SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3zu4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1427_0
(FPRA)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		4 / 4 HIS A  16
PRO A   5
LYS A   4
ILE A   3
 None
 1.38A 1lquA-3zu4A:
1.2		 1lquA-3zu4A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 12 THR A 192
SER A 239
LEU A 181
ALA A 278
ALA A 281
 None
 1.25A 1q23A-3zu4A:
undetectable
1q23B-3zu4A:
undetectable		 1q23A-3zu4A:
19.04
1q23B-3zu4A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 12 ALA A  62
GLY A  64
ILE A  28
ALA A  98
PHE A  94
 None
 1.19A 1ve3A-3zu4A:
6.0		 1ve3A-3zu4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 12 ALA A  62
GLY A  64
ILE A  28
ALA A  98
PHE A  94
 None
 1.14A 1ve3B-3zu4A:
6.1		 1ve3B-3zu4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 9 GLY A  71
SER A 107
LEU A  70
LEU A 129
HIS A  95
 None
 1.19A 1y7iA-3zu4A:
3.4		 1y7iA-3zu4A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 12 VAL A 295
LEU A 291
ASP A 350
GLN A 351
THR A 353
 None
 1.22A 3a35A-3zu4A:
undetectable		 3a35A-3zu4A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 12 VAL A 295
LEU A 291
ASP A 350
GLN A 351
THR A 353
 None
 1.17A 3a35B-3zu4A:
undetectable		 3a35B-3zu4A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 12 PHE A  73
PHE A  63
ALA A 105
SER A 107
SER A  91
 None
 1.43A 3apwA-3zu4A:
undetectable		 3apwA-3zu4A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 9 ASP A  29
GLY A  64
ILE A  37
ALA A  56
ILE A 306
 None
 1.07A 3ektB-3zu4A:
undetectable		 3ektB-3zu4A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 12 GLY A  54
GLY A  87
GLN A  27
VAL A  24
PHE A  73
 NA  A1402 (-3.5A)
None
None
None
None
 1.15A 3qowA-3zu4A:
4.0		 3qowA-3zu4A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 12 GLY A  40
VAL A 132
ARG A 255
GLY A 319
ASP A 265
 None
 1.08A 3sugA-3zu4A:
undetectable		 3sugA-3zu4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 12 GLY A  52
ALA A  56
VAL A 309
TYR A 313
LEU A 271
 NAI  A1400 (-3.5A)
None
None
None
NAI  A1400 (-4.7A)
 1.12A 4pd5A-3zu4A:
undetectable		 4pd5A-3zu4A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		4 / 8 GLN A 134
SER A 138
PHE A 223
SER A 269
 None
NA  A1402 ( 3.8A)
None
None
 0.96A 4wryA-3zu4A:
undetectable		 4wryA-3zu4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		4 / 8 GLN A 134
SER A 138
PHE A 223
SER A 269
 None
NA  A1402 ( 3.8A)
None
None
 0.95A 4wrzA-3zu4A:
undetectable		 4wrzA-3zu4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		4 / 8 GLN A 134
SER A 138
PHE A 223
SER A 269
 None
NA  A1402 ( 3.8A)
None
None
 1.01A 4ws1A-3zu4A:
undetectable		 4ws1A-3zu4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		3 / 3 VAL A 309
TYR A  53
ALA A  56
 None
NAI  A1400 ( 4.9A)
None
 0.54A 4ybnA-3zu4A:
undetectable		 4ybnA-3zu4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 12 SER A  86
SER A 280
GLU A  75
THR A  51
GLY A  52
 None
None
NAI  A1400 (-3.7A)
NAI  A1400 ( 3.6A)
NAI  A1400 (-3.5A)
 1.43A 4zjlA-3zu4A:
undetectable		 4zjlA-3zu4A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		4 / 6 GLU A 199
GLY A 198
GLY A 197
ASP A 246
 None
 0.90A 5a06D-3zu4A:
5.3		 5a06D-3zu4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 12 PHE A 223
VAL A  46
ILE A  47
ILE A 205
ILE A 254
 None
 1.02A 5hw8B-3zu4A:
undetectable
5hw8F-3zu4A:
undetectable
5hw8G-3zu4A:
undetectable		 5hw8B-3zu4A:
14.71
5hw8F-3zu4A:
14.71
5hw8G-3zu4A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 10 ILE A 254
LEU A 258
VAL A 132
ILE A  47
LEU A  45
 None
 1.00A 5ienB-3zu4A:
undetectable		 5ienB-3zu4A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 12 GLU A 116
LEU A 139
VAL A  72
GLY A 110
ILE A 117
 None
NAI  A1400 (-4.5A)
None
None
None
 1.06A 5vopA-3zu4A:
undetectable		 5vopA-3zu4A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 12 VAL A  24
GLY A  54
GLY A  52
GLN A 134
ALA A  57
 None
NA  A1402 (-3.5A)
NAI  A1400 (-3.5A)
None
None
 1.25A 5x7fA-3zu4A:
7.2		 5x7fA-3zu4A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 12 GLY A  48
ASP A 111
ALA A 112
LEU A 139
ALA A 140
 NAI  A1400 ( 3.4A)
NAI  A1400 (-3.9A)
NAI  A1400 (-3.3A)
NAI  A1400 (-4.5A)
ZU4  A1401 ( 3.3A)
 1.02A 6bq4A-3zu4A:
5.2		 6bq4A-3zu4A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		5 / 12 GLY A  48
ASP A 111
ALA A 112
LEU A 139
ALA A 140
 NAI  A1400 ( 3.4A)
NAI  A1400 (-3.9A)
NAI  A1400 (-3.3A)
NAI  A1400 (-4.5A)
ZU4  A1401 ( 3.3A)
 1.01A 6bq4B-3zu4A:
5.8		 6bq4B-3zu4A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		3 / 3 ARG A 267
GLY A 328
GLU A 327
 None
 0.56A 6fgdA-3zu4A:
undetectable		 6fgdA-3zu4A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		3 / 3 VAL A  44
ALA A  67
GLN A 134
 None
 0.63A 6gb9A-3zu4A:
2.3		 6gb9A-3zu4A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1
(Yersinia
pestis) 		4 / 5 GLY A  52
LEU A  55
SER A  86
GLN A 277
 NAI  A1400 (-3.5A)
None
None
NAI  A1400 (-4.7A)
 1.27A 6ji6A-3zu4A:
undetectable		 6ji6A-3zu4A:
19.08