SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zs3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		5 / 10 ALA A 159
GLY A 164
GLU A 184
LEU A 144
PRO A 141
 None
 1.00A 1cmcA-3zs3A:
undetectable
1cmcB-3zs3A:
undetectable		 1cmcA-3zs3A:
18.92
1cmcB-3zs3A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		5 / 12 ALA A 159
GLY A 164
GLU A 184
LEU A 144
PRO A 141
 None
 1.09A 1mj2A-3zs3A:
undetectable
1mj2B-3zs3A:
undetectable		 1mj2A-3zs3A:
17.41
1mj2B-3zs3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		5 / 11 GLU A 184
LEU A 144
PRO A 141
ALA A 159
GLY A 164
 None
 1.08A 1mjqA-3zs3A:
undetectable
1mjqB-3zs3A:
undetectable		 1mjqA-3zs3A:
17.41
1mjqB-3zs3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		5 / 10 GLU A 184
LEU A 144
PRO A 141
ALA A 159
GLY A 164
 None
 1.08A 1mjqC-3zs3A:
undetectable
1mjqD-3zs3A:
undetectable		 1mjqC-3zs3A:
17.41
1mjqD-3zs3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		5 / 12 ALA A 159
GLY A 164
GLU A 184
LEU A 144
PRO A 141
 None
 1.13A 1mjqC-3zs3A:
undetectable
1mjqD-3zs3A:
undetectable		 1mjqC-3zs3A:
17.41
1mjqD-3zs3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		5 / 10 GLU A 184
LEU A 144
PRO A 141
ALA A 159
GLY A 164
 None
 1.08A 1mjqG-3zs3A:
undetectable
1mjqH-3zs3A:
undetectable		 1mjqG-3zs3A:
17.41
1mjqH-3zs3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		5 / 11 GLU A 184
LEU A 144
PRO A 141
ALA A 159
GLY A 164
 None
 1.08A 1mjqI-3zs3A:
undetectable
1mjqJ-3zs3A:
undetectable		 1mjqI-3zs3A:
17.41
1mjqJ-3zs3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		5 / 12 ALA A 159
GLY A 164
GLU A 184
LEU A 144
PRO A 141
 None
 1.12A 1mjqI-3zs3A:
undetectable
1mjqJ-3zs3A:
undetectable		 1mjqI-3zs3A:
17.41
1mjqJ-3zs3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		3 / 3 ALA A  34
VAL A  13
TRP A  14
 None
 0.78A 1nt5A-3zs3A:
undetectable		 1nt5A-3zs3A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		3 / 3 ALA A  34
VAL A  13
TRP A  14
 None
 0.78A 1nt5B-3zs3A:
undetectable		 1nt5B-3zs3A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		4 / 6 PHE A   5
ARG A  39
GLY A  16
THR A  17
 None
 1.19A 2f7fA-3zs3A:
undetectable		 2f7fA-3zs3A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		5 / 12 ALA A  82
VAL A  77
SER A  74
ASN A  80
GLY A  83
 None
FMT  A1231 (-4.2A)
None
None
None
 1.25A 3a65A-3zs3A:
undetectable		 3a65A-3zs3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		5 / 10 PHE A   5
GLY A  30
PHE A  31
VAL A  91
PHE A  51
 None
SIN  A1223 (-4.4A)
None
None
None
 1.34A 3r6wA-3zs3A:
undetectable
3r6wB-3zs3A:
undetectable		 3r6wA-3zs3A:
21.60
3r6wB-3zs3A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		5 / 10 VAL A  91
PHE A  51
PHE A   5
GLY A  30
PHE A  31
 None
None
None
SIN  A1223 (-4.4A)
None
 1.34A 3r6wA-3zs3A:
undetectable
3r6wB-3zs3A:
undetectable		 3r6wA-3zs3A:
21.60
3r6wB-3zs3A:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		5 / 5 SER A  48
GLU A  92
THR A  94
TYR A 103
ASP A 105
 ACT  A1224 ( 3.7A)
ACT  A1224 (-3.9A)
ACT  A1224 (-3.8A)
ACT  A1224 (-4.3A)
ACT  A1224 (-4.2A)
 0.00A 3zs3A-3zs3A:
43.1		 3zs3A-3zs3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZS3_A_ACTA1226_0
(THAUMATIN-LIKE
PROTEIN)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		5 / 5 GLU A 190
TYR A 197
ASP A 202
ASN A 205
PHE A 208
 ACT  A1226 ( 3.9A)
ACT  A1226 ( 4.6A)
ACT  A1226 ( 3.6A)
ACT  A1226 ( 3.8A)
ACT  A1226 (-4.6A)
 0.00A 3zs3A-3zs3A:
43.1		 3zs3A-3zs3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZS3_A_ACTA1227_0
(THAUMATIN-LIKE
PROTEIN)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		4 / 4 THR A  55
ARG A  56
ASN A 137
ILE A 154
 ACT  A1227 (-3.1A)
ACT  A1227 (-3.9A)
ACT  A1227 ( 4.7A)
ACT  A1227 (-4.2A)
 0.01A 3zs3A-3zs3A:
43.1		 3zs3A-3zs3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZS3_A_ACTA1227_0
(THAUMATIN-LIKE
PROTEIN)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		4 / 4 THR A  69
ARG A  56
ASN A 137
ILE A 154
 ACT  A1227 ( 4.4A)
ACT  A1227 (-3.9A)
ACT  A1227 ( 4.7A)
ACT  A1227 (-4.2A)
 1.04A 3zs3A-3zs3A:
43.1		 3zs3A-3zs3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		3 / 3 GLY A  53
THR A  55
ASN A 113
 None
ACT  A1227 (-3.1A)
None
 0.49A 5odiG-3zs3A:
undetectable		 5odiG-3zs3A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 3zs3 THAUMATIN-LIKE
PROTEIN
(Malus
domestica) 		5 / 12 GLN A  25
GLY A  81
VAL A  85
ILE A   3
PHE A  31
 None
 1.14A 6c2mB-3zs3A:
undetectable		 6c2mB-3zs3A:
14.03