SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zs7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		4 / 7 LEU A  98
LEU A   7
MET A  65
MET A  56
 None
 0.99A 1kt3A-3zs7A:
undetectable		 1kt3A-3zs7A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		5 / 10 SER A  11
VAL A  13
HIS A  45
TYR A  84
ASP A 229
 None
None
None
None
ATP  A1301 ( 4.5A)
 0.77A 1td2A-3zs7A:
35.1		 1td2A-3zs7A:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_B_PXLB289_1
(PYRIDOXAMINE KINASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		5 / 9 SER A  11
HIS A  45
TYR A  84
VAL A 119
ASP A 229
 None
None
None
ATP  A1301 ( 3.9A)
ATP  A1301 ( 4.5A)
 0.82A 1td2B-3zs7A:
35.1		 1td2B-3zs7A:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		4 / 6 ALA A 233
TYR A  79
ILE A 115
LEU A  27
 None
 1.03A 1xvaA-3zs7A:
3.9
1xvaB-3zs7A:
3.8		 1xvaA-3zs7A:
22.52
1xvaB-3zs7A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		4 / 8 SER A  11
VAL A  13
VAL A  18
TYR A  84
 None
 0.75A 2ddwA-3zs7A:
30.4		 2ddwA-3zs7A:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		4 / 8 VAL A  13
VAL A  18
LEU A  42
ASP A 229
 None
None
None
ATP  A1301 ( 4.5A)
 0.36A 2ddwA-3zs7A:
30.4		 2ddwA-3zs7A:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		4 / 8 VAL A  13
VAL A  18
TYR A  84
ASP A 229
 None
None
None
ATP  A1301 ( 4.5A)
 0.34A 2ddwA-3zs7A:
30.4		 2ddwA-3zs7A:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		4 / 7 SER A  11
LEU A  42
GLY A 226
ASP A 229
 None
None
ATP  A1301 (-4.1A)
ATP  A1301 ( 4.5A)
 0.80A 2ddwB-3zs7A:
30.8		 2ddwB-3zs7A:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		4 / 6 ILE A  80
TYR A  61
ARG A  93
MET A  65
 None
 1.03A 2einN-3zs7A:
undetectable
2einW-3zs7A:
undetectable		 2einN-3zs7A:
18.92
2einW-3zs7A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		5 / 8 PRO A 118
THR A 147
PRO A 148
VAL A 182
ALA A 143
 None
 1.49A 2v32A-3zs7A:
undetectable
2v32B-3zs7A:
undetectable		 2v32A-3zs7A:
22.51
2v32B-3zs7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_A_BEZA1222_0
(PEROXIREDOXIN 6.)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		5 / 9 THR A 147
PRO A 148
VAL A 182
ALA A 143
PRO A 118
 None
 1.49A 2v41A-3zs7A:
undetectable
2v41B-3zs7A:
undetectable		 2v41A-3zs7A:
22.51
2v41B-3zs7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_B_BEZB1222_0
(PEROXIREDOXIN 6.)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		5 / 9 PRO A 118
THR A 147
PRO A 148
VAL A 182
ALA A 143
 None
 1.49A 2v41A-3zs7A:
undetectable
2v41B-3zs7A:
undetectable		 2v41A-3zs7A:
22.51
2v41B-3zs7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		5 / 12 PRO A 148
ILE A 145
LEU A 235
ILE A 248
ALA A 247
 None
 1.05A 3a50A-3zs7A:
undetectable		 3a50A-3zs7A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		4 / 5 ILE A  80
TYR A  61
ARG A  93
MET A  65
 None
 1.01A 3abkN-3zs7A:
1.2
3abkW-3zs7A:
undetectable		 3abkN-3zs7A:
18.92
3abkW-3zs7A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		4 / 7 ILE A  80
TYR A  61
ARG A  93
MET A  65
 None
 0.96A 3ag4N-3zs7A:
undetectable
3ag4W-3zs7A:
undetectable		 3ag4N-3zs7A:
18.92
3ag4W-3zs7A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		3 / 3 SER A   8
GLY A  83
GLY A  19
 None
 0.53A 3bogA-3zs7A:
undetectable
3bogC-3zs7A:
undetectable		 3bogA-3zs7A:
undetectable
3bogC-3zs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		3 / 3 TYR A  84
TYR A 136
ILE A  91
 None
 0.67A 3eteA-3zs7A:
3.2
3eteB-3zs7A:
3.4		 3eteA-3zs7A:
19.67
