SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zq4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 7 TYR A  25
GLY A  16
ILE A  20
GLY A  39
 None
 0.75A 11gsB-3zq4A:
undetectable		 11gsB-3zq4A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 5 HIS A 368
HIS A  74
HIS A  79
HIS A 390
ASP A 195
 None
ZN  A1557 (-3.0A)
ZN  A1556 (-3.2A)
ZN  A1556 (-3.4A)
None
 1.49A 1e9yB-3zq4A:
2.4		 1e9yB-3zq4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 8 ASP A 195
ASP A 164
HIS A  74
HIS A 368
 None
ZN  A1556 ( 2.7A)
ZN  A1557 (-3.0A)
None
 0.87A 1ei6C-3zq4A:
2.5		 1ei6C-3zq4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 8 ASP A 195
THR A 197
ASP A 164
HIS A  79
HIS A 368
 None
None
ZN  A1556 ( 2.7A)
ZN  A1556 (-3.2A)
None
 1.38A 1ei6C-3zq4A:
2.5		 1ei6C-3zq4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 6 HIS A  79
HIS A 142
HIS A 368
HIS A 390
ASP A  78
 ZN  A1556 (-3.2A)
ZN  A1557 (-3.3A)
None
ZN  A1556 (-3.4A)
ZN  A1556 (-2.5A)
 1.33A 1fweC-3zq4A:
3.4		 1fweC-3zq4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 5 PHE A  71
GLY A  69
THR A 133
PHE A 130
 None
 1.30A 1icuC-3zq4A:
undetectable
1icuD-3zq4A:
undetectable		 1icuC-3zq4A:
16.55
1icuD-3zq4A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 5 PHE A  71
GLY A  69
THR A 133
PHE A 130
 None
 1.27A 1icvA-3zq4A:
undetectable
1icvB-3zq4A:
undetectable		 1icvA-3zq4A:
16.55
1icvB-3zq4A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 8 GLY A 102
ILE A 265
SER A 261
GLU A 264
 None
 0.85A 1mrjA-3zq4A:
undetectable		 1mrjA-3zq4A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		3 / 3 ASP A  78
HIS A 142
ASP A 195
 ZN  A1556 (-2.5A)
ZN  A1557 (-3.3A)
None
 0.85A 1nw5A-3zq4A:
2.8		 1nw5A-3zq4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		3 / 3 ASP A 164
HIS A 390
HIS A 368
 ZN  A1556 ( 2.7A)
ZN  A1556 (-3.4A)
None
 0.61A 1oe1A-3zq4A:
undetectable		 1oe1A-3zq4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		3 / 3 ASP A 164
HIS A 390
HIS A 368
 ZN  A1556 ( 2.7A)
ZN  A1556 (-3.4A)
None
 0.61A 1oe3A-3zq4A:
undetectable		 1oe3A-3zq4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 7 GLN A 522
PHE A 478
ARG A 518
GLU A 525
 None
 1.31A 1t9wA-3zq4A:
undetectable		 1t9wA-3zq4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 12 HIS A  79
GLY A 163
HIS A 390
HIS A 368
SER A 143
 ZN  A1556 (-3.2A)
None
ZN  A1556 (-3.4A)
None
None
 1.23A 2pgfA-3zq4A:
undetectable		 2pgfA-3zq4A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 12 HIS A 390
ILE A  20
HIS A  74
ASP A 164
ASP A 195
 ZN  A1556 (-3.4A)
None
ZN  A1557 (-3.0A)
ZN  A1556 ( 2.7A)
None
 1.30A 2pgfA-3zq4A:
undetectable		 2pgfA-3zq4A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 12 HIS A  79
HIS A 390
ILE A  20
HIS A  74
ASP A 195
 ZN  A1556 (-3.2A)
ZN  A1556 (-3.4A)
None
ZN  A1557 (-3.0A)
None
 1.03A 2pgrA-3zq4A:
undetectable		 2pgrA-3zq4A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 11 ASP A  78
HIS A  79
HIS A 142
ASP A 164
HIS A 390
 ZN  A1556 (-2.5A)
ZN  A1556 (-3.2A)
ZN  A1557 (-3.3A)
ZN  A1556 ( 2.7A)
ZN  A1556 (-3.4A)
 0.65A 2q0jB-3zq4A:
10.8		 2q0jB-3zq4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 12 LEU A  86
ILE A  80
GLY A  96
ALA A  38
ILE A  83
 None
 0.79A 2rkfA-3zq4A:
