SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zq6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 SER A 164
VAL A 166
TRP A 165
PHE A 158
 None
 0.95A 1dmiA-3zq6A:
undetectable
1dmiB-3zq6A:
undetectable		 1dmiA-3zq6A:
20.97
1dmiB-3zq6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 VAL A  84
ARG A 132
ALA A 125
GLU A  87
 None
 1.04A 1dmiA-3zq6A:
undetectable
1dmiB-3zq6A:
undetectable		 1dmiA-3zq6A:
20.97
1dmiB-3zq6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 ASP A 254
GLY A 255
ILE A 251
GLY A  20
ILE A  19
 None
 1.01A 1sh9B-3zq6A:
undetectable		 1sh9B-3zq6A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 VAL A 142
LEU A  56
THR A  50
ILE A  80
ARG A 132
 None
 1.09A 2oipA-3zq6A:
4.7		 2oipA-3zq6A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ALA A 242
LEU A 153
THR A 146
GLY A  26
GLN A 260
 None
None
None
ADP  A 401 (-3.3A)
ADP  A 401 ( 3.9A)
 0.90A 2ve3A-3zq6A:
undetectable		 2ve3A-3zq6A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 MET A 179
ALA A 180
GLY A 177
ILE A 176
 None
 0.66A 2zm9A-3zq6A:
undetectable		 2zm9A-3zq6A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 PHE A 158
SER A 164
VAL A 166
TRP A 165
 None
 0.93A 3dqtA-3zq6A:
0.8
3dqtB-3zq6A:
3.3		 3dqtA-3zq6A:
20.71
3dqtB-3zq6A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 SER A 164
VAL A 166
TRP A 165
PHE A 158
 None
 0.92A 3n5tA-3zq6A:
undetectable
3n5tB-3zq6A:
undetectable		 3n5tA-3zq6A:
20.97
3n5tB-3zq6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 PHE A 158
SER A 164
VAL A 166
TRP A 165
 None
 0.93A 3n61A-3zq6A:
0.7
3n61B-3zq6A:
0.6		 3n61A-3zq6A:
21.35
3n61B-3zq6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 PHE A 158
SER A 164
VAL A 166
TRP A 165
 None
 0.85A 3nlrA-3zq6A:
undetectable
3nlrB-3zq6A:
0.0		 3nlrA-3zq6A:
21.35
3nlrB-3zq6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A 131
LEU A 156
PRO A 159
LEU A 155
 None
 1.04A 3q1eA-3zq6A:
undetectable
3q1eC-3zq6A:
undetectable		 3q1eA-3zq6A:
16.36
3q1eC-3zq6A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 ILE A 141
THR A  15
THR A  14
PHE A   9
 None
 1.15A 3snfA-3zq6A:
undetectable		 3snfA-3zq6A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 PHE A  16
PHE A 144
VAL A 216
ASP A 137
GLN A 129
 None
 1.30A 4c9wA-3zq6A:
undetectable		 4c9wA-3zq6A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 ARG A 174
GLY A 177
ALA A 199
GLU A 196
 None
 1.12A 4g0uA-3zq6A:
3.7		 4g0uA-3zq6A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 PHE A 158
SER A 164
VAL A 166
TRP A 165
 None
 0.97A 4k5jA-3zq6A:
0.7
4k5jB-3zq6A:
undetectable		 4k5jA-3zq6A:
21.23
4k5jB-3zq6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 GLN A 129
PHE A 144
THR A 135
THR A 136
 None
 0.58A 4n16A-3zq6A:
undetectable		 4n16A-3zq6A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 LEU A  46
LEU A  36
LEU A  60
ILE A  64
LEU A  56
 None
 0.96A 4odoA-3zq6A:
undetectable		 4odoA-3zq6A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 LEU A  46
LEU A  36
LEU A  60
ILE A  64
LEU A  56
 None
 1.00A 4odoB-3zq6A:
undetectable		 4odoB-3zq6A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 PHE A 158
SER A 164
VAL A 166
TRP A 165
 None
 0.94A 5adlA-3zq6A:
0.7
5adlB-3zq6A:
3.0		 5adlA-3zq6A:
21.23
5adlB-3zq6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASP A 163
GLU A 204
SER A 218
 None
 0.67A 5bw4B-3zq6A:
undetectable		 5bw4B-3zq6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 PHE A 158
SER A 164
VAL A 166
TRP A 165
 None
 0.95A 5fj3A-3zq6A:
undetectable
5fj3B-3zq6A:
3.4		 5fj3A-3zq6A:
21.23
5fj3B-3zq6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLN A 129
PHE A 144
THR A 135
THR A 136
 None
 0.87A 5m78A-3zq6A:
undetectable		 5m78A-3zq6A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 SER A  31
THR A  28
HIS A  54
ILE A  80
 None
MG  A 403 ( 3.1A)
None
None
 1.24A 5vkqA-3zq6A:
4.4
5vkqB-3zq6A:
4.4		 5vkqA-3zq6A:
10.69
5vkqB-3zq6A:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 SER A  31
THR A  28
HIS A  54
ILE A  80
 None
MG  A 403 ( 3.1A)
None
None
 1.22A 5vkqC-3zq6A:
4.4
5vkqD-3zq6A:
4.4		 5vkqC-3zq6A:
10.69
5vkqD-3zq6A:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 PHE A 158
SER A 164
VAL A 166
TRP A 165
 None
 0.93A 5vv7A-3zq6A:
undetectable
5vv7B-3zq6A:
3.4		 5vv7A-3zq6A:
21.23
5vv7B-3zq6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 PHE A 158
SER A 164
VAL A 166
TRP A 165
 None
 0.91A 5vvnA-3zq6A:
undetectable
5vvnB-3zq6A:
undetectable		 5vvnA-3zq6A:
21.23
5vvnB-3zq6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 SER A 164
VAL A 166
TRP A 165
PHE A 158
 None
 0.96A 6av6A-3zq6A:
0.5
6av6B-3zq6A:
undetectable		 6av6A-3zq6A:
12.42
6av6B-3zq6A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 PHE A 158
SER A 164
VAL A 166
TRP A 165
 None
 0.97A 6av6C-3zq6A:
undetectable
6av6D-3zq6A:
undetectable		 6av6C-3zq6A:
12.42
6av6D-3zq6A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 SER A 164
VAL A 166
TRP A 165
PHE A 158
 None
 0.97A 6av7A-3zq6A:
undetectable
6av7B-3zq6A:
undetectable		 6av7A-3zq6A:
12.42
6av7B-3zq6A:
12.42