SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zsc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		5 / 12 PHE A 226
PRO A 227
PHE A 260
PRO A 262
MET A 253
 None
 1.30A 1fm4A-3zscA:
undetectable		 1fm4A-3zscA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		5 / 9 GLY A 168
GLY A 179
GLU A 173
ARG A 202
GLY A 204
 None
None
None
AQA  A1338 (-2.8A)
None
 1.30A 1l5kA-3zscA:
undetectable		 1l5kA-3zscA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		5 / 12 PRO A 199
GLY A 168
SER A 169
ALA A 237
ALA A 234
 None
 1.18A 1nw5A-3zscA:
undetectable		 1nw5A-3zscA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		4 / 7 ASP A 139
ASP A 115
ASP A 117
HIS A 161
 AQA  A1338 (-3.9A)
None
None
None
 1.45A 1t03A-3zscA:
undetectable		 1t03A-3zscA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		5 / 10 ASN A  92
VAL A  93
TYR A  48
GLY A  23
LEU A  67
 None
 0.97A 3lp1A-3zscA:
undetectable		 3lp1A-3zscA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		4 / 5 ARG A 197
ASP A 117
ASP A 139
ASP A 115
 AQA  A1338 (-3.2A)
None
AQA  A1338 (-3.9A)
None
 1.13A 3naiA-3zscA:
undetectable		 3naiA-3zscA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_B_URFB521_1
(RNA DEPENDENT RNA
POLYMERASE)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		4 / 4 ARG A 197
ASP A 117
ASP A 139
ASP A 115
 AQA  A1338 (-3.2A)
None
AQA  A1338 (-3.9A)
None
 1.10A 3naiB-3zscA:
undetectable		 3naiB-3zscA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		4 / 5 ARG A 197
ASP A 117
ASP A 139
ASP A 115
 AQA  A1338 (-3.2A)
None
AQA  A1338 (-3.9A)
None
 1.00A 3naiC-3zscA:
undetectable		 3naiC-3zscA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		5 / 11 ALA A 234
GLY A 271
TYR A 272
ALA A 178
TYR A 182
 None
 1.46A 3qxyB-3zscA:
undetectable
3qxyQ-3zscA:
undetectable		 3qxyB-3zscA:
20.13
3qxyQ-3zscA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		6 / 12 GLY A 137
GLY A  83
GLY A 102
GLU A  63
VAL A  52
ILE A  98
 None
 1.26A 4ctjA-3zscA:
undetectable		 4ctjA-3zscA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		3 / 3 ASP A 143
ARG A 197
ASP A 115
 None
AQA  A1338 (-3.2A)
None
 0.86A 4fzvA-3zscA:
undetectable		 4fzvA-3zscA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		5 / 11 ILE A  95
SER A 148
ILE A 144
ILE A 119
THR A  71
 None
 1.33A 4p68A-3zscA:
undetectable		 4p68A-3zscA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		5 / 12 GLY A   8
ASN A  92
THR A  71
VAL A 121
HIS A 187
 None
 1.20A 5d0yA-3zscA:
undetectable		 5d0yA-3zscA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		5 / 12 ASP A 139
LYS A 163
PHE A 116
GLY A 137
TYR A 104
 AQA  A1338 (-3.9A)
AQA  A1338 (-3.0A)
None
None
None
 1.03A 5hfjE-3zscA:
undetectable		 5hfjE-3zscA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		5 / 12 ASP A 139
LYS A 163
PHE A 116
GLY A 137
TYR A 104
 AQA  A1338 (-3.9A)
AQA  A1338 (-3.0A)
None
None
None
 1.08A 5hfjG-3zscA:
undetectable		 5hfjG-3zscA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		5 / 12 ASP A 139
LYS A 163
PHE A 116
GLY A 137
TYR A 104
 AQA  A1338 (-3.9A)
AQA  A1338 (-3.0A)
None
None
None
 1.05A 5hfjH-3zscA:
undetectable		 5hfjH-3zscA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		5 / 12 ALA A 280
ASN A 210
LEU A 312
VAL A 315
LEU A 273
 None
 1.04A 5x24A-3zscA:
undetectable		 5x24A-3zscA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		4 / 7 LEU A 166
ASP A 143
ASP A 117
ARG A 197
 AQA  A1338 ( 4.8A)
None
None
AQA  A1338 (-3.2A)
 1.42A 6g31D-3zscA:
undetectable		 6g31D-3zscA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		4 / 4 LEU A 166
ASP A 143
ASP A 117
ARG A 197
 AQA  A1338 ( 4.8A)
None
None
AQA  A1338 (-3.2A)
 1.49A 6g31E-3zscA:
undetectable		 6g31E-3zscA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		5 / 12 THR A 185
SER A 165
PHE A 158
ASN A 156
ASN A 211
 None
 1.33A 6h7jB-3zscA:
undetectable		 6h7jB-3zscA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 3zsc PECTATE
TRISACCHARIDE-LYASE
(Thermotoga
maritima) 		5 / 9 ASN A 156
ILE A  72
ILE A  94
GLU A  63
VAL A  66
 None
 1.30A 6hloA-3zscA:
undetectable		 6hloA-3zscA:
20.30