undetectable		 2rkfA-3zq4A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		3 / 3 ASP A 164
HIS A 390
HIS A 368
 ZN  A1556 ( 2.7A)
ZN  A1556 (-3.4A)
None
 0.63A 2xxgA-3zq4A:
undetectable		 2xxgA-3zq4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		3 / 3 ASP A 164
HIS A 390
HIS A 368
 ZN  A1556 ( 2.7A)
ZN  A1556 (-3.4A)
None
 0.64A 2xxgC-3zq4A:
undetectable		 2xxgC-3zq4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 12 ILE A 435
ASN A 418
GLY A  15
LEU A  60
ASN A  63
 None
 1.02A 2zw9A-3zq4A:
undetectable		 2zw9A-3zq4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 5 HIS A 142
HIS A 368
HIS A 390
ASP A  78
 ZN  A1557 (-3.3A)
None
ZN  A1556 (-3.4A)
ZN  A1556 (-2.5A)
 1.17A 3c0zA-3zq4A:
undetectable		 3c0zA-3zq4A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 5 PRO A 383
VAL A 189
THR A  73
GLY A 149
 None
 1.16A 3elzB-3zq4A:
undetectable		 3elzB-3zq4A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 10 ASP A  78
GLY A  16
GLY A  15
LEU A  14
VAL A 440
 ZN  A1556 (-2.5A)
None
None
None
None
 0.95A 3em4V-3zq4A:
undetectable		 3em4V-3zq4A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 10 GLY A  81
GLY A  82
LEU A  86
VAL A 440
ILE A 442
 None
 0.88A 3em4V-3zq4A:
undetectable		 3em4V-3zq4A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 12 THR A 531
THR A 533
LEU A 512
ILE A 551
ILE A 552
 None
 1.20A 3gwxA-3zq4A:
undetectable		 3gwxA-3zq4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 8 PHE A 219
ILE A 218
PHE A 228
THR A 294
VAL A 222
 None
 1.48A 3me6B-3zq4A:
undetectable		 3me6B-3zq4A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 6 ILE A 242
GLU A 243
PHE A 219
ALA A 245
 None
 1.13A 3pgyA-3zq4A:
undetectable
3pgyB-3zq4A:
undetectable		 3pgyA-3zq4A:
22.01
3pgyB-3zq4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 7 ASP A 164
HIS A 368
ILE A  20
HIS A 390
 ZN  A1556 ( 2.7A)
None
None
ZN  A1556 (-3.4A)
 1.03A 3t01A-3zq4A:
undetectable		 3t01A-3zq4A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 11 PHE A 137
HIS A 161
GLY A 149
GLY A  69
ASN A 120
 None
 1.27A 3v3nA-3zq4A:
undetectable		 3v3nA-3zq4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 8 PHE A 137
GLY A 149
GLY A  69
ASN A 120
 None
 0.92A 3v3nB-3zq4A:
undetectable		 3v3nB-3zq4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 8 PHE A 137
GLY A 149
GLY A  69
ASN A 120
 None
 0.92A 3v3nC-3zq4A:
undetectable		 3v3nC-3zq4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 11 PHE A 137
HIS A 161
GLY A 149
GLY A  69
ASN A 120
 None
 1.27A 3v3nD-3zq4A:
undetectable		 3v3nD-3zq4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 12 PHE A 137
HIS A 161
GLY A 149
GLY A  69
ASN A 120
 None
 1.17A 3v3oA-3zq4A:
undetectable		 3v3oA-3zq4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 7 TYR A  25
HIS A  74
HIS A 368
HIS A 161
 None
ZN  A1557 (-3.0A)
None
None
 1.42A 3zodA-3zq4A:
undetectable		 3zodA-3zq4A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 8 PHE A 130
VAL A 128
ILE A 122
GLU A  32
 None
 0.89A 4a97D-3zq4A:
undetectable		 4a97D-3zq4A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 7 PHE A 130
VAL A 128
ILE A 122
GLU A  32
 None
 1.09A 4a97H-3zq4A:
undetectable		 4a97H-3zq4A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 11 PHE A 137
