SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zto'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 3zto NUCLEOSIDE
DIPHOSPHATE KINASE
(Aquifex
aeolicus) 		5 / 12 ILE A  89
ILE A 106
ALA A  98
ARG A  85
GLU A  30
 None
 1.48A 1ki7B-3ztoA:
undetectable		 1ki7B-3ztoA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3zto NUCLEOSIDE
DIPHOSPHATE KINASE
(Aquifex
aeolicus) 		5 / 12 ILE A  89
ILE A  34
LEU A  77
VAL A  86
ILE A   8
 None
 0.75A 1oipA-3ztoA:
undetectable		 1oipA-3ztoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 3zto NUCLEOSIDE
DIPHOSPHATE KINASE
(Aquifex
aeolicus) 		5 / 12 ILE A  89
ILE A 141
VAL A  86
ILE A   8
ILE A 132
 None
 1.03A 1r5lA-3ztoA:
undetectable		 1r5lA-3ztoA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 3zto NUCLEOSIDE
DIPHOSPHATE KINASE
(Aquifex
aeolicus) 		4 / 6 MET A  67
VAL A  64
LEU A  63
PHE A  59
 None
None
SO4  A 200 ( 4.7A)
None
 0.95A 1x8vA-3ztoA:
undetectable		 1x8vA-3ztoA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 3zto NUCLEOSIDE
DIPHOSPHATE KINASE
(Aquifex
aeolicus) 		4 / 5 ALA A 108
GLN A 109
ILE A 106
ARG A  26
 None
 1.46A 2z0aA-3ztoA:
undetectable		 2z0aA-3ztoA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3zto NUCLEOSIDE
DIPHOSPHATE KINASE
(Aquifex
aeolicus) 		5 / 12 ILE A  89
VAL A  10
VAL A  73
LEU A  37
ILE A  34
 None
 0.96A 3gwxB-3ztoA:
undetectable		 3gwxB-3ztoA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 3zto NUCLEOSIDE
DIPHOSPHATE KINASE
(Aquifex
aeolicus) 		4 / 6 HIS A 120
GLU A 131
ASP A 123
SER A 127
 SO4  A 200 (-3.9A)
None
None
None
 1.19A 4apjA-3ztoA:
undetectable
4apjP-3ztoA:
undetectable		 4apjA-3ztoA:
13.67
4apjP-3ztoA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3zto NUCLEOSIDE
DIPHOSPHATE KINASE
(Aquifex
aeolicus) 		4 / 7 ILE A 135
ILE A   8
PHE A  40
LEU A  77
 None
 0.67A 5fukA-3ztoA:
undetectable
5fukB-3ztoA:
undetectable		 5fukA-3ztoA:
19.49
5fukB-3ztoA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3zto NUCLEOSIDE
DIPHOSPHATE KINASE
(Aquifex
aeolicus) 		5 / 12 ILE A  89
ILE A  34
LEU A  77
VAL A  86
ILE A   8
 None
 0.78A 5mueA-3ztoA:
undetectable		 5mueA-3ztoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3zto NUCLEOSIDE
DIPHOSPHATE KINASE
(Aquifex
aeolicus) 		5 / 12 ILE A  89
ILE A  34
LEU A  77
VAL A  86
ILE A   8
 None
 0.74A 5mugA-3ztoA:
undetectable		 5mugA-3ztoA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEH_A_RPTA601_1
(SCAFFOLD PROTEIN D13)		 3zto NUCLEOSIDE
DIPHOSPHATE KINASE
(Aquifex
aeolicus) 		5 / 10 GLU A 140
PHE A 136
SER A 122
PHE A  50
PHE A  42
 None
 1.45A 6behA-3ztoA:
0.2
6behB-3ztoA:
0.0
6behC-3ztoA:
0.9		 6behA-3ztoA:
15.46
6behB-3ztoA:
15.46
6behC-3ztoA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3zto NUCLEOSIDE
DIPHOSPHATE KINASE
(Aquifex
aeolicus) 		4 / 7 GLY A 111
PHE A 110
VAL A  10
SER A 105
 None
 0.98A 6hu9S-3ztoA:
undetectable
6hu9q-3ztoA:
undetectable		 6hu9S-3ztoA:
17.48
6hu9q-3ztoA:
19.87