SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zth'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3zth STU0660
(Streptococcus
thermophilus) 		5 / 12 ILE A  80
LEU A 225
PHE A 184
LEU A  97
ILE A  78
 None
 1.09A 1cd2A-3zthA:
undetectable		 1cd2A-3zthA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3zth STU0660
(Streptococcus
thermophilus) 		5 / 12 ILE A  80
LEU A 185
PHE A 184
LEU A  97
ILE A  78
 None
 1.04A 1rb2B-3zthA:
undetectable		 1rb2B-3zthA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 7 GLY A  25
MET A 304
ILE A 256
VAL A  24
 None
 1.05A 1rxcC-3zthA:
undetectable		 1rxcC-3zthA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 5 ASN A  27
THR A 302
MET A 304
GLN A  26
 None
None
None
MG  A1349 (-3.0A)
 1.42A 1xmuA-3zthA:
undetectable		 1xmuA-3zthA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 5 ASN A  27
THR A 302
MET A 304
GLN A  26
 None
None
None
MG  A1349 (-3.0A)
 1.47A 1xmuB-3zthA:
undetectable		 1xmuB-3zthA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 7 SER A 251
LEU A 321
PHE A 289
ILE A 246
 None
 0.93A 2v0mC-3zthA:
undetectable		 2v0mC-3zthA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 7 ILE A 256
LEU A 300
PHE A 325
ARG A 252
 None
 1.05A 3ag4N-3zthA:
undetectable
3ag4W-3zthA:
undetectable		 3ag4N-3zthA:
21.50
3ag4W-3zthA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 8 PHE A  83
PHE A 172
ILE A 178
PHE A 184
 None
 0.87A 3ko0O-3zthA:
undetectable
3ko0Q-3zthA:
undetectable		 3ko0O-3zthA:
15.71
3ko0Q-3zthA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 6 GLY A  25
MET A 304
ILE A 256
VAL A  24
 None
 1.09A 3kvvA-3zthA:
undetectable		 3kvvA-3zthA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 6 GLY A  25
MET A 304
ILE A 256
VAL A  24
 None
 1.06A 3kvvB-3zthA:
undetectable		 3kvvB-3zthA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 6 GLY A  25
MET A 304
ILE A 256
VAL A  24
 None
 1.05A 3kvvC-3zthA:
undetectable		 3kvvC-3zthA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 6 GLY A  25
MET A 304
ILE A 256
VAL A  24
 None
 1.05A 3kvvD-3zthA:
undetectable		 3kvvD-3zthA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 6 GLY A  25
MET A 304
ILE A 256
VAL A  24
 None
 1.07A 3kvvE-3zthA:
undetectable		 3kvvE-3zthA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 6 GLY A  25
MET A 304
ILE A 256
VAL A  24
 None
 1.09A 3kvvF-3zthA:
undetectable		 3kvvF-3zthA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 3zth STU0660
(Streptococcus
thermophilus) 		5 / 11 ILE A 246
SER A 251
ILE A 256
VAL A  24
VAL A 254
 None
 0.82A 3kw4A-3zthA:
undetectable		 3kw4A-3zthA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 7 GLY A  25
MET A 304
ILE A 256
VAL A  24
 None
 1.07A 4e1vB-3zthA:
undetectable		 4e1vB-3zthA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 6 GLY A  25
MET A 304
ILE A 256
VAL A  24
 None
 1.13A 4e1vF-3zthA:
undetectable		 4e1vF-3zthA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 7 TYR A  47
LEU A  52
TRP A  40
TYR A  33
 None
 1.22A 4f8yC-3zthA:
undetectable
4f8yD-3zthA:
undetectable		 4f8yC-3zthA:
19.71
4f8yD-3zthA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 3zth STU0660
(Streptococcus
thermophilus) 		3 / 3 PHE A  55
TYR A  41
TYR A  47
 None
 1.06A 4ffwA-3zthA:
undetectable		 4ffwA-3zthA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 3zth STU0660
(Streptococcus
thermophilus) 		5 / 12 ILE A  80
ILE A 222
PHE A 184
LEU A 192
ILE A  78
 None
 1.04A 4km0B-3zthA:
undetectable		 4km0B-3zthA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 6 ILE A 256
ILE A 246
PHE A 325
LEU A 321
 None
 0.89A 4m51A-3zthA:
undetectable		 4m51A-3zthA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 7 ILE A 246
VAL A 202
PHE A 234
PHE A 237
 None
 0.95A 5hieC-3zthA:
undetectable		 5hieC-3zthA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 8 THR A 285
PRO A 284
TYR A 278
VAL A 316
 None
 1.02A 5nzyA-3zthA:
undetectable		 5nzyA-3zthA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OAJ_E_TKTE601_1
()		 3zth STU0660
(Streptococcus
thermophilus) 		4 / 8 GLU A 294
CYH A 223
PHE A 218
TYR A 215
 None
 1.39A 5oajD-3zthA:
undetectable
5oajE-3zthA:
undetectable		 5oajD-3zthA:
20.66
5oajE-3zthA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3zth STU0660
(Streptococcus
thermophilus) 		5 / 12 ILE A 201
PHE A 184
LEU A 183
PHE A 172
LEU A 203
 None
 1.12A 5xxiA-3zthA:
undetectable		 5xxiA-3zthA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3zth STU0660
(Streptococcus
thermophilus) 		5 / 11 ILE A  80
LEU A 185
PHE A 184
LEU A  97
ILE A  78
 None
 1.08A 5z6mA-3zthA:
undetectable		 5z6mA-3zthA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 3zth STU0660
(Streptococcus
thermophilus) 		5 / 12 VAL A  70
VAL A 226
PHE A   3
PHE A  42
ILE A  20
 None
 1.36A 6becA-3zthA:
undetectable
6becB-3zthA:
undetectable
6becC-3zthA:
undetectable		 6becA-3zthA:
21.66
6becB-3zthA:
21.66
6becC-3zthA:
21.66