SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zqj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 578
GLY A 582
GLU A 847
ARG A 850
LEU A 831
 None
 1.38A 1cmcA-3zqjA:
undetectable
1cmcB-3zqjA:
undetectable		 1cmcA-3zqjA:
8.47
1cmcB-3zqjA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_2
(DIHYDROFOLATE
REDUCTASE)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 4 TYR A 694
ARG A 624
VAL A 648
THR A 628
 None
 1.39A 1dlsA-3zqjA:
0.0		 1dlsA-3zqjA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 8 SER A 441
ILE A 442
LEU A 109
LEU A 420
 None
 0.88A 1eupA-3zqjA:
undetectable		 1eupA-3zqjA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 664
LEU A 668
ALA A 669
ALA A 673
LEU A 695
 None
 1.05A 1jinA-3zqjA:
undetectable		 1jinA-3zqjA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		5 / 12 THR A 650
LEU A 692
LEU A 668
ALA A 669
LEU A 695
 None
 1.37A 1jipA-3zqjA:
undetectable		 1jipA-3zqjA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		3 / 3 THR A 873
THR A 874
PRO A 872
 None
 0.84A 1qfiA-3zqjA:
undetectable		 1qfiA-3zqjA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		3 / 3 SER A 588
GLY A 589
ARG A   4
 None
 0.42A 1t9wA-3zqjA:
undetectable		 1t9wA-3zqjA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.78A 1v54A-3zqjA:
undetectable
1v54J-3zqjA:
undetectable		 1v54A-3zqjA:
18.59
1v54J-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 515
LEU A 511
THR A 554
LEU A 555
 None
 0.99A 1v54N-3zqjA:
undetectable
1v54W-3zqjA:
undetectable		 1v54N-3zqjA:
18.59
1v54W-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		3 / 3 SER A 441
VAL A 105
LEU A 109
 None
 0.70A 1yajG-3zqjA:
undetectable		 1yajG-3zqjA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		3 / 3 THR A 716
PRO A 714
THR A 718
 None
 0.65A 209dC-3zqjA:
undetectable		 209dC-3zqjA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 707
ILE A 706
ASN A 713
SER A 712
 None
 0.91A 2a8tB-3zqjA:
undetectable		 2a8tB-3zqjA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		5 / 10 TYR A 784
VAL A 798
GLY A 719
THR A 716
ALA A 715
 None
 1.11A 2coiA-3zqjA:
undetectable
2coiB-3zqjA:
undetectable		 2coiA-3zqjA:
18.04
2coiB-3zqjA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 719
THR A 716
ALA A 715
TYR A 784
VAL A 798
 None
 1.12A 2cojA-3zqjA:
undetectable
2cojB-3zqjA:
undetectable		 2cojA-3zqjA:
18.04
2cojB-3zqjA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.78A 2dyrA-3zqjA:
undetectable
2dyrJ-3zqjA:
undetectable		 2dyrA-3zqjA:
18.59
2dyrJ-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.80A 2dysA-3zqjA:
undetectable
2dysJ-3zqjA:
undetectable		 2dysA-3zqjA:
18.59
2dysJ-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.79A 2dysN-3zqjA:
undetectable
2dysW-3zqjA:
undetectable		 2dysN-3zqjA:
18.59
2dysW-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.82A 2eijA-3zqjA:
undetectable
2eijJ-3zqjA:
undetectable		 2eijA-3zqjA:
18.59
2eijJ-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.81A 2eilA-3zqjA:
undetectable
2eilJ-3zqjA:
undetectable		 2eilA-3zqjA:
18.59
2eilJ-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 SER A 502
SER A 656
LEU A 533
GLY A 532
 None
 1.04A 2j2pA-3zqjA:
undetectable
2j2pC-3zqjA:
undetectable		 2j2pA-3zqjA:
12.75
2j2pC-3zqjA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 425
PRO A 422
LEU A 420
ARG A 419
 None
 1.42A 2pnjB-3zqjA:
undetectable		 2pnjB-3zqjA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 882
SER A 844
VAL A 829
GLY A 830
 None
 0.96A 2qd5B-3zqjA:
undetectable		 2qd5B-3zqjA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 677
LEU A 698
THR A 865
VAL A 866
 None
 1.02A 2uz2A-3zqjA:
undetectable		 2uz2A-3zqjA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 271
ASP A 266
GLN A 249
GLU A 248
 None
 1.43A 2ya7C-3zqjA:
undetectable		 2ya7C-3zqjA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.77A 2zxwA-3zqjA:
undetectable
2zxwJ-3zqjA:
undetectable		 2zxwA-3zqjA:
18.59
2zxwJ-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 419
ASP A 107
ASN A 276
 None
 0.43A 2zzmA-3zqjA:
undetectable		 2zzmA-3zqjA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 783
ASP A 722
ASN A 747
 None
 0.58A 2zzmA-3zqjA:
undetectable		 2zzmA-3zqjA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.72A 3ablA-3zqjA:
2.9
3ablJ-3zqjA:
undetectable		 3ablA-3zqjA:
18.59
3ablJ-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.69A 3abmA-3zqjA:
undetectable
3abmJ-3zqjA:
undetectable		 3abmA-3zqjA:
18.59
3abmJ-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.82A 3ag3A-3zqjA:
undetectable
3ag3J-3zqjA:
undetectable		 3ag3A-3zqjA:
18.59
3ag3J-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.79A 3asnA-3zqjA:
undetectable
3asnJ-3zqjA:
undetectable		 3asnA-3zqjA:
18.59
3asnJ-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.76A 3asoA-3zqjA:
undetectable
3asoJ-3zqjA:
undetectable		 3asoA-3zqjA:
18.59
3asoJ-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 918
GLY A 926
ILE A 901
SER A 656
VAL A 655
 None
 0.92A 3dcmX-3zqjA:
undetectable		 3dcmX-3zqjA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 577
GLY A 579
ASN A  14
LEU A  33
SER A 805
 None
 1.23A 3mteA-3zqjA:
undetectable		 3mteA-3zqjA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 216
VAL A 205
THR A 224
 None
 0.81A 3ndtA-3zqjA:
undetectable		 3ndtA-3zqjA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 549
LEU A 555
THR A 564
 None
 0.73A 3oxcA-3zqjA:
undetectable		 3oxcA-3zqjA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 GLU A 634
PRO A 296
ARG A 685
GLY A 684
 None
 1.32A 3oxvA-3zqjA:
undetectable		 3oxvA-3zqjA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 CYH A 415
THR A 418
CYH A 285
GLY A 287
 ZN  A1956 (-2.4A)
None
ZN  A1956 (-2.4A)
None
 1.23A 3w9tE-3zqjA:
undetectable		 3w9tE-3zqjA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 565
ARG A 539
THR A 546
LEU A  27
 None
 1.05A 3wg7N-3zqjA:
undetectable
3wg7W-3zqjA:
undetectable		 3wg7N-3zqjA:
18.59
3wg7W-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 251
GLU A 253
ARG A 250
VAL A 222
 None
 1.49A 4jseA-3zqjA:
0.6
4jseB-3zqjA:
undetectable		 4jseA-3zqjA:
17.08
4jseB-3zqjA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 912
VAL A 652
ASN A 889
 None
 0.78A 4lmnA-3zqjA:
undetectable		 4lmnA-3zqjA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 4 HIS A 903
GLU A 528
HIS A 560
LEU A 884
 None
 1.37A 4m2rA-3zqjA:
undetectable		 4m2rA-3zqjA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 528
GLU A 871
GLU A 902
TYR A 605
 None
 1.18A 4mj8A-3zqjA:
undetectable
4mj8C-3zqjA:
undetectable		 4mj8A-3zqjA:
10.85
4mj8C-3zqjA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 824
GLU A 814
ARG A 821
 None
 0.97A 4mwvA-3zqjA:
undetectable		 4mwvA-3zqjA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 159
