpp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A 295
ALA A 270
LYS A 282
THR A 221
ILE A 239
 None
 1.17A 1ddsA-3zppA:
undetectable		 1ddsA-3zppA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 PHE A 219
TYR A 241
LEU A 199
VAL A 185
 None
 1.30A 1dz6A-3zppA:
undetectable		 1dz6A-3zppA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 517
LEU A 510
ILE A 533
ASN A 494
THR A 492
 None
 1.02A 2bdmA-3zppA:
undetectable		 2bdmA-3zppA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLY A 403
ILE A 458
ILE A 473
VAL A 412
ILE A 414
 None
 0.90A 2hs1B-3zppA:
undetectable		 2hs1B-3zppA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PPO_A_DCKA401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 SER A 326
TYR A 401
THR A 372
ASN A 439
TYR A 441
 None
 1.26A 3ppoA-3zppA:
0.1		 3ppoA-3zppA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PPO_B_DCKB401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 SER A 326
TYR A 401
THR A 372
ASN A 439
TYR A 441
 None
 1.29A 3ppoB-3zppA:
0.0		 3ppoB-3zppA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 GLY A 269
SER A 268
SER A 367
THR A 285
 None
 0.67A 3pwwA-3zppA:
undetectable		 3pwwA-3zppA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 THR A 492
VAL A 518
GLU A 521
 None
 0.67A 3v4tA-3zppA:
undetectable
3v4tD-3zppA:
undetectable		 3v4tA-3zppA:
22.36
3v4tD-3zppA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 VAL A 404
VAL A 486
ILE A 473
LEU A 510
VAL A 513
 None
 1.03A 3w68B-3zppA:
undetectable		 3w68B-3zppA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 VAL A 486
ILE A 496
ILE A 508
LEU A 510
VAL A 513
 None
 0.93A 3w68C-3zppA:
undetectable		 3w68C-3zppA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 VAL A 404
VAL A 486
ILE A 473
LEU A 510
VAL A 513
 None
 1.03A 3w68D-3zppA:
undetectable		 3w68D-3zppA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 VAL A 486
ILE A 496
ILE A 508
LEU A 510
VAL A 513
 None
 0.93A 3w68D-3zppA:
undetectable		 3w68D-3zppA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 ALA A 343
TYR A 342
ILE A 273
GLY A 274
 None
 0.62A 4eatA-3zppA:
undetectable		 4eatA-3zppA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ALA A 343
TYR A 342
ALA A 272
ILE A 273
GLY A 274
 None
 0.92A 4eatB-3zppA:
undetectable		 4eatB-3zppA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 TYR A 441
ARG A 431
ASN A 439
ALA A 402
LEU A 437
 None
 1.44A 4oadA-3zppA:
undetectable		 4oadA-3zppA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 THR A 490
ILE A 508
ASN A 461
LEU A 413
VAL A 404
 None
 1.46A 4r3aB-3zppA:
undetectable		 4r3aB-3zppA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A 190
SER A 142
VAL A 176
ASP A 162
 None
 1.25A 5hesA-3zppA:
undetectable		 5hesA-3zppA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 LYS A 349
VAL A 354
LYS A 301
ILE A 297
 None
 1.38A 5q1sA-3zppA:
undetectable		 5q1sA-3zppA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 GLY A 292
GLN A 291
VAL A 371
SER A 326
 None
 1.34A 5vunA-3zppA:
undetectable		 5vunA-3zppA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A 295
ALA A 270
LYS A 282
THR A 221
ILE A 239
 None
 1.25A 5z6fA-3zppA:
undetectable		 5z6fA-3zppA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 THR A 355
LEU A 304
ILE A 281
THR A 280
 None
 0.94A 5zsfA-3zppA:
4.0
5zsfB-3zppA:
4.5		 5zsfA-3zppA:
9.26
5zsfB-3zppA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ASN A 507
ILE A 473
VAL A 491
THR A 492
ILE A 458
 None
 1.16A 6hlpA-3zppA:
undetectable		 6hlpA-3zppA:
20.74