SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zt9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		5 / 9 ASN A 103
GLU A 154
PRO A 117
ALA A  98
ILE A 100
 None
 1.40A 1aj6A-3zt9A:
undetectable		 1aj6A-3zt9A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		5 / 12 ILE A  40
ALA A  49
LEU A 124
ILE A 104
THR A  79
 None
 1.17A 1ddsA-3zt9A:
undetectable		 1ddsA-3zt9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		5 / 12 ILE A  40
ALA A  49
LEU A 124
ILE A 104
THR A  79
 None
 1.16A 1jolA-3zt9A:
undetectable		 1jolA-3zt9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		4 / 4 LEU A   4
VAL A  89
CYH A  87
ALA A  98
 None
 1.06A 1mz9E-3zt9A:
undetectable		 1mz9E-3zt9A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		5 / 12 ILE A 123
VAL A  83
ASP A  38
ALA A  55
SER A  56
 None
None
MN  A1195 ( 2.6A)
None
None
 0.98A 1nbiA-3zt9A:
undetectable		 1nbiA-3zt9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		5 / 12 ILE A 123
VAL A  83
ASP A  38
ALA A  55
SER A  56
 None
None
MN  A1195 ( 2.6A)
None
None
 0.99A 1nbiB-3zt9A:
undetectable		 1nbiB-3zt9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		5 / 10 ILE A  40
ALA A  49
LEU A 124
ILE A 104
THR A  79
 None
 1.08A 1rb3A-3zt9A:
undetectable		 1rb3A-3zt9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		4 / 6 LEU A 175
LYS A 179
ARG A 183
GLY A 181
 None
 1.19A 2hs2B-3zt9A:
undetectable		 2hs2B-3zt9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		4 / 8 ASP A  38
SER A 149
TYR A   9
CYH A  19
 MN  A1195 ( 2.6A)
None
None
None
 1.22A 2xz5A-3zt9A:
undetectable
2xz5C-3zt9A:
undetectable		 2xz5A-3zt9A:
19.69
2xz5C-3zt9A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		4 / 8 ASP A  38
SER A 149
TYR A   9
CYH A  19
 MN  A1195 ( 2.6A)
None
None
None
 1.24A 2xz5C-3zt9A:
undetectable
2xz5D-3zt9A:
undetectable		 2xz5C-3zt9A:
19.69
2xz5D-3zt9A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		6 / 12 ILE A  40
ALA A  84
GLY A  37
GLY A  39
LEU A  65
PHE A  69
 None
None
None
MN  A1194 (-4.2A)
None
None
 1.48A 2y7hB-3zt9A:
undetectable		 2y7hB-3zt9A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		6 / 12 ILE A  40
ALA A  84
GLY A  37
GLY A  39
LEU A  65
PHE A  69
 None
None
None
MN  A1194 (-4.2A)
None
None
 1.48A 2y7hC-3zt9A:
undetectable		 2y7hC-3zt9A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		4 / 4 GLY A  37
ASP A  21
GLY A  41
THR A  79
 None
MN  A1195 ( 4.6A)
MN  A1194 (-3.9A)
None
 1.08A 3k4vC-3zt9A:
undetectable		 3k4vC-3zt9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		5 / 12 ILE A  40
ALA A  49
LEU A 124
ILE A 104
THR A  79
 None
 1.11A 4ptjA-3zt9A:
undetectable		 4ptjA-3zt9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		5 / 11 ILE A  40
ALA A  49
LEU A 124
ILE A 104
THR A  79
 None
 1.14A 4qleB-3zt9A:
undetectable		 4qleB-3zt9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		5 / 11 ILE A  40
ALA A  49
LEU A 124
ILE A 104
THR A  79
 None
 1.14A 4qlfA-3zt9A:
undetectable		 4qlfA-3zt9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		5 / 12 ILE A  40
ALA A  49
LEU A 124
ILE A 104
THR A  79
 None
 1.12A 4qlgB-3zt9A:
undetectable		 4qlgB-3zt9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		5 / 12 ILE A  40
ALA A  49
LEU A 124
ILE A 104
THR A  79
 None
 1.11A 4rgcA-3zt9A:
undetectable		 4rgcA-3zt9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		5 / 12 ILE A  40
ALA A  49
LEU A 124
ILE A 104
THR A  79
 None
 1.12A 4x5fA-3zt9A:
undetectable		 4x5fA-3zt9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		5 / 12 ILE A  40
ALA A  49
LEU A 124
ILE A 104
THR A  79
 None
 1.11A 4x5fB-3zt9A:
undetectable		 4x5fB-3zt9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		5 / 12 ILE A  40
ALA A  49
LEU A 124
ILE A 104
THR A  79
 None
 1.11A 4x5gA-3zt9A:
undetectable		 4x5gA-3zt9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		5 / 12 ILE A 147
GLY A  37
ALA A 119
ILE A  68
MET A  57
 None
 1.21A 5igyA-3zt9A:
undetectable		 5igyA-3zt9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 3zt9 SERINE PHOSPHATASE
(Moorella
thermoacetica) 		5 / 12 VAL A  25
ILE A  32
VAL A   6
GLY A   7
ILE A   8
 None
 0.55A 5j2tC-3zt9A:
undetectable		 5j2tC-3zt9A:
17.74