SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zty'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Thermus
thermophilus) 		5 / 10 GLU A  58
GLU A 139
ALA A 171
ALA A 172
GLY A 174
 None
 1.30A 1mjqG-3ztyA:
undetectable
1mjqH-3ztyA:
undetectable		 1mjqG-3ztyA:
17.70
1mjqH-3ztyA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Thermus
thermophilus) 		4 / 6 GLY A   9
THR A  10
LEU A  11
GLU A  14
 GD  A 262 ( 4.4A)
None
None
GD  A 262 (-3.0A)
 0.87A 3ps9A-3ztyA:
undetectable		 3ps9A-3ztyA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 LEU A 113
GLY A 111
GLY A 109
THR A 140
 None
 0.96A 3si7A-3ztyA:
undetectable		 3si7A-3ztyA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 TYR A 137
GLU A 139
TYR A 110
 None
 0.94A 3ug8A-3ztyA:
undetectable		 3ug8A-3ztyA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 PRO A  34
PRO A  54
LEU A  65
VAL A  71
ALA A 194
 None
 1.08A 4a84A-3ztyA:
undetectable		 4a84A-3ztyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Thermus
thermophilus) 		4 / 6 GLU A  23
GLU A 244
TYR A 241
GLU A 237
 None
 1.19A 4mi4A-3ztyA:
undetectable		 4mi4A-3ztyA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Thermus
thermophilus) 		4 / 7 GLU A  23
GLU A 244
TYR A 241
GLU A 237
 None
 1.23A 4mi4A-3ztyA:
undetectable
4mi4C-3ztyA:
undetectable		 4mi4A-3ztyA:
23.83
4mi4C-3ztyA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Thermus
thermophilus) 		4 / 8 GLU A  23
GLU A 244
TYR A 241
GLU A 237
 None
 1.20A 4mj8A-3ztyA:
undetectable
4mj8C-3ztyA:
undetectable		 4mj8A-3ztyA:
22.51
4mj8C-3ztyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Thermus
thermophilus) 		4 / 7 THR A 140
ALA A 132
ALA A 115
THR A 122
 None
 0.98A 4qw0K-3ztyA:
undetectable		 4qw0K-3ztyA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Thermus
thermophilus) 		4 / 7 THR A 140
ALA A 132
ALA A 115
THR A 122
 None
 0.97A 4qw0Y-3ztyA:
undetectable		 4qw0Y-3ztyA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Thermus
thermophilus) 		4 / 6 ARG A 185
ARG A 195
VAL A 213
ASP A 214
 None
 1.35A 4xqeA-3ztyA:
5.0		 4xqeA-3ztyA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Thermus
thermophilus) 		4 / 6 ARG A 185
ARG A 195
VAL A 213
ASP A 214
 None
 1.30A 4xqeB-3ztyA:
4.9		 4xqeB-3ztyA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Thermus
thermophilus) 		4 / 8 ASP A 202
ASP A   6
ASP A 206
ILE A  56
 GD  A 261 (-2.4A)
GD  A 261 ( 2.9A)
None
None
 1.05A 5cfsA-3ztyA:
undetectable		 5cfsA-3ztyA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Thermus
thermophilus) 		5 / 11 LEU A  25
ALA A  24
LEU A 200
MET A   1
LEU A 248
 None
 1.38A 5hyrB-3ztyA:
undetectable		 5hyrB-3ztyA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 ARG A 185
PHE A 210
PHE A 196
 None
 0.81A 6nknC-3ztyA:
undetectable
6nknJ-3ztyA:
undetectable		 6nknC-3ztyA:
19.19
6nknJ-3ztyA:
12.89