HIS A 161
GLY A 149
GLY A  69
ASN A 120
 None
 1.30A 4a99D-3zq4A:
undetectable		 4a99D-3zq4A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 8 ASP A 146
SER A 147
ARG A 139
GLY A  96
 None
 1.02A 4af0A-3zq4A:
undetectable		 4af0A-3zq4A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 10 HIS A  74
HIS A  76
ASP A  78
HIS A 142
HIS A 390
 ZN  A1557 (-3.0A)
ZN  A1557 (-3.2A)
ZN  A1556 (-2.5A)
ZN  A1557 (-3.3A)
ZN  A1556 (-3.4A)
 0.82A 4c1dB-3zq4A:
9.8		 4c1dB-3zq4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 11 HIS A  74
HIS A  76
ASP A  78
HIS A 142
HIS A 390
 ZN  A1557 (-3.0A)
ZN  A1557 (-3.2A)
ZN  A1556 (-2.5A)
ZN  A1557 (-3.3A)
ZN  A1556 (-3.4A)
 0.85A 4c1fA-3zq4A:
10.3
4c1fB-3zq4A:
3.5		 4c1fA-3zq4A:
16.34
4c1fB-3zq4A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 9 HIS A  74
HIS A  76
ASP A  78
HIS A 142
HIS A 390
 ZN  A1557 (-3.0A)
ZN  A1557 (-3.2A)
ZN  A1556 (-2.5A)
ZN  A1557 (-3.3A)
ZN  A1556 (-3.4A)
 0.84A 4c1hA-3zq4A:
10.7		 4c1hA-3zq4A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		3 / 3 TYR A 493
MET A 494
ILE A 468
 None
 0.76A 4c8bB-3zq4A:
undetectable		 4c8bB-3zq4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		6 / 12 GLY A  15
GLY A 391
GLY A  16
GLU A 392
VAL A 400
ILE A 415
 None
 1.40A 4ctjA-3zq4A:
undetectable		 4ctjA-3zq4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 8 HIS A  76
ASP A  78
HIS A 142
HIS A 390
 ZN  A1557 (-3.2A)
ZN  A1556 (-2.5A)
ZN  A1557 (-3.3A)
ZN  A1556 (-3.4A)
 0.75A 4exsB-3zq4A:
10.0		 4exsB-3zq4A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 5 HIS A 368
HIS A  74
HIS A  79
HIS A 390
ASP A 195
 None
ZN  A1557 (-3.0A)
ZN  A1556 (-3.2A)
ZN  A1556 (-3.4A)
None
 1.46A 4h9mA-3zq4A:
undetectable		 4h9mA-3zq4A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		3 / 3 ASP A 195
VAL A 160
ASN A  23
 None
None
ZN  A1556 ( 4.7A)
 0.76A 4lmnA-3zq4A:
undetectable		 4lmnA-3zq4A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		3 / 3 LEU A 461
ILE A 460
ARG A 456
 None
 0.71A 4mk4B-3zq4A:
undetectable		 4mk4B-3zq4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 7 HIS A 368
HIS A 390
HIS A  74
HIS A  76
 None
ZN  A1556 (-3.4A)
ZN  A1557 (-3.0A)
ZN  A1557 (-3.2A)
 0.98A 4p6sB-3zq4A:
undetectable		 4p6sB-3zq4A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 12 PHE A 165
GLY A 163
LEU A  17
HIS A 399
LEU A 192
 None
 1.40A 4xldA-3zq4A:
undetectable		 4xldA-3zq4A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 12 VAL A 515
LEU A 507
ILE A 508
LEU A 512
ILE A 530
 None
 1.05A 4y0rA-3zq4A:
1.4		 4y0rA-3zq4A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 12 VAL A  27
VAL A 135
ILE A 150
GLY A 149
LEU A 192
 None
 0.99A 4y8wA-3zq4A:
undetectable		 4y8wA-3zq4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 12 VAL A  27
VAL A 135
ILE A 150
GLY A 149
LEU A 192
 None
 0.98A 4y8wB-3zq4A:
undetectable		 4y8wB-3zq4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		3 / 3 ALA A  26
TYR A  25
PRO A  55
 None
 0.69A 4zdyA-3zq4A:
undetectable		 4zdyA-3zq4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 8 HIS A  76
ASP A  78
HIS A 142
HIS A 390
 ZN  A1557 (-3.2A)
ZN  A1556 (-2.5A)
ZN  A1557 (-3.3A)
ZN  A1556 (-3.4A)
 0.75A 5a5zA-3zq4A:
9.1		 5a5zA-3zq4A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		6 / 11 HIS A  74
HIS A  76
ASP A  78
HIS A  79
HIS A 142
HIS A 390
 ZN  A1557 (-3.0A)
ZN  A1557 (-3.2A)
ZN  A1556 (-2.5A)
ZN  A1556 (-3.2A)
ZN  A1557 (-3.3A)
ZN  A1556 (-3.4A)
 0.37A 5ayaA-3zq4A:
12.2		 5ayaA-3zq4A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 12 SER A 366
HIS A  74
HIS A 142
GLY A 367
ASP A  78
 None
ZN  A1557 (-3.0A)
ZN  A1557 (-3.3A)
None
ZN  A1556 (-2.5A)
 1.11A 5eeiA-3zq4A:
undetectable		 5eeiA-3zq4A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 12 SER A 366
HIS A  74
HIS A 142
GLY A 367
ASP A  78
 None
ZN  A1557 (-3.0A)
ZN  A1557 (-3.3A)
None
ZN  A1556 (-2.5A)
 1.10A 5eeiB-3zq4A:
undetectable		 5eeiB-3zq4A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 9 ILE A  67
VAL A 421
ILE A 435
TYR A  57
LEU A  70
 None
 1.02A 5iepA-3zq4A:
undetectable		 5iepA-3zq4A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 12 THR A 141
THR A 140
ALA A 176
GLY A 369
THR A 205
 None
 1.10A 5lf7V-3zq4A:
undetectable
5lf7b-3zq4A:
undetectable		 5lf7V-3zq4A:
19.27
5lf7b-3zq4A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 12 THR A 141
THR A 140
ALA A 176
GLY A 369
THR A 205
 None
 1.09A 5lf7H-3zq4A:
3.8
5lf7N-3zq4A:
undetectable		 5lf7H-3zq4A:
19.27
5lf7N-3zq4A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 8 ASP A 164
HIS A  74
HIS A  79
HIS A 368
 ZN  A1556 ( 2.7A)
ZN  A1557 (-3.0A)
ZN  A1556 (-3.2A)
None
 0.96A 5nekB-3zq4A:
undetectable		 5nekB-3zq4A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 8 ASP A 164
HIS A  79
HIS A 390
HIS A 142
 ZN  A1556 ( 2.7A)
ZN  A1556 (-3.2A)
ZN  A1556 (-3.4A)
ZN  A1557 (-3.3A)
 0.92A 5nekD-3zq4A:
undetectable		 5nekD-3zq4A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 8 ASP A 164
HIS A 142
HIS A  74
HIS A 390
 ZN  A1556 ( 2.7A)
ZN  A1557 (-3.3A)
ZN  A1557 (-3.0A)
ZN  A1556 (-3.4A)
 0.91A 5nekD-3zq4A:
undetectable		 5nekD-3zq4A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 8 ASP A 164
HIS A 390
HIS A 368
HIS A  74
 ZN  A1556 ( 2.7A)
ZN  A1556 (-3.4A)
None
ZN  A1557 (-3.0A)
 0.90A 5nekD-3zq4A:
undetectable		 5nekD-3zq4A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		6 / 10 HIS A  74
HIS A  76
HIS A  79
HIS A 142
ASP A 164
HIS A 368
 ZN  A1557 (-3.0A)
ZN  A1557 (-3.2A)
ZN  A1556 (-3.2A)
ZN  A1557 (-3.3A)
ZN  A1556 ( 2.7A)
None
 0.33A 5nzwA-3zq4A:
8.4		 5nzwA-3zq4A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 10 HIS A  79
HIS A 390
HIS A  74
ASP A 164
HIS A 142
 ZN  A1556 (-3.2A)
ZN  A1556 (-3.4A)
ZN  A1557 (-3.0A)
ZN  A1556 ( 2.7A)
ZN  A1557 (-3.3A)
 1.11A 5nzwA-3zq4A:
8.4		 5nzwA-3zq4A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		5 / 10 HIS A 142
HIS A  74
HIS A 368
ASP A 164
HIS A 390
 ZN  A1557 (-3.3A)
ZN  A1557 (-3.0A)
None
ZN  A1556 ( 2.7A)
ZN  A1556 (-3.4A)
 0.90A 5nzwA-3zq4A:
8.4		 5nzwA-3zq4A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 8 HIS A  76
ASP A  78
HIS A 142
HIS A 390
 ZN  A1557 (-3.2A)
ZN  A1556 (-2.5A)
ZN  A1557 (-3.3A)
ZN  A1556 (-3.4A)
 0.79A 5zj8A-3zq4A:
10.1		 5zj8A-3zq4A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 3zq4 RIBONUCLEASE J 1
(Bacillus
subtilis) 		4 / 6 ARG A 220
ARG A 250
ALA A 245
THR A 294
 None
 1.10A 6ma6A-3zq4A:
undetectable		 6ma6A-3zq4A:
9.07