SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zrh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 3zrh UBIQUITIN
THIOESTERASE ZRANB1
(Homo
sapiens) 		5 / 12 PHE A 399
LEU A 383
TYR A 433
LEU A 684
LEU A 390
 None
 1.44A 1p33A-3zrhA:
undetectable		 1p33A-3zrhA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3zrh UBIQUITIN
THIOESTERASE ZRANB1
(Homo
sapiens) 		5 / 12 ALA A 519
ALA A 514
LEU A 363
GLY A 518
LEU A 462
 None
 1.25A 1qabF-3zrhA:
undetectable		 1qabF-3zrhA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3zrh UBIQUITIN
THIOESTERASE ZRANB1
(Homo
sapiens) 		3 / 3 LEU A 579
PHE A 586
ARG A 557
 None
 0.85A 1xdkF-3zrhA:
undetectable		 1xdkF-3zrhA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3zrh UBIQUITIN
THIOESTERASE ZRANB1
(Homo
sapiens) 		5 / 10 PHE A 586
ILE A 537
ALA A 451
VAL A 539
LEU A 444
 None
 1.08A 3ay0A-3zrhA:
undetectable		 3ay0A-3zrhA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 3zrh UBIQUITIN
THIOESTERASE ZRANB1
(Homo
sapiens) 		5 / 12 LEU A 411
SER A 447
VAL A 407
GLN A 408
LEU A 403
 None
 1.30A 3m7rA-3zrhA:
undetectable		 3m7rA-3zrhA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3zrh UBIQUITIN
THIOESTERASE ZRANB1
(Homo
sapiens) 		3 / 3 TYR A 373
LEU A 563
ARG A 534
 None
 0.81A 3sufB-3zrhA:
undetectable		 3sufB-3zrhA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3zrh UBIQUITIN
THIOESTERASE ZRANB1
(Homo
sapiens) 		4 / 8 ILE A 330
LEU A 331
VAL A 273
GLY A 272
 None
 0.83A 3w1wA-3zrhA:
undetectable		 3w1wA-3zrhA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3zrh UBIQUITIN
THIOESTERASE ZRANB1
(Homo
sapiens) 		3 / 3 PRO A 618
VAL A 561
HIS A 630
 None
 0.80A 4pevC-3zrhA:
undetectable		 4pevC-3zrhA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 3zrh UBIQUITIN
THIOESTERASE ZRANB1
(Homo
sapiens) 		5 / 11 LEU A 375
LEU A 363
ALA A 465
SER A 469
PHE A 370
 None
 1.16A 4wnuA-3zrhA:
undetectable		 4wnuA-3zrhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 3zrh UBIQUITIN
THIOESTERASE ZRANB1
(Homo
sapiens) 		5 / 12 LEU A 398
VAL A 680
VAL A 590
ARG A 669
GLU A 593
 None
 1.40A 5v1tA-3zrhA:
undetectable		 5v1tA-3zrhA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3zrh UBIQUITIN
THIOESTERASE ZRANB1
(Homo
sapiens) 		5 / 12 VAL A 528
THR A 524
LEU A 375
LEU A 449
VAL A 448
 None
 1.29A 6a93B-3zrhA:
undetectable		 6a93B-3zrhA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 3zrh UBIQUITIN
THIOESTERASE ZRANB1
(Homo
sapiens) 		4 / 5 ARG A 405
TYR A 433
GLN A 395
ILE A 387
 None
 1.39A 6g9bA-3zrhA:
undetectable
6g9bB-3zrhA:
undetectable		 6g9bA-3zrhA:
9.78
6g9bB-3zrhA:
10.60