SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zta'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1J8U_A_H4BA429_1 (PHENYLALANINE-4-HYDR OXYLASE)	3zta	ANTI-SIGMA-FACTOR ANTAGONIST (STAS) DOMAIN PROTEIN (Moorella thermoacetica)	4 / 7	VAL A 66 LEU A 122 SER A 120 PHE A 121	None	0.77A	1j8uA-3ztaA: undetectable	1j8uA-3ztaA: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B2S_A_ACTA107_0 (CRISPR-ASSOCIATED ENDONUCLEASE CAS9 GUIDE RNA)	3zta	ANTI-SIGMA-FACTOR ANTAGONIST (STAS) DOMAIN PROTEIN (Moorella thermoacetica)	3 / 3	VAL A 13 THR A 37 ARG A 38	None	0.78A	5b2sB-3ztaA: undetectable	5b2sB-3ztaA: 7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B2T_A_ACTA108_0 (CRISPR-ASSOCIATED ENDONUCLEASE CAS9 GUIDE RNA)	3zta	ANTI-SIGMA-FACTOR ANTAGONIST (STAS) DOMAIN PROTEIN (Moorella thermoacetica)	3 / 3	VAL A 13 THR A 37 ARG A 38	None	0.76A	5b2tB-3ztaA: undetectable	5b2tB-3ztaA: 7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JMN_A_FUAA1101_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	3zta	ANTI-SIGMA-FACTOR ANTAGONIST (STAS) DOMAIN PROTEIN (Moorella thermoacetica)	4 / 5	ILE A 12 ILE A 115 HIS A 114 VAL A 111	None	0.77A	5jmnA-3ztaA: undetectable	5jmnA-3ztaA: 8.66

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1J8U_A_H4BA429_1","PHENYLALANINE-4-HYDROXYLASE","3zta","ANTI-SIGMA-FACTOR ANTAGONIST (STAS) DOMAIN PROTEIN","Moorella thermoacetica",4,"VAL A  66;LEU A 122;SER A 120;PHE A 121","None","0.77A","1j8uA-3ztaA:undetectable","1j8uA-3ztaA:18.15"],["5B2S_A_ACTA107_0","CRISPR-ASSOCIATED ENDONUCLEASE CAS9;GUIDE RNA","3zta","ANTI-SIGMA-FACTOR ANTAGONIST (STAS) DOMAIN PROTEIN","Moorella thermoacetica",3,"VAL A  13;THR A  37;ARG A  38","None","0.78A","5b2sB-3ztaA:undetectable","5b2sB-3ztaA:7.84"],["5B2T_A_ACTA108_0","CRISPR-ASSOCIATED ENDONUCLEASE CAS9;GUIDE RNA","3zta","ANTI-SIGMA-FACTOR ANTAGONIST (STAS) DOMAIN PROTEIN","Moorella thermoacetica",3,"VAL A  13;THR A  37;ARG A  38","None","0.76A","5b2tB-3ztaA:undetectable","5b2tB-3ztaA:7.84"],["5JMN_A_FUAA1101_1","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","3zta","ANTI-SIGMA-FACTOR ANTAGONIST (STAS) DOMAIN PROTEIN","Moorella thermoacetica",4,"ILE A  12;ILE A 115;HIS A 114;VAL A 111","None","0.77A","5jmnA-3ztaA:undetectable","5jmnA-3ztaA:8.66"]]