SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zrp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		5 / 10 GLY A 164
HIS A 135
ALA A 190
THR A 185
ALA A 170
 None
 1.45A 1gtnO-3zrpA:
undetectable
1gtnP-3zrpA:
undetectable		 1gtnO-3zrpA:
12.03
1gtnP-3zrpA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		5 / 9 GLY A 164
HIS A 135
ALA A 190
THR A 185
ALA A 170
 None
 1.40A 1gtnQ-3zrpA:
undetectable
1gtnR-3zrpA:
undetectable		 1gtnQ-3zrpA:
12.03
1gtnR-3zrpA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 342
GLY A 192
SER A 193
ASP A 348
VAL A 274
 None
 1.23A 1i9gA-3zrpA:
undetectable		 1i9gA-3zrpA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		5 / 11 LEU A  41
ALA A 238
ALA A 233
LEU A 202
LEU A 227
 None
 0.98A 1rlbF-3zrpA:
undetectable		 1rlbF-3zrpA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		5 / 12 HIS A 340
HIS A 271
ILE A 278
THR A 300
VAL A 323
 None
 1.47A 2gl0D-3zrpA:
undetectable
2gl0E-3zrpA:
undetectable		 2gl0D-3zrpA:
19.33
2gl0E-3zrpA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		5 / 11 HIS A 340
HIS A 271
ILE A 278
THR A 300
VAL A 323
 None
 1.46A 2gl0E-3zrpA:
undetectable
2gl0F-3zrpA:
1.1		 2gl0E-3zrpA:
19.33
2gl0F-3zrpA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		4 / 8 PHE A  96
LEU A 184
LEU A 200
LEU A  73
 None
 0.82A 2vcvP-3zrpA:
undetectable		 2vcvP-3zrpA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		4 / 7 ASP A 181
ARG A 154
ILE A 150
TYR A  54
 None
 1.15A 2yfbA-3zrpA:
undetectable		 2yfbA-3zrpA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		4 / 6 ASP A 181
ARG A 154
ILE A 150
TYR A  54
 None
 1.17A 2yfbB-3zrpA:
undetectable		 2yfbB-3zrpA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_A_PXLA1197_1
(ASPARTATE
AMINOTRANSFERASE)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		5 / 11 THR A 138
ASP A 163
VAL A 165
SER A 166
LYS A 189
 PLP  A1189 (-2.9A)
PLP  A1189 (-2.8A)
PLP  A1189 (-4.2A)
PLP  A1189 (-3.5A)
PLP  A1189 (-1.3A)
 0.52A 2z9wA-3zrpA:
47.6		 2z9wA-3zrpA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_B_PXLB1197_1
(ASPARTATE
AMINOTRANSFERASE)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		5 / 11 THR A 138
ASP A 163
VAL A 165
SER A 166
LYS A 189
 PLP  A1189 (-2.9A)
PLP  A1189 (-2.8A)
PLP  A1189 (-4.2A)
PLP  A1189 (-3.5A)
PLP  A1189 (-1.3A)
 0.49A 2z9wB-3zrpA:
47.5		 2z9wB-3zrpA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 192
ILE A  58
LEU A  44
VAL A  47
ILE A 259
 None
 1.07A 3adsB-3zrpA:
undetectable		 3adsB-3zrpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		5 / 12 GLY A 192
ILE A  58
LEU A  44
VAL A  47
ILE A 259
 None
 1.00A 3adxB-3zrpA:
undetectable		 3adxB-3zrpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		5 / 9 ALA A  66
LEU A 223
LEU A 202
VAL A 182
SER A 215
 None
 1.18A 3freX-3zrpA:
undetectable		 3freX-3zrpA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		4 / 6 SER A 167
THR A 185
TYR A 183
GLY A 164
 None
 1.15A 3tj7C-3zrpA:
undetectable
3tj7D-3zrpA:
undetectable		 3tj7C-3zrpA:
17.97
3tj7D-3zrpA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		3 / 3 GLY A 111
THR A 140
ASN A  85
 None
 0.69A 3v4tD-3zrpA:
undetectable		 3v4tD-3zrpA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		5 / 11 ALA A 277
SER A 276
PHE A 325
ARG A 279
ILE A 338
 None
 1.49A 4bb2A-3zrpA:
undetectable
4bb2B-3zrpA:
undetectable		 4bb2A-3zrpA:
21.53
4bb2B-3zrpA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		4 / 8 ARG A 143
TRP A 178
GLU A 171
GLU A 172
 None
 1.02A 4bqfB-3zrpA:
2.4		 4bqfB-3zrpA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		5 / 12 LEU A 199
LEU A 200
LEU A 223
GLN A 188
THR A  71
 None
None
None
PLP  A1189 (-3.4A)
None
 1.28A 4f4dA-3zrpA:
undetectable		 4f4dA-3zrpA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		5 / 12 VAL A 290
ALA A 291
VAL A 301
SER A 139
GLY A 141
 None
 1.32A 4mm6A-3zrpA:
undetectable		 4mm6A-3zrpA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		5 / 12 PHE A 336
ILE A 338
VAL A 355
GLY A 281
LEU A 287
 None
 1.19A 5byjA-3zrpA:
undetectable		 5byjA-3zrpA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		4 / 8 SER A  65
ALA A  66
PRO A  60
LEU A 197
 None
 1.15A 5dzkd-3zrpA:
undetectable
5dzkr-3zrpA:
undetectable		 5dzkd-3zrpA:
20.82
5dzkr-3zrpA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		3 / 3 LYS A 261
LEU A 258
ARG A 257
 None
 0.94A 5yw0A-3zrpA:
undetectable		 5yw0A-3zrpA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)
(Sulfolobus
solfataricus) 		6 / 12 SER A 203
VAL A 173
GLY A  49
ALA A  50
SER A 167
VAL A 161
 None
 1.48A 6bqgA-3zrpA:
undetectable		 6bqgA-3zrpA:
12.07