ASP A 230
GLU A 202
VAL A 205
 None
 1.32A 4nkvB-3zqjA:
undetectable		 4nkvB-3zqjA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 834
LEU A 831
LEU A 843
PHE A 746
 None
 1.01A 4o1zA-3zqjA:
undetectable		 4o1zA-3zqjA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 663
GLY A 631
HIS A 686
VAL A 642
SER A 643
 None
 1.19A 4qd3A-3zqjA:
undetectable		 4qd3A-3zqjA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 515
LEU A 511
THR A 554
LEU A 555
 None
 0.99A 5b1bA-3zqjA:
undetectable
5b1bJ-3zqjA:
undetectable		 5b1bA-3zqjA:
18.59
5b1bJ-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 585
GLY A 575
ARG A 584
THR A  45
LEU A  15
 None
 1.41A 5fhzD-3zqjA:
undetectable		 5fhzD-3zqjA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 812
GLU A 800
GLU A 733
VAL A 791
 None
 1.33A 5h4dA-3zqjA:
undetectable		 5h4dA-3zqjA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.74A 5x1fA-3zqjA:
undetectable
5x1fJ-3zqjA:
undetectable		 5x1fA-3zqjA:
18.59
5x1fJ-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 898
LEU A 885
GLY A 890
LEU A 853
LEU A 869
 None
 1.16A 5x23A-3zqjA:
undetectable		 5x23A-3zqjA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 515
LEU A 511
THR A 554
LEU A 555
 None
 0.97A 5xdqA-3zqjA:
undetectable
5xdqJ-3zqjA:
undetectable		 5xdqA-3zqjA:
18.59
5xdqJ-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.87A 5xdqN-3zqjA:
undetectable
5xdqW-3zqjA:
undetectable		 5xdqN-3zqjA:
18.59
5xdqW-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.77A 5xdxA-3zqjA:
undetectable
5xdxJ-3zqjA:
undetectable		 5xdxA-3zqjA:
18.59
5xdxJ-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA607_0
(ALPHA-AMYLASE)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 4 ARG A 619
SER A 911
ASP A 912
ASN A 889
 None
 1.46A 6ag0A-3zqjA:
undetectable		 6ag0A-3zqjA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 890
ARG A 619
ASN A 889
LEU A 891
 None
 1.22A 6b58A-3zqjA:
3.0		 6b58A-3zqjA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 834
GLY A 832
ILE A 724
ARG A 835
ASP A 803
 None
 1.37A 6c2mC-3zqjA:
undetectable		 6c2mC-3zqjA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 200
ARG A 250
VAL A 205
GLN A 131
 None
 1.18A 6fbvD-3zqjA:
2.2		 6fbvD-3zqjA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  32
SER A  36
ASN A 597
VAL A 586
 None
 1.07A 6giqL-3zqjA:
undetectable
6giqP-3zqjA:
undetectable
6giqT-3zqjA:
undetectable		 6giqL-3zqjA:
18.56
6giqP-3zqjA:
13.53
6giqT-3zqjA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  32
SER A  36
ALA A 578
ASN A 597
VAL A 586
 None
 1.16A 6hu9L-3zqjA:
undetectable
6hu9P-3zqjA:
undetectable
6hu9T-3zqjA:
undetectable		 6hu9L-3zqjA:
17.80
6hu9P-3zqjA:
13.61
6hu9T-3zqjA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 888
ALA A 854
ILE A 881
ASP A 880
PRO A 872
 None
 1.06A 6iftA-3zqjA:
undetectable		 6iftA-3zqjA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		3 / 3 ILE A 914
THR A 650
PRO A 934
 None
 0.62A 6ncsA-3zqjA:
undetectable		 6ncsA-3zqjA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.83A 6nmfA-3zqjA:
1.9
6nmfJ-3zqjA:
undetectable		 6nmfA-3zqjA:
18.59
6nmfJ-3zqjA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zqj UVRABC SYSTEM
PROTEIN A
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 676
ARG A 688
THR A 628
LEU A 627
 None
 0.90A 6nmpA-3zqjA:
undetectable
6nmpJ-3zqjA:
undetectable		 6nmpA-3zqjA:
18.59
6nmpJ-3zqjA:
4.95