3eteB-3zs7A:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		4 / 8 VAL A  18
VAL A  40
HIS A  45
TYR A  84
 None
 0.60A 3fhxB-3zs7A:
36.8		 3fhxB-3zs7A:
39.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		5 / 11 VAL A  18
HIS A  45
TYR A  84
VAL A 119
ASP A 229
 None
None
None
ATP  A1301 ( 3.9A)
ATP  A1301 ( 4.5A)
 0.67A 3mbhA-3zs7A:
33.3		 3mbhA-3zs7A:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		5 / 12 VAL A  18
HIS A  45
TYR A  84
VAL A 119
ASP A 229
 None
None
None
ATP  A1301 ( 3.9A)
ATP  A1301 ( 4.5A)
 0.64A 3mbhB-3zs7A:
32.9		 3mbhB-3zs7A:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		5 / 12 VAL A  18
HIS A  45
TYR A  84
VAL A 119
ASP A 229
 None
None
None
ATP  A1301 ( 3.9A)
ATP  A1301 ( 4.5A)
 0.61A 3mbhC-3zs7A:
33.1		 3mbhC-3zs7A:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		5 / 12 VAL A  18
HIS A  45
TYR A  84
VAL A 119
ASP A 229
 None
None
None
ATP  A1301 ( 3.9A)
ATP  A1301 ( 4.5A)
 0.63A 3mbhD-3zs7A:
33.1		 3mbhD-3zs7A:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		5 / 12 VAL A  18
HIS A  45
TYR A  84
VAL A 119
ASP A 229
 None
None
None
ATP  A1301 ( 3.9A)
ATP  A1301 ( 4.5A)
 0.64A 3mbhE-3zs7A:
33.3		 3mbhE-3zs7A:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		5 / 11 VAL A  18
HIS A  45
TYR A  84
VAL A 119
ASP A 229
 None
None
None
ATP  A1301 ( 3.9A)
ATP  A1301 ( 4.5A)
 0.67A 3mbhF-3zs7A:
33.0		 3mbhF-3zs7A:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		4 / 6 THR A 225
SER A  11
TYR A  84
THR A 227
 None
None
None
ATP  A1301 (-3.4A)
 0.84A 3q70A-3zs7A:
undetectable		 3q70A-3zs7A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		3 / 3 PHE A 238
CYH A 234
HIS A  30
 None
 1.23A 3u9fG-3zs7A:
undetectable		 3u9fG-3zs7A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		3 / 3 PHE A 238
CYH A 234
HIS A  30
 None
 1.25A 3u9fS-3zs7A:
undetectable		 3u9fS-3zs7A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 235
ALA A 232
LEU A  81
ILE A  80
SER A 239
 None
 1.11A 4dm8B-3zs7A:
undetectable		 4dm8B-3zs7A:
22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		4 / 5 SER A  11
HIS A  45
TYR A  84
ASP A 229
 None
None
None
ATP  A1301 ( 4.5A)
 0.79A 4eohB-3zs7A:
36.6		 4eohB-3zs7A:
39.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		3 / 3 MET A  56
GLU A  60
LEU A  64
 None
 0.71A 4v2oB-3zs7A:
undetectable		 4v2oB-3zs7A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		4 / 5 LEU A  81
PHE A 114
ILE A   9
ILE A  94
 None
 0.81A 5dzk4-3zs7A:
undetectable
5dzkg-3zs7A:
undetectable
5dzkm-3zs7A:
undetectable
5dzkn-3zs7A:
undetectable		 5dzk4-3zs7A:
0.85
5dzkg-3zs7A:
22.62
5dzkm-3zs7A:
23.15
5dzkn-3zs7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		4 / 6 ILE A 115
ALA A 232
LEU A 235
ILE A 183
 None
 0.77A 5mvmB-3zs7A:
undetectable
5mvmC-3zs7A:
undetectable		 5mvmB-3zs7A:
18.18
5mvmC-3zs7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 156
VAL A 146
ILE A 115
THR A 113
LEU A 112
 None
 1.29A 5tiwA-3zs7A:
undetectable		 5tiwA-3zs7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		4 / 6 SER A 166
ALA A 153
SER A 154
ALA A 167
 None
 1.03A 6bocA-3zs7A:
undetectable
6bocB-3zs7A:
undetectable
6bocC-3zs7A:
undetectable
6bocD-3zs7A:
undetectable		 6bocA-3zs7A:
6.92
6bocB-3zs7A:
6.92
6bocC-3zs7A:
6.92
6bocD-3zs7A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3zs7 PYRIDOXAL KINASE
(Trypanosoma
brucei) 		5 / 12 PRO A 148
ILE A 183
ILE A 115
HIS A 181
HIS A 175
 None
 1.46A 6j21A-3zs7A:
undetectable		 6j21A-3zs7A:
20.18